Ruthenium-Promoted Acceptorless and Oxidant-Free Lactone Synthesis in Aqueous Medium

GenkiT oyooka andKen-ichi Fujita* [a] Ac atalytic system for the synthesis of dicarboxylic acids from aqueous solutions of diols accompanied by the evolution of hydrogen was developed. An iridium complex bearing af unctional bipyridonate ligand with N,N-dimethylamino substituents exhibitedahigh catalytic performance for this type of dehydrogenative reaction. For example, adipic acidw as synthesized from an aqueous solution of 1,6-hexanediol in 97 %y ield accompanied by the evolution of four equivalents of hydrogen by the presentc atalytic system. It shouldb en oted that the simultaneousp roduction of industrially important dicarboxylic acids andh ydrogen, which is useful as an energy carrier, was achieved. In addition, the selectived ehydrogenative oxidation of vicinal diols to give a-hydroxycarboxylic acids was also accomplished. Scheme1.Methods for the production of dicarboxylic acids.

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Lactonization of Diols Over Highly Efficient Metal‐Based Catalysts

Tan,

Min,

Wang

et al. 2024

ChemSusChem

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Lactones has gained increasing attention in recent years due to wide application in polymer and pharmaceutical industries. Traditional synthetic methods of lactones often involve harsh operating temperature, use of strong alkalis and toxic oxidants. Therefore, lactonization of diols under milder conditions have been viewed as the most promising route for future commercialization. A variety of metal catalysts (Ru, Pt, Ir, Au, Fe, Cu, Co, and Zn) have been developed for highly efficient oxidant‐, acceptor‐, base‐ and additive‐free lactonization processes. However, only a few initial attempts have been reported with no further details on catalytic mechanism being disclosed in literature. There demands a systematic study of the mechanistic details and the structure‐function relationship to guide the catalyst design. In this work, we critically reviewed and discussed the structure‐function relationship, the catalytic reaction mechanism, the catalyst stability, as well as the effect of oxidant and solvent for lactonization of diols. This work may provide additional insights for the development of other oxygen‐containing functional molecules for material science and technologies.

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Ruthenium-Promoted Acceptorless and Oxidant-Free Lactone Synthesis in Aqueous Medium

Cited by 7 publications

References 6 publications

Oxidation and Reduction

Oxidation and Reduction

Synthesis of Dicarboxylic Acids from Aqueous Solutions of Diols with Hydrogen Evolution Catalyzed by an Iridium Complex

Lactonization of Diols Over Highly Efficient Metal‐Based Catalysts

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