Ruthenium Tetraammines as a Model of Nitric Oxide Donor Compounds

Abstract

[a] Dedicated to our friend and colleague Luiz Manoel Aleixo in memoriam

PAMAM dendrimers functionalized with ruthenium nitrosyl as nitric oxide carriers

“…Analogous results were obtained for other ruthenium nitrosyl immobilized on PAMAM dendrimers [30] and in other matrices [17]. It is interesting to recall that these potentials are in the accessible range for biological reducing agents [7,57], which potentially enables the title compounds as candidates for therapy use.…”

Experimental Chemotherapy againstTrypanosoma cruziInfection Using Ruthenium Nitric Oxide Donors

“…In this context, the ruthenium species of the group trans- (44). Additionally, these compounds exhibit low cytotoxicity and good water solubility (up to 10 Ϫ2 M) and are stable for days under physiological hydrogen ion conditions (43).…”

Mechanisms of Nitric Oxide Reactions Mediated by Biologically Relevant Metal Centers

“…The effect of NO coordination on the ligands trans to the M-NO bond has also been addressed computationally for several {MNO} 6 and {MNO} 7 systems [57][58][59][60][61][62]. For the latter complexes the interaction between the axial d z 2 orbital of the metal and the half-filled π* orbital of the bent nitrosyl ligand leads to weakening of the bond to the ligand trans to the nitrosyl as suggested by the Traylor/Sharma hypothesis.…”