Rutin and quercetin enhance glucose uptake in L6 myotubes under oxidative stress induced by tertiary butyl hydrogen peroxide

Dhanya, R.; Arun, K. B.; Syama, H. P.; Nisha, P.; Sundaresan, A.; Kumar, T. R. Santhosh; Jayamurthy, P.

doi:10.1016/j.foodchem.2014.02.151

Cited by 68 publications

(41 citation statements)

References 36 publications

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“…In fact, the absence of a compensatory increase in endogenous antioxidant activity results in the activation of stress-sensitive signalling pathways (Dhanya et al 2014). In this context, the concentration of H 2 O 2 used in the current study was sufficient to induce cell death, resulting in a weak induction of endogenous antioxidants (SOD and HO-1) and a significant induction of oxidative stress and atrophy, as also reported by McClung et al (2009) in C2C12 myotubes.…”

Section: Discussionmentioning

confidence: 99%

A comparison of melatonin and α-lipoic acid in the induction of antioxidant defences in L6 rat skeletal muscle cells

Favero

Rodella

Nardo

et al. 2015

AGE

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Aging is characterized by a progressive deterioration in physiological functions and metabolic processes. The loss of cells during aging in vital tissues and organs is related to several factors including oxidative stress and inflammation. Skeletal muscle degeneration is common in elderly people; in fact, this tissue is particularly vulnerable to oxidative stress since it requires large amounts of oxygen, and thus, oxidative damage is abundant and accumulates with increasing age. Melatonin (N-acetyl-5-methoxytryptamine) is a highly efficient scavenger of reactive oxygen species and it also exhibits beneficial anti-inflammatory and anti-aging effects. This study investigated the susceptibility of rat L6 skeletal muscle cells to an induced oxidative stress following their exposure to hydrogen peroxide (50 μM) and evaluating the potential protective effects of pre-treatment with melatonin (10 nM) compared to the known beneficial effect of alpha-lipoic acid (300 μM). Hydrogen peroxide-induced obvious oxidative stress; it increased the expression of tumour necrosis factor-alpha and in turn promoted nuclear factor kappa-B and overrode the endogenous defence mechanisms. Conversely, pre-treatment of the hydrogen peroxide-exposed cells to melatonin or alpha-lipoic acid increased endogenous antioxidant enzymes, including superoxide dismutase-2 and heme oxygenase-1; moreover, they ameliorated significantly oxidative stress damage and partially reduced alterations in the muscle cells, which are typical of aging. In conclusion, melatonin was equally effective as alpha-lipoic acid; it exhibited marked antioxidant and anti-aging effects at the level of skeletal muscle in vitro even when it was given in a much lower dose than alpha-lipoic acid.

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Section: Discussionmentioning

confidence: 99%

A comparison of melatonin and α-lipoic acid in the induction of antioxidant defences in L6 rat skeletal muscle cells

Favero

Rodella

Nardo

et al. 2015

AGE

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“…The glucose uptake study revealed that crude extracts of cumin enhance the glucose uptake by the cells. Cinnamic acid, ferulic acid, ellagic acid and quercetin have been associated with increased glucose uptake activity (Lakshmi et al 2009;Prabhakar and Doble 2009;Poulose et al 2011;Dhanya et al 2014). The higher content of polyphenols like cinnamic acid, ferulic acid, ellagic acid, quercetin, etc.…”

Section: Glucose Uptake Assaymentioning

confidence: 99%

Nutraceutical properties of cumin residue generated from Ayurvedic industries using cell line models

et al. 2016

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Spent cumin (SC), generated from Ayurvedic industry, was evaluated for its nutraceutical potential in terms of antioxidant, antidiabetic and anticancer properties, and compared with that of the raw cumin (RC). SC and RC seeds were extracted with ethyl acetate (E) and methanol (M). SCM (methanol extract) were rich in p-coumaric acid, ferulic acid, ellagic acid and cinnamic acid (6.4445, 5.8286, 2.1519, 4.3085 mg/g dry extract). SCM reduced Fe 2? ion (89.68 lM AA/g dry weight), scavenged DPPH radical (IC 50 -238.6 lg/mL), better a-amylase inhibition (IC 50 -337.22 lg/mL) and glucose uptake activity in 30.7% of L6 cells. SCM inhibited viability, retarded migration area up to 41.02%, arrested cell cycle at S phase and induced apoptosis in 2.45% of HT29 colon cancer cells. The results indicated that dietary interventions using nutraceutical food formulation made out of SC can play a significant role in the prevention and management of degenerative diseases.

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“…43 In another study, Song et al demonstrated that CAPE prevent H 2 O 2 -induced oxidative stress in human middle ear epithelial cells due to decreasing intracellular ROS. 42 Dhanya et al found that quercetin prevents t-BHP induced oxidative stress in L6 myoblasts 44 , while Lee et al demonstrated that CAPE protects human liver (HepG2) cells against t-BHP induced oxidative stress through decreasing amount of intracellular ROS. 45 Mentioned above in literature showed that reduction intracellular ROS in different cell lines both by each extract components of propolis and total propolis extract were reported and similar results was found for EEP effect in this particular study.…”

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confidence: 99%

Antioxidant Properties and Protective Effect of Turkish Propolis on t-BHP-Induced Oxidative Stress in Foreskin Fibroblast Cells

Mısır¹,

Aliyazıcıoğlu²,

Demir³

et al. 2018

IJPER

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Objective: Propolis is an important bee product, rich in polyphenolic compounds. It has antitumoral, antioxidant, antimutagenic, and other useful activities. Biological activities of propolis are generally attributed to its substance of polyphenolic compounds. The aim of this study was to investigate the in vitro antioxidant properties and reduction amount of intracellular reactive oxygen species (ROS) in human normal foreskin fibroblast cells by Turkish propolis ethanolic extract (EEP). Method: Total phenolic and flavonoid contents, reducing power, radical scavenging capacity, and iron chelating activity of EEP were determined using spectrophotometric methods. Intracellular ROS levels were determined by spectrofluorometric analysis with CM-H 2 DCFDA. Results: Our results indicated that antioxidant activity was correlated with the higher total phenolic and flavonoid contents of EEP. The generated ROS levels were significantly decreased by EEP compared to only t-BHP group. Conclusion: Ethanolic propolis extract may be evaluated as a potency antioxidant resource and/or a novel natural agent in food and drug industries.

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Rutin and quercetin enhance glucose uptake in L6 myotubes under oxidative stress induced by tertiary butyl hydrogen peroxide

Cited by 68 publications

References 36 publications

A comparison of melatonin and α-lipoic acid in the induction of antioxidant defences in L6 rat skeletal muscle cells

A comparison of melatonin and α-lipoic acid in the induction of antioxidant defences in L6 rat skeletal muscle cells

Nutraceutical properties of cumin residue generated from Ayurvedic industries using cell line models

Antioxidant Properties and Protective Effect of Turkish Propolis on t-BHP-Induced Oxidative Stress in Foreskin Fibroblast Cells

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