Rutin attenuates neurobehavioral deficits, oxidative stress, neuro-inflammation and apoptosis in fluoride treated rats

Nkpaa, Kpobari W.; Onyeso, Godspower I.

doi:10.1016/j.neulet.2018.06.023

Cited by 48 publications

(22 citation statements)

References 29 publications

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“…The quercetin-rich A. cepa extract improves motor coordination and memory functions in aluminium chloride (AlCl 3 )-induced neurotoxicity in mice by ameliorating the tested oxidative stress biomarkers in serum including lipid peroxidation, glutathione levels, and catalase activity [89]. In addition, acetylcholinesterase (AChE) activity, a possible marker of low-grade systemic neuro-inflammation [120][121][122], is also significantly reduced in AlCl 3 exposed animals receiving onion extract [89]. Previously, the kinetics studies of quercetin suggested its competitive type of inhibition against AchE [123].…”

Section: Neuroprotective Effectsmentioning

confidence: 99%

Allium Flavonols: Health Benefits, Molecular Targets, and Bioavailability

2020

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Allium species are revered worldwide as vegetables, condiments, and spices as well as the therapeutic agents in traditional medicine. The bioactive compounds in alliums mainly include organosulfur compounds, polyphenols, dietary fibers, and saponins. Flavonoids, particularly flavonols from alliums, have been demonstrated to have the antioxidant, anticancer, hypolipidemic, anti-diabetic, cardioprotective, neuroprotective, and antimicrobial activities. However, flavonols are mostly characterized from onions and have not been comprehensively reviewed across different species. This article therefore focuses on flavonol profiles from different Allium species, their health effects, underlying molecular mechanisms, and bioavailability. Intriguingly, the functional health effects of flavonols were mainly ascribed to their antioxidant and anti-inflammatory activities involving a cascade of multiple signaling pathways. Although the Allium-derived flavonols offer tremendous potential in preventing chronic disease risks, in-depth studies are needed to translate their clinical application.

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Section: Neuroprotective Effectsmentioning

confidence: 99%

Allium Flavonols: Health Benefits, Molecular Targets, and Bioavailability

2020

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“…It has been reported that ROS are mediators of the mitochondria, DNA repair enzymes, and transcription factors, which contribute to neuronal apoptosis . They are involved in the release of cytotoxic substances during oxidative stress responses after ischemic stroke .…”

Section: Discussionmentioning

confidence: 99%

Protective effects of leonurine against ischemic stroke in mice by activating nuclear factor erythroid 2‐related factor 2 pathway

Xie

Zhang

et al. 2019

CNS Neurosci Ther

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Aims Leonurine has been shown to trigger antioxidant responses during ischemic stroke, and nuclear factor erythroid 2‐related factor 2 (Nrf‐2) imparts protective effects against oxidative injury. The present study has determined that leonurine prevents ischemic injury of brain tissues via Nrf‐2 pathway activation. Methods Male ICR mice and Nrf‐2−/− mice were subjected to permanent middle cerebral artery occlusion (pMCAO) and received leonurine treatment at 2 hours after pMCAO by intraperitoneal injection. Neurological deficit scores as well as infarct volume were assessed to determine the neuroprotective role of leonurine. Nrf‐2 was investigated using Western blotting and real‐time polymerase chain reaction (RT‐PCR) analysis to elucidate the neuroprotective mechanism of leonurine. Commercial kits were employed to determine reactive oxygen species (ROS), superoxide (SOD), catalase (CAT), glutathione peroxidase (GSH‐Px), malonaldehyde (MDA), and glutathione (GSH). Vascular endothelial growth factor (VEGF) was evaluated by Western blotting and RT‐PCR analysis, and VEGF was localized using immunofluorescence. Results The application of leonurine on ICR mice resulted in an improvement in neurological deficit scores and a reduction in infarct volume. Leonurine upregulated nuclear Nrf‐2 protein and increased total Nrf‐2 protein expression and mRNA levels. Leonurine regulated SOD, MDA, CAT, GSH, and GSH‐Px, and it significantly inhibited ROS production in ICR mice. Leonurine improved VEGF expression and increased VEGF expression in neurons, astrocytes, and endothelial cells. However, leonurine had no obvious beneficial effects on Nrf‐2−/− mice. Conclusions Leonurine exerted neuroprotective effects, promoted antioxidant responses, and upregulated VEGF expression by activating the Nrf‐2 pathway.

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“…The rats orally co-treated by gavage with rutin and sodium fluoride showed a reversal of the NaF-induced neurobehavioral deficits. Further, the co-treatment attenuated the NaF-induced inhibition of antioxidant enzymes and acetylcholine esterase activity and inhibited lipid peroxidation, neuro-inflammation, and apoptosis in the cerebrum and striatum of the rats, thus, rutin may be used as a neuroprotective agent against fluoride-induced neurotoxicity (Nkpaa and Onyeso, 2018).…”

Section: Neuroprotective Propertymentioning

confidence: 96%

A review on the chemistry and biological properties of Rutin, a promising nutraceutical agent

Prasad¹,

Prasad²

2019

Asian J Pharm Pharmacol

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Nature is an attractive source of new therapeutic agents and a variety of phytochemicals have proved to be very valuable in the prevention and treatment of various diseases. Many of the important drugs isolated from plants during the past 50 years have revolutionized modern medicinal practice (Dar et al., 2017). The use of herbal medicines and phytonutrients or nutraceuticals continues to expand rapidly across the world with many people now resorting to these products for the treatment of various health challenges in different national healthcare settings (WHO, 2004). It is estimated that up to 80% of the world's population living in the developing countries rely on herbal medicinal products as a primary source of healthcare and traditional medical practice as an integral part of the culture in their communities (Ekor, 2013). The medicinal compounds derived from various plants could be divided into three major biochemical classes: alkaloids (vinblastine, vincristine, pilocarpine, berberine, caffeine, piperine etc.), flavonoids (quercetin, kaempferol, chrysin, naringenin, genistein, rutin etc.) and terpenoids (artemisinin, taxol, digitoxin, azadarachtin, camphor, limonene etc.) (Takshak, 2018). These compounds have also gained importance in the area of nutraceuticals, which have positive health effects and may prove to be advantageous in the treatment of diseases like cancer, cardiovascular diseases and diabetes (Crozier et

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Rutin attenuates neurobehavioral deficits, oxidative stress, neuro-inflammation and apoptosis in fluoride treated rats

Cited by 48 publications

References 29 publications

Allium Flavonols: Health Benefits, Molecular Targets, and Bioavailability

Allium Flavonols: Health Benefits, Molecular Targets, and Bioavailability

Protective effects of leonurine against ischemic stroke in mice by activating nuclear factor erythroid 2‐related factor 2 pathway

A review on the chemistry and biological properties of Rutin, a promising nutraceutical agent

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