Rutin potentially attenuates fluoride-induced oxidative stress-mediated cardiotoxicity, blood toxicity and dyslipidemia in rats

Abstract

This study was undertaken to evaluate cardio protective effect of rutin against sodium fluoride (NaF)-induced oxidative stress-mediated cardiotoxicity and blood toxicity. Cardiac injury was induced by daily administration of NaF 600 ppm in distilled water for four weeks. The animals exposed to NaF exhibited a significant increase in levels of cardiac serum markers, lipid peroxidative markers, serum total cholesterol, LDL, triglycerides and decrease in HDL levels. Decrease in hematological parameters, namely hemoglobin, red blood cells, mean corpuscular volume, mean corpuscular hemoglobin (MCH), MCH count and increase in white blood cells and erythrocyte sedimentation levels were also observed. Marked histopathological lesions and increased DNA fragmentation in cardiac tissues were observed. Activity of antioxidants-catalase, superoxide dismutase and reduced glutathione contents were decreased (p < 0.01), whereas lipid peroxidation product (malondialdehyde) was increased. A significant decrease in body and heart weight was also observed. Treatment with rutin effectively ameliorated the alterations in the studied parameters of rat through its antioxidant nature. There was also significant improvement in hematological parameters. Thus, results of this study clearly demonstrated that treatment with rutin against NaF intoxication has a significant role in protecting F-induced cardiotoxicity, blood toxicity and dyslipidemia in rats.

Antioxidant, Antimicrobial and Cytotoxic Properties as Well as the Phenolic Content of the Extract from Hancornia speciosa Gomes

“…The inhibition of lipid peroxidation was also determined by the quantification of the levels of MDA, which is a marker of oxidative damage to the lipids found in the erythrocyte membranes [49]. Umarani et al [50] reported that the flavonoid rutin, also present in the EEHS, promoted the inhibition of lipid peroxidation in the heart tissue of rats subjected to oxidative stress. Henneberg et al [51] reported the ability of rutin to sequester reactive oxygen species in human erythrocytes subjected to oxidative damage.…”

Effects of Polyphenols on Oxidative Stress-Mediated Injury in Cardiomyocytes

“…Only rutin possessed the ability to attenuate cardiac I/R-associated hemodynamic alterations [159]. In addition, rutin increased anti-oxidant molecules and reduced cells necrosis and apoptosis and overall cardiac dysfunction in rats exposed to sodium fluoride-induced oxidative stress [160]. …”

Barium chloride dose‐dependently induced heart and lung injury in Wistar rats

“…They are equipped with an effective and complex antioxidant system against oxidative stress, including protective enzymes and biological antioxidants such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase, reduced glutathione (GSH), and metallothionein (MT) . However, these endogenous antioxidants system can become overwhelmed as a result of over generation of reactive oxygen species (ROS), thereby triggering oxidative cells damage, inflammation, and endothelia dysfunctions which make these organs susceptible to injury . Heart has been reported to be the main target of mitochondrial injury owing to the inhibition of antioxidant defenses and activation of pro‐inflammatory cytokines .…”

“…11 Heart has been reported to be the main target of mitochondrial injury owing to the inhibition of antioxidant defenses and activation of pro-inflammatory cytokines. 11 Hence cardiac cells are easily susceptible to reactive oxygen species, which is the determinant of oxidative tissue damage.…”