S.06.02 Genetics of early onset in OCD

Walitza, Susanne; Renner, John A.; Lange, Karla; Lesch, K.P.; Warnke, A.

doi:10.1016/s0924-977x(08)70142-1

Cited by 1 publication

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“…Possible investigations of interaction between genes and environment in OCD include the role of polymorphisms in the development of OCD after traumatic events, or streptococcus infection, or even the influence of polymorphisms in the development of personality traits risk for OCD 157 . The definition of endophenotypes by neuroimaging studies, neurophysiology and neuropsychology are essential in guiding genetic studies 157 .…”

Section: Discussionmentioning

confidence: 99%

Estudos de associação genética no transtorno obsessivo-compulsivo

Sampaio¹,

Lins²,

Daltro-Oliveira³

et al. 2013

Rev. psiquiatr. clín.

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Background: Obsessive-compulsive disorder (OCD) segregates in families. It follows a complex model of genetic transmission, which involves the influence of several small effect genes interacting with the environment. Methods: A systematic review of genetic association studies in OCD was performed. Articles published until 2012 were searched in the databases PubMed, Embase and ScieLO using the terms of MeSH and its associates or synonyms for "obsessivecompulsive disorder", "gene" and "genetic association studies". Results: We selected 105 papers and described their main results grouped as genes related to: serotonin, dopamine, glutamate, GABA, white matter, immune system, hormones and other genes. Discussion: There is high variability between findings of association studies among the several candidate genes studied in OCD. Glutamate-related genes are promising candidates for OCD, but there is no conclusive association between any of the candidate genes studied and OCD. Association studies with large sample size, evaluation of more homogeneous subgroups of phenotype and meta-analyses are still needed.

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Section: Discussionmentioning

confidence: 99%