S-(1-2-dicarboxyethyl)cysteine in urine and kidney

Kuwaki, Takahiro; Mizuhara, Shunzi

doi:10.1016/0304-4165(66)90449-1

Cited by 26 publications

(7 citation statements)

References 5 publications

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“…S-(I ,2-Dicarboxyethyl)-~-cysteine has been known to be present in several animal tissues [14, 161, normal human urine [16], and asparagus shoots [17]. The administration of maleic acid into rats has been reported to increase urinary excretion of this compound and the binding of maleic acid to tissue proteins [18].…”

Section: Discussionmentioning

confidence: 99%

Occurrence of S‐(1,2‐dicarboxyethyl)‐cysteine at position 77 in mutant human lysozyme secreted by Saccharomyces cerevisiae

Kikuchi

Taniyama

Kanaya

et al. 1990

European Journal of Biochemistry

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A mutant human lysozyme PI1', in which Val110 was replaced with Pro, was secreted by Succharomyces cerevisiae; modification of the cysteine residue at position 77 was found in a purified mutant protein (Pl'O-B) upon primary structure analysis. A peptide fragment containing 15 amino acid residues from Thr70 to Leu84 was obtained by proteolytic digestion of the protein and subsequently isolated by reverse-phase HPLC. This fragment was analyzed by high-resolution fast-atom-bombardment (FAB) mass spectrometry, which showed that 1,2-dicarboxyethyl group was attached to the thiol group of Cys77. This modification was confirmed by comparing it with a sample of chemically synthesized S-(l,2-dicarboxyethyl)-~-cysteine.It was found that the modification caused a disruption of the disulfide bond Cys77-Cys95 in the mutant molecule. These observations, plus structural considerations, suggest that Cys77 and Cys95 either remain uncrosslinked or the disulfide bond Cys77 -Cys95, once formed, is opened during the final step in the folding of human lysozyme in vivo.

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Section: Discussionmentioning

confidence: 99%

Occurrence of S‐(1,2‐dicarboxyethyl)‐cysteine at position 77 in mutant human lysozyme secreted by Saccharomyces cerevisiae

Kikuchi

Taniyama

Kanaya

et al. 1990

European Journal of Biochemistry

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“…S-(l,2-dicarboxyethyl)-L-cysteine was synHfled in ,he urine and kidney of guinea pig (2), in ox ^^^^*^^™^. brain and spinal cord (3) and in ox liver and kidney (4).…”

Section: Introductionmentioning

confidence: 99%

S-(1,2-Dicarboxyethyl)glutathione and Glutathione in Lens and Liver of Naphthalene-Treated Rabbits

Takemura¹,

Ueno²,

Kodama³

1996

CCLM

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Summary:The determination of S-(l,2-dicarboxyethyl)glutathione and reduced glutathione (GSH) in the rabbit lens and liver was developed using an isotachophoretic analyser.The recovery of S-(l,2-dicarboxyethyl)GSH from the rabbit liver after ion-exchange treatment was 96.8 ± 11.3% (n = 3). The contents of S-(l,2-dicarboxyethyl)GSH in the rabbit lens and liver were 219.9 ± 29.1 (n = 5) and 44.0 ± 13.5 (n = 8) nmol/g, respectively.The contents of S-(l,2-dicarboxyethyl)GSH in the lens and GSH in the lens and liver of naphthalene-treated rabbits was also determined by this method 24 hours after naphthalene administration, at which time the axial opacity "spichen" was observed at the equatorial region of the lens. The content of S-(l,2-dicarboxyethyl)GSH in the lens decreased in proportion to the content of GSH.During the further development of true lens opacity after naphthalene administration, the S-(l,2-dicarboxyethyl)GSH content further compared with that in the spichen stage, but the S-(l,2-dicarboxyethyl)GSH content of the lens that did not develop true opacity after naphthalene administration returned to the normal level. The change of S-(l,2-dicarboxyethyl)GSH content of the lens in the spichen and true opacity stages coincided with that of GSH content.On the other hand, the content of GSH of the liver decreased markedly until 24 hours after naphthalene administration, then returned to normal, irrespective of whether true opacity did or did not subsequently develop.

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“…1). These addition products have been found in the lenses of different vertebrates [13,14], in human urine [15] and in the liver and kidney of the ox [16].…”

Section: Introductionmentioning

confidence: 99%

Stereochemical Considerations on Concomitant Allergic Contact Dermatitis to Ester of the <i>cis-trans</i> Isomeric Compounds Maleic Acid and Fumaric Acid

Hansson

Thörneby‐Andersson²

2003

Skin Pharmacol Physiol

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Allergic contact dermatitis from esters of fumaric acid or esters of maleic acid is rare. The case of a chemist with allergic reactions to esters both of fumaric acid and of maleic acid is presented. Extremely high sensitivity of the patient to diethyl fumarate was noted. The formation of identical complete antigens from esters of these two cis-trans isomeric acids may be an explanation of the patient’s double allergy. This is discussed from a stereochemical point of view. These stereochemical considerations point to a general mechanism where cis-trans isomeric α,β-unsaturated carbonyl compounds are converted into the same complete antigen.

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S-(1-2-dicarboxyethyl)cysteine in urine and kidney

Cited by 26 publications

References 5 publications

Occurrence of S‐(1,2‐dicarboxyethyl)‐cysteine at position 77 in mutant human lysozyme secreted by Saccharomyces cerevisiae

Occurrence of S‐(1,2‐dicarboxyethyl)‐cysteine at position 77 in mutant human lysozyme secreted by Saccharomyces cerevisiae

S-(1,2-Dicarboxyethyl)glutathione and Glutathione in Lens and Liver of Naphthalene-Treated Rabbits

Stereochemical Considerations on Concomitant Allergic Contact Dermatitis to Ester of the <i>cis-trans</i> Isomeric Compounds Maleic Acid and Fumaric Acid

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