S‐100 protein‐immunoreactive cells in the bovine ovary

Kamiya, Shinji; Tsukushi, Masumi; Yamano, Shuji; Daigo, M.

doi:10.1002/ar.1092230406

Cited by 7 publications

(8 citation statements)

References 11 publications

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“…Small S100-positive blood vessels penetrate the dispersed granulosa cells. Immunoreactivity for S100 protein was also observed in the ovarian rete as well as in ovarian cysts [Kamiya et al, 1989]. Haimoto et al [1987] describe S100 expression in the oocytes of primordial follicles and in their follicle epithelium.…”

Section: Discussionmentioning

confidence: 99%

The Role of Ovarian Surface Epithelium in Folliculogenesis during Fetal Development of the Bovine Ovary: A Histological and Immunohistochemical Study

Kenngott

Vermehren

Ebach

et al. 2013

Sex Dev

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Although many aspects of ovarian differentiation have been established, comparatively little is known about prenatal follicle formation and differentiation of bovine ovaries. The objective of this investigation was to study the role of the surface epithelium during the development of germ cell nests, germ cell cords and follicle formation in the fetal bovine ovary. Associated important proliferation and apoptotic features were further investigated. Additionally, the expression pattern of the S100 protein was detected. A strong increase of mitotic figures was detected in the surface epithelium, germ cell nests and germ cell cords of ovaries with a crown-rump length (CRL) of 13.0-58.0 cm. Oocytes were positively stained with S100 in bovine ovaries from fetuses with a CRL of 21.0 cm. The staining intensity enhanced parallel to increasing oocyte and follicle sizes during the ovary development. In later stages, a strong staining for S100 was observed in healthy oocytes in contradistinction to atretic oocytes where no expression of the S100 protein could be found. In conclusion, increasing mitosis index of surface epithelium cells, as well as oogonia directly beneath the surface epithelium, in combination with open surface connection during stages from a CRL of 11.0-94.0 cm of bovine fetal ovaries could play an important role in the period of time of ongoing folliculogenesis and derivation of granulosa cells. Additionally, S100-positive oocytes in primordial and later follicle stages joined by a high rate of Ki67-positive index in surrounding granulosa cells indicate that in the oocytes the S100 protein can perhaps be a useful marker for intact oocytes in bovine ovaries.

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Section: Discussionmentioning

confidence: 99%

The Role of Ovarian Surface Epithelium in Folliculogenesis during Fetal Development of the Bovine Ovary: A Histological and Immunohistochemical Study

Kenngott

Vermehren

Ebach

et al. 2013

Sex Dev

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“…Initially, S-100 proteins were considered to be specific for nervous tissue [Bock, 1978]. However, numerous immunohistochemical and biochemical studies have revealed that S-100 proteins are also present in other tissues than the nervous system, particularly in the ovary [Kamiya et al, 1989], bovine testis [Ahmed and Sinowatz, 2005], and bovine ovary [AbdElhafeez et al, 2011]. S-100 proteins belong to a family of Ca 2+ -binding proteins [Isobe et al, 1982] and display different cell functions.…”

Section: Discussionmentioning

confidence: 99%

New Description of Telocyte Sheaths in the Bovine Uterine Tube: An Immunohistochemical and Scanning Microscopic Study

Abd‐Elhafeez

Soliman

2016

Cells Tissues Organs

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Telocytes are a special type of interstitial cells characterized by distinctive cellular extensions with alternating thin segments (podomers) and dilations (podoms). Telocytes establish contact with various cells and structures, but their role in the regulation of the function of many cell types is still obscure. The aim of the current study was to investigate the morphology, histochemistry, and immunohistochemistry of telocytes, and their distribution, organization, and morphometric measurements in different layers of the adult bovine uterine tube. Telocytes showed positive immunostaining for CD117, S-100 protein, vimentin, desmin, α-smooth muscle actin, tubulin, laminin, estrogen receptor-α, and progesterone receptor. They were organized in different types of sheaths: subepithelial, inner/outer perimuscular, and intramuscular sheaths. Telocytes were scattered in the lamina propria, in the muscular layer, and the serosa. According to their size, they were grouped into different types of telocytes: small, large, and giant telocytes. Small telocytes were the most common type and located in all layers; large telocytes were observed in the epithelium, lamina propria, and inner/outer perimuscular and intramuscular sheaths, and giant telocytes were found in the external layer of the outer perimuscular sheath. Telocytes were connected by thin and thick telopodes (fenestrated membranes). Fenestrated membranes enabled connections between telocytes along the entire muscular wall of the uterine tube. Telocytes established an extensive biological network of different types of cells and structures, including epithelial, muscular, and mast cells, blood vessels, glomus, and nerve fibers. We hypothesize that telocytes help to organize the functional coordination between different types of cells in the uterine tube.

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“…1986: Iwanaga et al, 1987: Sugimura ct al.. 1987Kamiya et al. 1989], Despite many reports of S-100 pro tein in the intra-and extraneural tissues, little is known about the function of S-100 [Zimmer and Van Eldik, 1987], The present study is the first to demonstrate the locali zation of S-100 protein in the bovine oviduct.…”

Section: Discussionmentioning

confidence: 83%

“…Recently, immunohistochemical and immunochemical studies have revealed that S-100 protein is not specific for nervous tissues but is widely dis tributed among animal and human cells such as chondro cytes, adipocytes, macrophages, follicular dendritic cells andoocytes [Takahashietal.. 1984;V anstapeletal.. 1986: Iwanaga et al. 1987: Sugimura et al, 1987Uchida and Endo, 1988;Kamiya et al. 1989].…”

Section: Introductionmentioning

confidence: 99%

Immunohistochemical Demonstration of S-100 Protein in Epithelial Cells of Bovine Oviduct

Kamiya

Tajika²,

Daigo³

1989

Cells Tissues Organs

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The present study deals with an immunohistochemical localization of S-100 protein in the bovine oviduct. The epithelium of the infundibulum, ampulla and isthmus showed a positive staining for S-100 protein. The immunoreactivity for S-100 was observed both in the ciliated and nonciliated (secretory) cells of the oviductal epithelium at any stages of the estrous cycle. The immunoreactivity was also found in nervous elements and endothelial cells of blood vessels. No cell outside these cells showed any immunoreactivity for S-100. Although the functional significance of S-100 protein in the oviductal epithelium remains to be elucidated, the present results introduce new perspectives into the investigation of function and localization of S-100 protein.

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S‐100 protein‐immunoreactive cells in the bovine ovary

Cited by 7 publications

References 11 publications

The Role of Ovarian Surface Epithelium in Folliculogenesis during Fetal Development of the Bovine Ovary: A Histological and Immunohistochemical Study

The Role of Ovarian Surface Epithelium in Folliculogenesis during Fetal Development of the Bovine Ovary: A Histological and Immunohistochemical Study

New Description of Telocyte Sheaths in the Bovine Uterine Tube: An Immunohistochemical and Scanning Microscopic Study

Immunohistochemical Demonstration of S-100 Protein in Epithelial Cells of Bovine Oviduct

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