(S)-2-Hydroxyprophyl-β-cyclodextrin, a new chiral stationary phase for reversed-phase liquid chromatography

Chiral stationary phases in HPLC for the stereoselective determination of methadone

“…Hence, a great number of compounds which are unresolved or partially resolved on native ␤-cyclodextrin can be separated on the ␤-RSP. 32,33 Capillary electrophoresis carried out in our laboratory with several cyclodextrins (native and derivatized) confirmed the ability of this selector to resolve Mtd enantiomers. 34 As indicated in Table 3, efficiency and resolution decrease rapidly as a function of the flow rate (in the range 0.4-1 ml/min).…”

“…30 Furthermore, secondary interactions with the hydroxypropyl group can drastically enhance chiral recognition versus the native cyclodextrin. 31,32 Finally, hydroxypropyl groups are flexible, allowing better hydrogen bonding with analytes. Hence, a great number of compounds which are unresolved or partially resolved on native ␤-cyclodextrin can be separated on the ␤-RSP.…”

“…With cyclodextrin-based stationary phases, the influence of organic modifiers in the mobile phase, such as acetonitrile (ACN), on chiral recognition is well described. 32,35 Retention and enantioselectivity can be influenced by the nature and percentage of the organic modifier used, as observed with a hydrophobic stationary phase. 17 Both retention factors (kЈ R-Mtd and kЈ S-Mtd) decreased by adding acetonitrile in the mobile phase, while efficiency increased.…”

Thin-layer chromatographic enantioseparation of ofloxacin and zopiclone using hydroxy-propyl-beta-cyclodextrin as chiral selector and thermodynamic studies of complexation

“…In HP-β-CD, some hydroxyl groups are substituted with hydroxypropyl functional groups. This modification allows for a more stereospecific and stronger interaction between the hydroxyl groups and hydrogen-bonding moiety present in the drug structure [27]. Cyclodextrins are well suited to chromatography since the inclusion process is stereoselective and reversible.…”

Enantiomeric Separation by Capillary Electrochromatography on a Sulfated Poly β-Cyclodextrin Modified Silica-based Monolith

“…Besides the native cyclodextrin, functionalized cyclodextrins, such as hydroxypropyl-β-CD, 11,16 naphthylethylcarbamoylated-β-CD, 17 perphenylcarbamoylated β-CD, 9 sulfated CDs 18 etc., were also be used as chiral selectors to expand the range of compounds that are enantioresolvable. Among functionalized CDs, sulfated CDs are recognized as being the best effective selectors, especially when they were used in CE as chiral additives.…”