Enantiomeric Separation by Capillary Electrochromatography on a Sulfated Poly β-Cyclodextrin Modified Silica-based Monolith

Yuan, Rongfang; Wang, Yan; Ding, Guoyu

doi:10.2116/analsci.26.943

Cited by 25 publications

(19 citation statements)

References 33 publications

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“…Yuan et al. used an allyl‐β‐CD MCSP for the enantiomeric resolution of ibuprofen in CEC within 20 min run time. Ibuprofen racemate was resolved on β‐CD CSP in CE by Lv et al.…”

Section: Applicationsmentioning

confidence: 99%

Advances in enantiomeric resolution on monolithic chiral stationary phases in liquid chromatography and electrochromatography

2014

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During the last decade, chiral monolithic stationary phases have been prepared and used for rapid enantioseparations in CEC and HPLC. Various chiral selectors are used to prepare these CSPs. The preparation, properties, and applications of these CSPs are discussed in this paper. Attempts have been made to describe optimization strategies and the chiral recognition mechanisms. A comparison of chiral separations in CEC and HPLC is described. Efforts have also been made to predict the future perspectives and challenges of chiral monolithic stationary phases. The most effective chiral selectors include polysaccharides, cyclodextrins, and macrocyclic glycopeptide antibiotics. These chiral phases produced acceptable analytical enantiomeric separation of a variety of racemates. However, the development of these CSPs for preparative-scale separations is needed.

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“…Yuan et al. used an allyl‐β‐CD MCSP for the enantiomeric resolution of ibuprofen in CEC within 20 min run time. Ibuprofen racemate was resolved on β‐CD CSP in CE by Lv et al.…”

Section: Applicationsmentioning

confidence: 99%

Advances in enantiomeric resolution on monolithic chiral stationary phases in liquid chromatography and electrochromatography

2014

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“…Hybrid silica/polymer and zirconia monoliths have also been recently introduced. To date, different approaches have been utilized to introduce enantioseparation abilities within capillary MSPs . These may include postchemical modifications, physical adsorption, and encapsulation strategies …”

Section: Cd‐based Chiral Msps: Preparation and Applicationsmentioning

confidence: 99%

“…Yuan et al reported a novel silica‐based monolithic column (75 µm i.d.) for chiral CEC separations . First, the authors prepared the monolithic column through a sol‐gel methodology followed by modification through radical polymerization with 2‐hydroxy‐3‐allyloxy‐propyl‐ β ‐CD and 3‐(methacryloxy)‐propyltriethoxysilane ( γ ‐MAPA).…”

Section: Cd‐based Chiral Msps: Preparation and Applicationsmentioning

confidence: 99%

Cyclodextrin‐Functionalized Monolithic Capillary Columns: Preparation and Chiral Applications

2015

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“…A silica-based monolith was modified with sulfated polyb-cyclodextrin through a radical polymerization reaction between allyl-b-cyclodextrin and g-3-(methacryloxy)propyltriethoxysilane (MAPS)-activated silica monolith [62]. The CDs on the monolith were then sulfated through a chlorogenic acid/pyridine mixture, which introduced sulfonic acid groups onto this selector.…”

Section: Cyclodextrin-based Selectorsmentioning

confidence: 99%

Enantioselective capillary electrochromatography: Recent developments and new trends

Mangelings

Heyden

2011

Electrophoresis

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Since its development in the early 1970s, CEC has been studied quite extensively, but unfortunately its use is still mostly located at an academic level. Reasons for this are the limited availability of commercially available stationary phases (SPs) and columns, along with some practical limitations, such as column fragility, lack of column robustness and reproducibility. Nevertheless, CEC maintains a place among the separation techniques, probably because of its unique feature to combine two separation principles. Also in the field of chiral separations, CEC is often used as a separation technique and already showed its potential for this kind of analyses. This overview will focus on the recent applications, i.e. between 2006 and 2010, in enantioselective analysis by means of CEC. For the selected applications, the used SPs (chiral selectors) and their potential for future method development or screening purposes will be evaluated and critically discussed.

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Enantiomeric Separation by Capillary Electrochromatography on a Sulfated Poly β-Cyclodextrin Modified Silica-based Monolith

Cited by 25 publications

References 33 publications

Advances in enantiomeric resolution on monolithic chiral stationary phases in liquid chromatography and electrochromatography

Advances in enantiomeric resolution on monolithic chiral stationary phases in liquid chromatography and electrochromatography

Cyclodextrin‐Functionalized Monolithic Capillary Columns: Preparation and Chiral Applications

Enantioselective capillary electrochromatography: Recent developments and new trends

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