S-Phase Accumulation of Candida albicans by Anticandidal Effect of Amentoflavone Isolated from Selaginella tamariscina

Jung, Hyun Jun; Park, Keunnam; Lee, In Seon; Kim, Hyun Soo; Yeo, Soo Hwan; Woo, Eun Rhan; Lee, Dong Gun

doi:10.1248/bpb.30.1969

Cited by 39 publications

(24 citation statements)

References 30 publications

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“…In Candida albicans , it could stimulate the intracellular trehalose accumulation and disrupt the dimorphic transition, which meant a stress response to the component [ 182 ]. Further research on its antifungal mechanism of Candida albicans suggested that this active phytochemical arrested cell cycles during the S-phase and inhibited cell proliferation and division [ 183 ]. The anti-candida activity was proved to be related to apoptotic cell death, which may be associated with the mitochondrial dysfunction.…”

Section: Pharmacologymentioning

confidence: 99%

A Review on the Phytochemistry, Pharmacology, and Pharmacokinetics of Amentoflavone, a Naturally-Occurring Biflavonoid

et al. 2017

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Amentoflavone (C30H18O10) is a well-known biflavonoid occurring in many natural plants. This polyphenolic compound has been discovered to have some important bioactivities, including anti-inflammation, anti-oxidation, anti-diabetes, and anti-senescence effects on many important reactions in the cardiovascular and central nervous system, etc. Over 120 plants have been found to contain this bioactive component, such as Selaginellaceae, Cupressaceae, Euphorbiaceae, Podocarpaceae, and Calophyllaceae plant families. This review paper aims to profile amentoflavone on its plant sources, natural derivatives, pharmacology, and pharmacokinetics, and to highlight some existing issues and perspectives in the future.

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Section: Pharmacologymentioning

confidence: 99%

A Review on the Phytochemistry, Pharmacology, and Pharmacokinetics of Amentoflavone, a Naturally-Occurring Biflavonoid

et al. 2017

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“…Numerous flavonoids are found in the crude extracts of Selaginella tamariscina that exhibit various pharmacological effects. Amentoflavone markedly arrested cell cycles and induced apoptosis of human breast and cervical cancer cells [21,27,28]. In addition, sumaflavone exerted anti-inflammatory effects by blocking iNOS expression through AP-1 inhibition [29].…”

Section: Discussionmentioning

confidence: 99%

Selaginella tamariscina Attenuates Metastasis via Akt Pathways in Oral Cancer Cells

et al. 2013

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BackgroundCrude extracts of Selaginella tamariscina , an oriental medicinal herb, have been evidenced to treat several human diseases. This study investigated the mechanisms by which Selaginella tamariscina inhibits the invasiveness of human oral squamous-cell carcinoma (OSCC) HSC-3 cells.Methodology/Principal FindingsHerein, we demonstrate that Selaginella tamariscina attenuated HSC-3 cell migration and invasion in a dose-dependent manner. The anti-metastatic activities of Selaginella tamariscina occurred at least partially because of the down-regulation of matrix metalloproteinases (MMP)-2 and MMP-9 gelatinase activity and the down-regulation of protein expression. The expression and function of both MMP-2 and MMP-9 were regulated by Selaginella tamariscina at a transcriptional level, as shown by quantitative real-time PCR and reporter assays. Chromatin immunoprecipitation (ChIP) data further indicated that binding of the cAMP response element-binding (CREB) protein and activating protein-1 (AP-1) to the MMP-2 promoter diminished at the highest dosage level of Selaginella tamariscina . The DNA-binding activity of specificity protein 1 (SP-1) to the MMP-9 promoter was also suppressed at the same concentration. Selaginella tamariscina did not affect the mitogen-activated protein kinase signaling pathway, but did inhibit the effects of gelatinase by reducing the activation of serine–threonine kinase Akt.ConclusionsThese results demonstrate that Selaginella tamariscina may be a potent adjuvant therapeutic agent in the prevention of oral cancer.

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“…Currently, many biflavonoids exhibit bioactive functions, and the mechanisms of such effects have been explored. For example, the amentoflavone derived from Selaginella tamariscina or Torreya nucifera has been shown to not only have potent anti-candidal or anti-SARS-coV activities [ 2 , 3 ], but also exhibits anti-neovascularization by interfering in the interaction of VEGF and VEGFR-1 [ 4 , 5 ]. In addition, 7,7″-dimethoxyagastisflavone (DMGF, the structure was shown as Figure 1A ) has been found to have anti-HSV-1 and -HSV-2 activity [ 6 ], and it can cause the cell death via apoptosis or autophagy [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

The inhibitory effect of 7,7″-dimethoxyagastisflavone on the metastasis of melanoma cells via the suppression of F-actin polymerization

Lin

et al. 2016

Oncotarget

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7,7″-Dimethoxyagastisflavone (DMGF), a biflavonoid isolated from Taxus × media cv. Hicksii, induces apoptotic and autophagic cell death. However, whether DMGF suppresses tumor metastasis is unclear. The aim of this study was to investigate the anti-metastatic activities of DMGF on the metastatic processes of melanoma cells in vivo and in vitro. A transwell assay showed that DMGF could effectively attenuate the motility of B16F10 cells, and the results of real-time PCR revealed that DMGF also suppressed the expressions of matrix metalloproteinase-2 (MMP-2). Moreover, DMGF did not influence tube formation but inhibited the migration of endothelial cells. Furthermore, animal models were used to monitor the effects of DMGF on tumor metastasis, and all models showed that DMGF significantly suppressed the metastatic behaviors of B16F10 cells, including intravasation, colonization, and invasion of the lymphatic duct. In addition, DMGF could also reduce the densities of the blood vessels in the tumor area in vivo. Further investigation of the molecular mechanisms of anti-metastatic activity revealed that DMGF can down-regulate the levels of key modulators of the Cdc42/Rac1 pathway to interfere in F-actin polymerization and suppress the formation of lamellipodia by reducing the phosphorylation of CREB. These data suggested that DMGF presents anti-metastatic activities in B16F10 melanoma cells. Here, we demonstrated that DMGF can inhibit the metastasis of highly invasive melanoma cancer cells through the down-regulation of F-actin polymerization. Considering these findings, DMGF may be further developed to serve as a chemoprevention drug for patients with metastatic melanoma.

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S-Phase Accumulation of Candida albicans by Anticandidal Effect of Amentoflavone Isolated from Selaginella tamariscina

Cited by 39 publications

References 30 publications

A Review on the Phytochemistry, Pharmacology, and Pharmacokinetics of Amentoflavone, a Naturally-Occurring Biflavonoid

A Review on the Phytochemistry, Pharmacology, and Pharmacokinetics of Amentoflavone, a Naturally-Occurring Biflavonoid

Selaginella tamariscina Attenuates Metastasis via Akt Pathways in Oral Cancer Cells

The inhibitory effect of 7,7″-dimethoxyagastisflavone on the metastasis of melanoma cells via the suppression of F-actin polymerization

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