S0798 Long-Term Outcomes of the Excluded Rectum in Crohn’s Disease – Results From the CAPER (Consortium to Assess Prognosis of the Excluded Rectum) Study

Kassim, Gassan; Debebe, Anketse; Cholapranee, Aurada; Sultan, Keith; Colombel, Jean–Frédéric; Sachar, David B.

doi:10.14309/01.ajg.0000705240.29218.7e

Cited by 1 publication

(14 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After the reviewing process, a total of 37 publications met the inclusion criteria 11,18, : thirty-three full-text (89.2%) 11,18,23,51,54,56 and four abstracts (10.8%). 52,53,55,57 Figure 1 illustrates the selection process.…”

Section: Resultsmentioning

confidence: 99%

“…All studies were single-center experiences, published between 1982 and 2021. The study design was as follows: two randomized studies (5.4%), 30,46 four prospective studies (10.8%), 33,34,38,40 14 retrospective studies (37.9%), 18,24,25,36,39,42,44,50,[52][53][54][55][56][57] and 17 case reports/series (45.9%). 23,26,29,31,32,35,37,41,43,45,47,49,51,56 Two papers were written in French 34,35 and one in German, 28 all remaining papers were written in English.…”

Section: Resultsmentioning

confidence: 99%

“…Table 1 presents all the included studies. According to the NOS score, 12 studies were of high-quality (32.4%), 11,18,33,36,39,40,44,50,53,55,57 one paper was of low quality, 56 and the remaining studies were moderate-quality studies (59.5%) (Table S1, supplementary material). A Jadad score of 4 was assigned to the randomized studies.…”

Section: Resultsmentioning

confidence: 99%

“…Symptoms of DP were assessed in 17 studies 11,18,25,26,28,31,36,40,41,44,47,49,55,56 : only a minority of the IBD patients (30%-40%) that develop DP experience symptoms. 11,30,36,40,41,44 Rectal bleeding and rectal pain were reported as DP symptoms in 13 reports 11,18,25,26,29,31,40,41,44,48,49,56 and 7 reports, respectively.…”

Section: Clinical Presentationmentioning

confidence: 99%

“…11,48 Additionally, tenesmus, lower abdominal pain and mucous discharge may be present. 11,18,25,26,28,31,36,40,41,44,47,49,55,56…”

Section: Clinical Presentationmentioning

confidence: 99%

See 4 more Smart Citations

Diversion proctocolitis and the problem of the forgotten rectum in inflammatory bowel diseases: A systematic review

et al. 2021

Self Cite

View full text Add to dashboard Cite

Background and aims: Diversion proctocolitis (DP) is a non-specific mucosal inflammation arising in the defunctionalized colon and/or rectum following faecal diversion (colostomy, ileostomy). Differential diagnosis of DP from the underlying disease in patients with inflammatory bowel diseases (IBD) is often unclear. As a result, it might be difficult to undertake any specific treatment. We aimed to systematically review the literature evidence on DP in IBD patients.Methods: For this qualitative systematic review, we searched PubMed, EMBASE and Scopus to identify all studies published until July 2021 including IBD patients affected by DP.Results: Overall, 37 papers published between 1982 and 2021 were included. A total of 1.211 IBD patients were included: 613 UC (50.6%), 524 CD (43.3%), 66 IBDunclassified (IBD-U) (5.4%), 8 unspecified patients (0.7%). Most patients with DP are asymptomatic, although inflammation is detectable in almost all patients with a rectal stump. Reduced short-chain fatty acids and an altered microbiome, may trigger mucosal inflammation and have been proposed as causing factors. An increased risk of developing cancer on DP has been reported in patients with a history of previous dysplasia/cancer. Conclusions:The etiopathogenesis of DP is still unknown. The efficacy of mesalamine, corticosteroids or short-chain fatty acids has not been proven by randomized trials yet. Since the incidence of cancer of the rectal stump can reach 4.5 per 1.000 diverted patients-year, IBD patients undergoing subtotal colectomy with end-ileostomy should undergo close endoscopic surveillance, being eventually counseled for surgery with or without the restoration of the intestinal continuity.

show abstract