S100A12 is a promising biomarker in papillary thyroid cancer

Wang, Xiaojie; Sun, Zhenxiang; Tian, Wei; Piao, Chenghao; Xie, Xiaochen; Zang, Jin; Peng, Siyun; Yu, Xiao‐Juan; Wang, Yiwei

doi:10.1038/s41598-020-58534-1

Cited by 23 publications

(13 citation statements)

References 41 publications

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“…S100A12 belongs to calciumbinding S100 group proteins, which was necessary in cancer development. S100A12 was related to the proliferation and invasion of human papillary thyroid cancer (PTC), and may be an effective target for PTC treatment [34]. Meanwhile, S100A12 can be important diagnostic biomarker in breast cancer [35].…”

Section: Discussionmentioning

confidence: 99%

Identification the prognostic value of immune gene signature and infiltrating immune cells of esophageal cancer patients

Wang

Qian

Zhang

et al. 2020

Preprint

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Background Esophageal cancer (ESCA) is one of the deadliest solid malignancies with worse survival in the world. The poor prognosis of ESCA is not only related to malignant cells, but also affected by the microenvironment. We aimed to establish prognostic signature consisting of immune genes to predict the survival outcome of patients and estimate the prognosis value of infiltrating immune cells in tumor microenvironment (TME). Methods Based on integrated analysis of gene expression profiling and immune gene database, differentially immune-related genes were filtered out. Then, stepwise Cox regression analysis was applied to identify survival related immune genes and construct prognosis signature. Functional enrichment analysis was performed to explore biology function. Kaplan-Meier (K-M) curves and receiver operating characteristic (ROC) curves were performed to validate the predictive effect of predictive signature. We also verified the clinical value of prognostic signature under the influence of different clinical parameters. For deeper analysis, we evaluated the correlation between prognosis signature and infiltrating immune cells by Tumor Immune Estimation Resource (TIMER) and CIBERSORT. Results Finally, we identified 303 differentially immune genes as candidate and constructed immune prognosis signature composed of six immune genes. Furthermore, we observed that the prognosis signature was enriched in cytokine-mediated signaling pathway, lymphocyte activation, immune effector process, cancer pathway, NF-kappa B signaling pathway. K-M survival curves showed that the prognosis signature indeed have good predictive ability in entire ESCA set ( P =0.003), validation set 1 ( P =0.008) and validation set 2 ( P =0.036). The area under the curve (AUC) of ROC curves validated the predictive accuracy of immune signature in three cohorts (AUC=0.757, 0.800 and 0.701), respectively. In addition, we identified the prognosis value of infiltrating-immune cells including activated memory CD4 T cells, T cells follicular helper cells and monocytes and provided a landscape of TME. Conclusions The results indicated that immune prognosis signature can be a novel biomarker to predict survival outcome, which can provide new targets for immunotherapy and individualized therapies in ESCA and open up a new prospect for improving the prognosis of ESCA patients in the era of immunotherapy.

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Section: Discussionmentioning

confidence: 99%

Identification the prognostic value of immune gene signature and infiltrating immune cells of esophageal cancer patients

Wang

Qian

Zhang

et al. 2020

Preprint

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“…S100A12 is an important protein for evaluating the activity of several inflammatory diseases. This protein is distinctively increased in diseases such as systemic juvenile idiopathic arthritis and FMF, although it is also elevated in infection, malignancy, and some collagen diseases [9][10][11][12][13][14]16,17]. In a study of 56 children and adolescents with FMF, S100A12 levels had better indicative power than CRP level, ESR, and SAA level.…”

Section: Discussionmentioning

confidence: 99%

“…The activation of this receptor induces the proinflammatory response via nuclear factor-kappa B in leukocytes and endothelial cells, and this protein is reportedly a marker for granulocyte activation that is more useful than CRP and ESR for detecting inflammatory activity. The amount of S100A12 protein is also known to increase in cases of malignancies, obstructive sleep apnea, autoimmune diseases, systemic lupus erythematosus, juvenile arthritis, and FMF [10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of S100A12 protein levels in children with familial Mediterranean fever

Türkmenoğlu¹,

Güney²,

Bezen³

et al. 2021

Turk J Med Sci

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Background/aim: Familial Mediterranean fever (FMF), the most common autoinflammatory disease in children, is characterized by recurrent febrile episodes. FMF is known to progress with chronic inflammation, particularly during attack periods. This study aimed to investigate the relationship of S100A12, an inflammatory marker, with attacks and inflammatory events in FMF patients. Materials and methods: The study included 57 patients diagnosed with FMF, 43 in an attack-free period and 14 in an attack period, and 31 healthy children as the control group. Only white blood cell (WBC) count, C-reactive protein (CRP) level, erythrocyte sedimentation rate (ESR), and S100A12 level were analyzed in the control group. In addition, serum amyloid A (SAA), and fibrinogen levels were measured, and a mutation analysis was performed in the patient group. The results were compared among the attackfree period, acute attack FMF and control groups. Results: The mean age of patients and control group was 10 (2.5-18) and 9.5 (2.5-16) years, respectively. The CRP (p = 0.001), S100A12 (p = 0.003) and ESR (p= 0.001) values differed significantly between the FMF and control groups. S100A12 level (p = 0.027), WBC count (p = 0.003), CRP level (p = 0.0001), ESR (p = 0.004), and fibrinogen level (p = 0.001) differed significantly between the acute attack and attack-free period groups. SAA level (p = 0.05), ESR (p = 0.001), fibrinogen level (p = 0.001), WBC count (p = 0.001), and S100A12 level (p = 0.027) were higher in M694V homozygous FMF patients than in other FMF patients. 2 Conclusion: Patients with FMF had higher S100A12 levels than the control group, while the mean S100A12 concentration was higher in acute attack period patients than in attackfree period patients. S100A12 level might be an important indicator in the monitoring of chronic inflammation in patients with FMF.

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“…S100A12 is commonly expressed on neutrophils monocytes and macrophages, the plasma levels of S100A12 are systemic biomarkers for many inflammatory diseases ( Meijer et al, 2012 ). S100A12 is dysregulated in many types of cancers, upregulated in colorectal cancer and papillary thyroid cancer but reduced in gastric carcinoma and oropharyngeal squamous cells ( Thierolf et al, 2008 ; Funk et al, 2015 ; Li et al, 2016 ; Wang et al, 2020 ). Studies on S100A12 in HCC are limited.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Analysis of the Prognosis and Correlations With Immune Infiltration of S100 Protein Family Members in Hepatocellular Carcinoma

et al. 2021

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S100 protein family members (S100s) are commonly dysregulated in various tumors including hepatocellular carcinoma (HCC). However, the diverse expression, mutation, prognosis and associations with immune infiltration of S100s in HCC have yet to be analyzed. Herein we investigated the roles of S100s in HCC from the Oncomine, Gene Expression Profiling Interactive Analysis (GEPIA), Human Protein Atlas, Kaplan-Meier Plotter, cBioPortal and TIMER databases. Compared with para-cancer tissues, the expression levels of S100A4/S100A6/S100A10/S100A11/S100A13/S100A14/S100P were higher in HCC tissues, while the expression levels of S100A8/S100A9/S100A12 were decreased in tumor tissues. The mRNA levels of S100A2/S100A7/S100A7A/S100A8/S100A9/S100A11 were correlated with advanced tumor stage. Besides, higher mRNA expressions of S100A6/S100A10/S100A11/S100A13/S100A14/S100P were shown to have shorter overall survival (OS), while higher expression of S100A12 was associated with favorable OS. Further, the mutation rate of S100s was investigated, and the high mutation rate (53%) was associated with shorter OS. Additionally, the expressions of S100s were found to be significantly associated with various immune infiltrating cells. Hence, our results showed that S100A6/S100A10/S100A11/S10012/S100A13/S100A14/S100P may be regarded as new prognostic or therapeutic markers and S100s inhibitors may be helpful in the combination of immunotherapies.

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S100A12 is a promising biomarker in papillary thyroid cancer

Cited by 23 publications

References 41 publications

Identification the prognostic value of immune gene signature and infiltrating immune cells of esophageal cancer patients

Identification the prognostic value of immune gene signature and infiltrating immune cells of esophageal cancer patients

Evaluation of S100A12 protein levels in children with familial Mediterranean fever

Comprehensive Analysis of the Prognosis and Correlations With Immune Infiltration of S100 Protein Family Members in Hepatocellular Carcinoma

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