Sa1183: SALIVARY CYTOKINES REVEAL A TYPE 2 INFLAMMATORY PROILE IN EOSINOPHILIC ESOPHAGITIS

Ro, Gabrielle; Pyne, Ashley L.; Hazel, Mark W.; Uchida, Amiko M.; Peterson, Kathryn A.

doi:10.1016/s0016-5085(22)60810-2

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Patient Secretions1

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2022

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“…In a cohort of 20 pediatric patients with atopy (9 of whom had EoE), investigators detected IL-4, IL-5, IL-13, eotaxin-3 and TSLP (54). Similarly, in a small cohort of active EoE, resolved EoE and non-EoE controls, several type 2 inflammatory cytokines were significantly elevated in the saliva of patients with active vs resolved EoE (55).…”

Section: Patient Secretionsmentioning

confidence: 96%

Models and Tools for Investigating Eosinophilic Esophagitis at the Bench

Uchida

Garber

et al. 2022

Front. Immunol.

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Eosinophilic esophagitis (EoE) is an increasingly common food allergy disease of the esophagus that received its medical designation code in 2008. Despite this recency, great strides have been made in the understanding of EoE pathophysiology and type 2 immunity through basic and translational scientific investigations conducted at the bench. These advances have been critical to our understanding of disease mechanisms and generating new hypotheses, however, there currently is only one very recently approved FDA-approved therapy for EoE, leaving a great deal to be uncovered for patients with this disease. Here we review some of the innovative methods, models and tools that have contributed to the advances in EoE discovery and suggest future directions of investigation to expand upon this foundation.

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Section: Patient Secretionsmentioning

confidence: 96%