Sa1399 Associations Between Gastric Phase 3 Contractions, Hunger Peaks and Voluntary Meal Intake in Healthy Volunteers

Deloose, Eveline; Janssen, Pieter; Oudenhove, Lukas Van; Bergh, Omer Van den; Depoortere, Inge; Tack, Jan

doi:10.1016/s0016-5085(12)61106-8

Cited by 3 publications

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“…Its role might be more comprehensive as changes in interdigestive motility have been reported in several functional gastrointestinal disorders such as IBS, functional dyspepsia, gastroparesis, etc . Furthermore, ongoing studies from our group reported a sharp increase in hunger scores during spontaneous gastric phase III contractions in humans . Although ghrelin is known to be a potent orexigenic signal, the lack of fluctuation of ghrelin during the MMC would suggest that ghrelin does not increase hunger by inducing gastric phase III contractions.…”

Section: Discussionmentioning

confidence: 81%

“…8 Furthermore, ongoing studies from our group reported a sharp increase in hunger scores during spontaneous gastric phase III contractions in humans. [52][53][54] Although ghrelin is known to be a potent orexigenic signal, the lack of fluctuation of ghrelin during the MMC would suggest that ghrelin does not increase hunger by inducing gastric phase III contractions. As motilin is the key regulator of gastric phase III contractions it is conceivable that motilin contributes to hunger signal-ing during the MMC, but this will require further studies in humans.…”

Section: Discussionmentioning

confidence: 99%

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Endogenous motilin, but not ghrelin plasma levels fluctuate in accordance with gastric phase III activity of the migrating motor complex in man

Deloose

Vos

Corsetti

et al. 2014

Neurogastroenterology Motil

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Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Endogenous motilin, but not ghrelin plasma levels fluctuate in accordance with gastric phase III activity of the migrating motor complex in man

Deloose

Vos

Corsetti

et al. 2014

Neurogastroenterology Motil

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The combination of L‐menthol and caraway oil does not affect gastric function but increases hunger in healthy subjects

Masuy,

Verbeure,

Ruilova Sosoranga

et al. 2024

Neurogastroenterology Motil

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BackgroundThe heterogeneous character of functional gastrointestinal disorders, recently renamed into disorders of gut‐brain interaction, makes finding effective treatment options challenging. Compared to synthetic drugs, phytotherapy can have broader pharmacological effects and is often better tolerated. This study aimed to investigate the effect of peppermint oil and caraway oil (POCO) on gastric function and symptom levels in 32 healthy subjects in a single‐blinded, placebo‐controlled, randomized, parallel design.MethodsGastric emptying rate was assessed using a 13C‐breath test. Intragastric pressure was measured using high‐resolution manometry in fasted state and during intragastric infusion of a nutrient drink (350 mL or until full satiation). GI symptoms were rated on a 100 mm VAS. Data were analyzed using linear mixed models.Key ResultsPOCO had no effect on intragastric pressure in fasted or fed state (p > 0.08 for all). No significant differences in gastric emptying rate were observed (p = 0.54). In the fasted state, a stronger increase in hunger and decrease in satiety were observed following POCO (p = 0.016 and p = 0.008, respectively). No differences in hunger and satiety were observed in the fed state (p > 0.31 for all). POCO induced less epigastric burning, bloating, and fullness (p < 0.05 for all).ConclusionsAcute POCO administration did not affect gastric function in healthy subjects, but increased fasted hunger ratings. The effects of POCO on gastric function and hunger sensations in patients with disorders of gut‐brain interaction, and the contribution to symptom improvement, needs to be elucidated in future studies.

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Motilin-induced gastric contractions signal hunger in man

Tack

Deloose

Ang

et al. 2014

Gut

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Sa1399 Associations Between Gastric Phase 3 Contractions, Hunger Peaks and Voluntary Meal Intake in Healthy Volunteers

Cited by 3 publications

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Endogenous motilin, but not ghrelin plasma levels fluctuate in accordance with gastric phase III activity of the migrating motor complex in man

Endogenous motilin, but not ghrelin plasma levels fluctuate in accordance with gastric phase III activity of the migrating motor complex in man

The combination of L‐menthol and caraway oil does not affect gastric function but increases hunger in healthy subjects

Motilin-induced gastric contractions signal hunger in man

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