Sa1840 Effects of Oral L-Carnitine on Liver Functions After Transarterial Chemoembolization (TACE) in Intermediate Stage Hepatocellular Carcinoma (HCC) Patients.

Hassan, Abeer A.; Tsuda, Yasuhiro; Asai, Akira; Yokohama, Keisuke; Ohama, Hideko; Nakamura, Ken; Sujishi, Tetsuya; Tsuchimoto, Yusuke; Fukunishi, Shinya; Malak, Mohamed; Arafa, Usama Ahmed; Hassan, Ali T.; Kassem, Ali; Higuchi, Kazuhide

doi:10.1016/s0016-5085(15)33492-2

Cited by 1 publication

(7 citation statements)

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“…Some of the RCTs examined whether the consumption of a BCAA-enriched nutrient mixture helped to maintain or improve liver function in individuals with cancer (Hassan et al, 2015; Morihara et al, 2012). BCAAs were consumed during the day or as a late evening snack, dependent on the study.…”

Section: Literature Review Resultsmentioning

confidence: 99%

“…Results show consumption of a late-evening snack with a BCAA supplementation may significantly and rapidly improve liver function and Child-Pugh scores in individuals with hepatocellular carcinoma (HCC) after undergoing RFA. Moreover, results indicate that BCAA supplementation with food or as a snack can help reduce malnourishment in individuals with cancer by increasing their calorie and protein intakes (Deutz et al, 2011; Hassan et al, 2015; Morihara et al, 2012). As nutrient intakes improve, malnourishment, which is a common side effect of anticancer therapies, is improved and individuals may have an increased quality of life.…”

Section: Literature Review Resultsmentioning

confidence: 99%

“…If the supplementation of BCAAs can increase these individual's intakes to help them meet their nutritional needs, side effects from anticancer therapies such as reduced appetite, malnourishment, and reduced quality of life could be improved. In fact, many of the RCTs showed that BCAA supplementation was able to improve appetite and intakes in these individuals (Deutz et al, 2011;Hassan et al, 2015;Morihara et al, 2012). Some of the RCTs examined whether the consumption of a BCAA-enriched nutrient mixture helped to maintain or improve liver function in individuals with cancer (Hassan et al, 2015;Morihara et al, 2012).…”

Section: Increased Caloric Intakementioning

confidence: 99%

“…In fact, many of the RCTs showed that BCAA supplementation was able to improve appetite and intakes in these individuals (Deutz et al, 2011;Hassan et al, 2015;Morihara et al, 2012). Some of the RCTs examined whether the consumption of a BCAA-enriched nutrient mixture helped to maintain or improve liver function in individuals with cancer (Hassan et al, 2015;Morihara et al, 2012). BCAAs were consumed during the day or as a late evening snack, dependent on the study.…”

Section: Increased Caloric Intakementioning

confidence: 99%

“…It is clear in the current literature that evidence is divided regarding the use of BCAA supplementation in individuals with cancer. Some research supports the benefits of BCAA supplementation, including improved recovery after chemotherapy marked by weight gain and increased energy levels (Deutz et al, 2011; Hachiya et al, 2020; Hassan et al, 2015; Katagiri et al, 2020; Kikuchi et al, 2016; Morihara et al, 2012; Nojiri et al, 2017; Storck et al, 2020; Tada et al, 2015; Yoshiji et al, 2013). On the other hand, other recent studies have reported that BCAA supplementation can be extremely harmful to individuals with cancer because cells can feed off BCAAs and stay alive even in anaerobic environments (Ananieva and Wilkinson, 2018; Ericksen et al, 2019; Lei et al, 2020; Lieu et al, 2020; Peng et al, 2020; Taherizadeh et al, 2021; Wang et al, 2018).…”

Section: Introductionmentioning

confidence: 95%

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The effect of branched-chain amino acid supplementation on cancer treatment

Lee

Blanton

2023

Nutr Health

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Background: Anticancer therapies are associated with significant adverse side effects and few treatments that alleviate symptoms exist. Branched-chain amino acids (BCAAs) have been investigated as an intervention for reducing anticancer therapy side effects, although a review of the literature results has yet to be published. Aim: The current review summarizes evidence surrounding this topic and suggests both support and caution in using BCAAs as a treatment for patients receiving anticancer therapies. Methods: In this review, two literature searches were completed. Google Scholar, PubMed, EBSCOhost, and Cochrane databases were searched using the terms “branched-chain amino acids and cancer” and “BCAA and cancer.” Results: Two bodies of evidence emerged: One supporting beneficial effects and the other showing adverse outcomes of BCAA supplementation in patients with cancer. Evidence of benefit was a decrease in malnourishment and unintentional weight loss during and after chemotherapy. Potential harms included the idea cancer cells may utilize BCAAs as a source of energy for growth. Conclusions: Supplementation of BCAAs in individuals with cancer should be implemented cautiously. Those who are severely malnourished due to anticancer therapy may benefit the most. BCAA supplementation may also be provided once cancer has been destroyed from the individual's body to aid with recovery.

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Section: Literature Review Resultsmentioning

confidence: 99%