Sacral Hemangiomas and Multiple Congenital Abnormalities

Goldberg, Neil S.

doi:10.1001/archderm.1986.01660180090022

Cited by 135 publications

(32 citation statements)

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“…By consequence, tails are often not detected before neurologic clinical manifestations. 11,[22][23][24][25]32,33 In our study, a dermal sinus was associated with OSD in 4 of 4 patients (Table 1; Figure 1B and Figure 2A). All 5 patients underwent surgical exploration because dermal sinuses carry a high risk of cerebrospinal fluid infection or intradural abscesses.…”

Section: Commentmentioning

confidence: 69%

“…However, the description of strawberry nevi was insufficient to classify according to ISSVA. In a report of 5 patients with lumbosacral hemangioma combined with other developmental anomalies, Goldberg et al 11 considered such hemangiomas as cutaneous markers of OSD (Figure 2A). Albright et al 12 described 7 neurologically normal infants with lumbosacral hemangiomas, all of whom had a tethered spinal cord.…”

Section: Commentmentioning

confidence: 99%

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Skin Markers of Occult Spinal Dysraphism in Children

Guggisberg¹,

Hadj‐Rabia²,

Viney³

et al. 2004

Arch Dermatol

224

151

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To verify the diagnostic value of lumbosacral midline cutaneous lesions in asymptomatic children to detect occult spinal dysraphism (OSD) and to propose a practical approach for clinical investigations with respect to the type of cutaneous lesions observed.Design: Retrospective study of 54 children referred to the Department of Pediatric Dermatology between 1990 and 1999 for congenital midline lumbosacral cutaneous lesions.Setting: The private or institutional practices of participating dermatologists and pediatricians.Main Outcome Measures: Evaluation of the diagnostic value of midline cutaneous lesions for the detec-tion of OSD. Association of skin examination findings with spinal anomalies detected by magnetic resonance imaging or ultrasound.Results: Occult spinal dysraphism was detected in 3 of 36 patients with an isolated congenital midline lesion and 11 of 18 patients with a combination of 2 or more different skin lesions.Conclusions: A combination of 2 or more congenital midline skin lesions is the strongest marker of OSD. Careful dermatologic examination is needed to detect suggestive markers and request a spinal magnetic resonance image, which is the most sensitive radiologic approach to detect an OSD.

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Section: Commentmentioning

confidence: 69%

Section: Commentmentioning

confidence: 99%

Skin Markers of Occult Spinal Dysraphism in Children

Guggisberg¹,

Hadj‐Rabia²,

Viney³

et al. 2004

Arch Dermatol

224

151

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show abstract

“…45 Although the sensitivity and specificity of the lumbosacral midline infantile hemangioma as a marker for spinal dysraphism are not entirely known, the presence of this marker raises suspicion for an underlying dysraphic malformation. 43,45,46 A subset of infantile hemangiomas overlying the lumbosacral spine that are segmental, are large, and may have a reticular pattern are associated with spinal and genital urinary malformations in up to 55% of cases as part of the LUMBAR syndrome (lower body hemangioma and other cutaneous defects, urogenital abnormalities, ulcerations, myelopathy, bony defects, anorectal malformations, arterial anomalies, and renal anomalies). 47 Caudal appendages represent focal skin-covered appendages described as true tails and pseudotails 48 (Fig 16).…”

Section: E1114mentioning

confidence: 99%

Congenital Brain and Spinal Cord Malformations and Their Associated Cutaneous Markers

Dias

Partington²

2015

Pediatrics

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the SECTION ON NEUROLOGIC SURGERY abstract The brain, spinal cord, and skin are all derived from the embryonic ectoderm; this common derivation leads to a high association between central nervous system dysraphic malformations and abnormalities of the overlying skin. A myelomeningocele is an obvious open malformation, the identification of which is not usually difficult. However, the relationship between congenital spinal cord malformations and other cutaneous malformations, such as dimples, vascular anomalies (including infantile hemangiomata and other vascular malformations), congenital pigmented nevi or other hamartomata, or midline hairy patches may be less obvious but no less important. Pediatricians should be aware of these associations, recognize the cutaneous markers associated with congenital central nervous system malformations, and refer children with such markers to the appropriate specialist in a timely fashion for further evaluation and treatment.

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“…Associated abnormalities included anomalies characteristic of PHACE syndrome (posterior fossa brain malformations, hemangiomas, arterial anomalies, coarctation of the aorta and cardiac defects, and eye abnormalities), 14 urogenital abnormalities, 15 spinal involvement (such as tethered spinal cord or hemangioma tissue radiologically involving the deep paraspinal tissue), 15 and mediastinal hemangiomas. They also included other abnormalities such as cardiac defects without other evidence of PHACE syndrome and other structural or developmental abnormalities such as limb hypertrophy or cleft palate.…”

Section: Associated Abnormalitiesmentioning

confidence: 99%