Sacrococcygeal teratoma: The experience of four decades

Schropp, Kurt P.; Lobe, Thom E.; Rao, Bhaskar N.; Mutabagani, Khaled; Kay, Gail A.; Gilchrist, Brian; Philippe, Paul; Boles, E. Thomas

doi:10.1016/0022-3468(92)90563-m

Cited by 140 publications

(97 citation statements)

References 10 publications

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“…Sacrococcygeal teratomas are most commonly seen as congenital neoplasms with an incidence of B1:35 000-40 000 of live births. 11 These tumors are much less common in adults and are thought to represent either a previously undetected or an incompletely excised congenital tumor. 12 Only limited studies examining sacrococcygeal teratomas for genetic abnormalities have been performed, and almost none in adults.…”

Section: Discussionmentioning

confidence: 99%

Sacrococcygeal teratomas: clinico-pathological characteristics and isochromosome 12p status

et al. 2014

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The biological behavior of teratomas is highly variable, and morphologic features alone are insufficient to predict their clinical course. Prognostic factors that influence behavior include the following: patient sex, age, anatomic site, coincident neoplasm, and cytogenetic abnormalities. Gonadal teratomas have been wellcharacterized; postpubertal testicular teratomas are commonly associated with isochromosome 12p (i12p) and considered to nearly always carry a potential for malignant behavior, whereas ovarian and prepubertal testicular teratomas are i12p negative and predominantly benign in behavior. For extragonadal sites, such as sacrum and coccyx, clinical characteristics and i12p status are yet to be adequately characterized. As part of this study, we identified 19 sacrococcygeal teratomas in our surgical pathology archives from 1990 to 2012. Clinical records and slides were reviewed to confirm the original diagnosis. Gains in chromosome 12p, including i12p status were assessed in representative paraffin sections by fluorescence in situ hybridization. Our cases included 16 mature sacrococcygeal teratomas (11 prepubertal and 5 postpubertal) and three immature saccrococygeal teratomas (all prepubertal). Among mature teratomas, the average tumor size was larger in adults compared with prepubertal patients. A higher number of adult cases were recurrences (80% vs 21%), but only pediatric recurrences were managed with postoperative chemotherapy. All examined tumors were negative for i12p. 100% survival was documented in our cohort with a median follow-up of 6 years. We present a large series of sacrococcygeal teratomas and the first series to examine postpubertal adults at this anatomic site. All tumors lacked chromosome 12p gains, including i12p. Both pre-and postpubertal sacrococcygeal teratomas had a favorable outcome regardless of age or sex.

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Section: Discussionmentioning

confidence: 99%

Sacrococcygeal teratomas: clinico-pathological characteristics and isochromosome 12p status

et al. 2014

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“…There are commonly benign and asymptomatic and they could rarely produce a strange and different clinical picture, depending of the germinal cells different potential. We frequently find teratomas in children at the level of the sacrococcygeal region (up to 40%), gonadal, mediastinal, retroperitoneal, liver or central nervous system [3,4,5].…”

Section: Introductionmentioning

confidence: 99%

“…2% of reported cases). At the level of the head and neck, teratomas are placed in: central nervous system, orbit, infratemporal fossa, oropharynx, nasopharynx, nasal cavity, palatine bone or palatin tonsil [2,3,6].…”

Section: Introductionmentioning

confidence: 99%

Giant Tonsil Teratoma

Dincã¹

2017

ARS Medica Tomitana

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“…4 Of those who are born, survival is much improved (although preselection may occur) and is in the range of 90%. Reviewing 541 cases of SCT that were published through the years in the Journal of Pediatric Surgery, [5][6][7][8][9][10][11] there were 31 (5.7%) operative or immediate postoperative deaths. Of these 31, 4 were documented as having cardiac arrest, and 8 were classified as "unknown cause."…”

Section: Discussionmentioning

confidence: 99%

Progressive Tumor Necrosis and Lethal Hyperkalemia in a Neonate With Sacrococcygeal Teratoma (SCT)

Jona

1999

J Perinatol

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Sacrococcygeal teratoma: The experience of four decades

Cited by 140 publications

References 10 publications

Sacrococcygeal teratomas: clinico-pathological characteristics and isochromosome 12p status

Sacrococcygeal teratomas: clinico-pathological characteristics and isochromosome 12p status

Giant Tonsil Teratoma

Progressive Tumor Necrosis and Lethal Hyperkalemia in a Neonate With Sacrococcygeal Teratoma (SCT)

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