Sacroiliitis in Axial Spondyloarthritis: Assessing Morphology and Activity

Jans, Lennart; Egund, Niels; Eshed, Iris; Sudoł‐Szopińska, Iwona; Jurik, Anne Grethe

doi:10.1055/s-0038-1639470

Cited by 20 publications

(6 citation statements)

References 52 publications

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“…In the current work, the agreement between the 2 readers regarding erosion of the symphysis pubis was moderate, perhaps because erosion may be difficult to assess on T1-weighted MRI sequences. 10 The level of acute phase proteins and ESR level were higher in patients with active inflammatory changes of the symphysis pubis than in those without active inflammatory changes in our study. The elevated acute phase proteins noted in the patients with active inflammation of the symphysis pubis supported the fact that the signal intensity abnormalities may have likely resulted from an inflammatory process rather than a mechanical one.…”

Section: Discussioncontrasting

confidence: 40%

“…In addition, further studies comparing radiologic and MRI changes of the symphysis pubis are needed. In the current work, the agreement between the 2 readers regarding erosion of the symphysis pubis was moderate, perhaps because erosion may be difficult to assess on T1-weighted MRI sequences 10 …”

Section: Discussionmentioning

confidence: 63%

“…Sclerosis was defined as area with very low signal intensity on all sequences located in the subchondral bone with a depth of at least 5 mm. Ankylosis was defined as bony bridges or confluent high T1 signal intensity bridging across the joint space to connect between the pubis on both sides 10 …”

Section: Methodsmentioning

confidence: 99%

“…Ankylosis was defined as bony bridges or confluent high T1 signal intensity bridging across the joint space to connect between the pubis on both sides. 10…”

Section: Mri Scan Analysismentioning

confidence: 99%

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MRI Changes of the Symphysis Pubis in Patients With Axial Spondyloarthritis and Association With Clinical Factors

Yan¹,

Qiao

Jin³

et al. 2021

J Comput Assist Tomogr

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Objective: This study aimed to evaluate the magnetic resonance imaging (MRI) changes of the symphysis pubis in patients with axial spondyloarthritis (ax-SpA) and to assess its association with clinical factors.Methods: A retrospective analysis of 172 patients with ax-SpA was performed to assess the presence of active inflammatory and structural changes of the symphysis pubis on MRI scans, and their association with clinical factors and the SPARCC (Spondyloarthritis Research Consortium of Canada) scoring of the sacroiliac joint were evaluated. Results:The proportions of active inflammation and structural changes of the symphysis pubis were 69/172 (40.1%) and 54/172 (31.4%), respectively. When comparing the active inflammation and no-active inflammation symphysis pubis groups, the former had higher level C-reactive protein, higher erythrocyte sedimentation rate, and younger median age of patients. Moreover, no significant correlation was noted between the active inflammation of the symphysis pubis and SPARCC score of the sacroiliac joint. When comparing the normal and abnormal symphysis pubis groups, the latter had longer symptom duration. Conclusions:The MRI changes of the symphysis pubis were seen in 55.2% of the patients with ax-SpA and were associated with C-reactive protein, erythrocyte sedimentation rate, and symptom duration.

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Section: Discussioncontrasting

confidence: 40%

Section: Discussionmentioning

confidence: 63%

Section: Methodsmentioning

confidence: 99%

“…Ankylosis was defined as bony bridges or confluent high T1 signal intensity bridging across the joint space to connect between the pubis on both sides. 10…”

Section: Mri Scan Analysismentioning

confidence: 99%

See 2 more Smart Citations

MRI Changes of the Symphysis Pubis in Patients With Axial Spondyloarthritis and Association With Clinical Factors

Yan¹,

Qiao

Jin³

et al. 2021

J Comput Assist Tomogr

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“…Bone Marrow Edema (BME) is relatively easy to depict on short tau inversion recovery (STIR) images and has a high sensitivity in the diagnosis of SpA. However, the extent of the lesion cannot be quantified [ 13 , 14 ]. Therefore, the application of new MRI scanning technologies like IVIM-DWI and DCE-MRI can gradually compensate for these shortcomings.…”

Section: Discussionmentioning

confidence: 99%

Comparative study of imaging and histology of sacroiliac joint in normal rats based on IVIM-DWI and DCE-MRI

Qin

Yao

et al. 2020

BMC Musculoskelet Disord

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Background: Currently, few studies have described the relationship between functional MRI findings and histology of normal sacroiliac joint (SIJ). Besides, due to the difficulties in access to SIJ, authentic animal models are important in providing opportunities for quantitative parameter extraction on imaging. Aims: This study aimed at exploring the parameters of Intravoxel Incoherent Motion Diffusion-Weighted Imaging (IVIM-DWI) and Dynamic Contrast-Enhanced Magnetic Resonance Imaging (DCE-MRI) and comparing them with the histology of the SIJ in normal rats with different ages. Methods: A total of thirty 7-week-old male Wistar rats were included in the study. The parameters of IVIM-DWI and DCE-MRI in the bone marrow and the joint space of SIJ were measured at 8, 13, 18, 23, 28, and 33 weeks. The histological analysis of the SIJ was examined using light microscopy. One-way ANOVA was used for statistical analysis. Results: The D values in the sacral and iliac bone marrow of normal rats decreased with an increase in age. One-way ANOVA analysis indicated a significant difference in D values in different age groups (P<0.005). The normal values of D*, f, Fenh (%), Senh (%/s) in the sacral bone marrow, the iliac bone marrow, and the joint space in SIJ of normal rats were obtained. The results showed that in the six groups of rats of different ages, the histology of the SIJ surface was smooth and clear, the cartilage cells were intact, and no thickening or pannus formation was observed. Conclusions: This study obtained the IVIM-DWI and DCE-MRI parameters of the sacral and iliac bone marrow and the synovial area of the joint space in normal rats. The parameters in normal rats can be used in future research to compare to similar parameters in animal models or patients with SIJ diseases. This study serves as a guide for future research in SIJ diseases.

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Magnetic Resonance Imaging Versus Computed Tomography for Three‐Dimensional Bone Imaging of Musculoskeletal Pathologies: A Review

Florkow

Willemsen

Mascarenhas

et al. 2022

Magnetic Resonance Imaging

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Magnetic resonance imaging (MRI) is increasingly utilized as a radiation‐free alternative to computed tomography (CT) for the diagnosis and treatment planning of musculoskeletal pathologies. MR imaging of hard tissues such as cortical bone remains challenging due to their low proton density and short transverse relaxation times, rendering bone tissues as nonspecific low signal structures on MR images obtained from most sequences. Developments in MR image acquisition and post‐processing have opened the path for enhanced MR‐based bone visualization aiming to provide a CT‐like contrast and, as such, ease clinical interpretation. The purpose of this review is to provide an overview of studies comparing MR and CT imaging for diagnostic and treatment planning purposes in orthopedic care, with a special focus on selective bone visualization, bone segmentation, and three‐dimensional (3D) modeling. This review discusses conventional gradient‐echo derived techniques as well as dedicated short echo time acquisition techniques and post‐processing techniques, including the generation of synthetic CT, in the context of 3D and specific bone visualization. Based on the reviewed literature, it may be concluded that the recent developments in MRI‐based bone visualization are promising. MRI alone provides valuable information on both bone and soft tissues for a broad range of applications including diagnostics, 3D modeling, and treatment planning in multiple anatomical regions, including the skull, spine, shoulder, pelvis, and long bones. Level of Evidence 3 Technical Efficacy Stage 3

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Sacroiliitis in Axial Spondyloarthritis: Assessing Morphology and Activity

Abstract: Active lesions remain the hallmark for assessment of inflammation in sacroiliitis. Structural lesions increasingly play a role in the diagnosis of spondyloarthritis.

Cited by 20 publications

References 52 publications

MRI Changes of the Symphysis Pubis in Patients With Axial Spondyloarthritis and Association With Clinical Factors

MRI Changes of the Symphysis Pubis in Patients With Axial Spondyloarthritis and Association With Clinical Factors

Comparative study of imaging and histology of sacroiliac joint in normal rats based on IVIM-DWI and DCE-MRI

Magnetic Resonance Imaging Versus Computed Tomography for Three‐Dimensional Bone Imaging of Musculoskeletal Pathologies: A Review

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