Safe Nanoparticles: Are We There Yet?

Najahi‐Missaoui, Wided; Arnold, Robert D.; Cummings, Brian S.

doi:10.3390/ijms22010385

Cited by 322 publications

(213 citation statements)

References 179 publications

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“…Instead, biodegradable polymeric nanoparticles degrade into small molecules, release their cargo, and should be easily cleared by the body [ 138 ]. Moreover, although biodegradable nanoparticles are still not commercially licensed for use in poultry, two common polymers, chitosan and PVM/MA, have already been approved by the FDA for clinical use [ 139 ]; which favors their approval for use in poultry. Nevertheless, regardless of the material used to synthesize the nanoparticles, all licensed nanoparticles should be studied thoroughly for biocompatibility and the safety of the host and the consumer.…”

Section: Conclusion and Recommendations: Future Of Polymeric Nanoparticles In The Broiler Industrymentioning

confidence: 99%

A Novel Approach against Salmonella: A Review of Polymeric Nanoparticle Vaccines for Broilers and Layers

et al. 2021

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This work discusses the present-day limitations of current commercial Salmonella vaccines for broilers and layers and explores a novel approach towards poultry vaccination using biodegradable nanoparticle vaccines against Salmonella. With the increasing global population and poultry production and consumption, Salmonella is a potential health risk for humans. The oral administration of killed or inactivated vaccines would provide a better alternative to the currently commercially available Salmonella vaccines for poultry. However, there are currently no commercial oral killed-vaccines against Salmonella for use in broilers or layers. There is a need for novel and effective interventions in the poultry industry. Polymeric nanoparticles could give way to an effective mass-administered mucosal vaccination method for Salmonella. The scope of this work is limited to polymeric nanoparticles against Salmonella for use in broilers and layers. This review is based on the information available at the time of the investigation.

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Section: Conclusion and Recommendations: Future Of Polymeric Nanoparticles In The Broiler Industrymentioning

confidence: 99%

A Novel Approach against Salmonella: A Review of Polymeric Nanoparticle Vaccines for Broilers and Layers

et al. 2021

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“…The size of plastic particles also affects their interaction with human cells [107]. Due to their high specific surface areas, the nanoparticle-cell interaction is vastly different compared to larger particles.…”

Section: Cellular Uptake and Intracellular Fate Of Microplastic And Nmentioning

confidence: 99%

“…Due to their high specific surface areas, the nanoparticle-cell interaction is vastly different compared to larger particles. Furthermore, the charge of the particle can also affect its interaction with the cell and its structure [107]. Since most of the in vitro studies described here have used polystyrene particles, it is difficult to extrapolate the results to other kinds of plastic particles.…”

Section: Cellular Uptake and Intracellular Fate Of Microplastic And Nmentioning

confidence: 99%

Impact of Microplastics and Nanoplastics on Human Health

et al. 2021

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Plastics have enormous impacts to every aspect of daily life including technology, medicine and treatments, and domestic appliances. Most of the used plastics are thrown away by consumers after a single use, which has become a huge environmental problem as they will end up in landfill, oceans and other waterways. These plastics are discarded in vast numbers each day, and the breaking down of the plastics from micro- to nano-sizes has led to worries about how toxic these plastics are to the environment and humans. While, there are several earlier studies reported the effects of micro- and nano-plastics have on the environment, there is scant research into their impact on the human body at subcellular or molecular levels. In particular, the potential of how nano-plastics move through the gut, lungs and skin epithelia in causing systemic exposure has not been examined thoroughly. This review explores thoroughly on how nanoplastics are created, how they behave/breakdown within the environment, levels of toxicity and pollution of these nanoplastics, and the possible health impacts on humans, as well as suggestions for additional research. This paper aims to inspire future studies into core elements of micro- and nano-plastics, the biological reactions caused by their specific and unusual qualities.

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“…Nanoparticles may pose toxicity issues through distribution and deposition in cells and different organ systems, such as the lungs, liver, and brain. The route of administration and exposure can influence the toxicity of NPs, and the toxicity of NPs is mainly determined by size, surface area, surface charge, and aggregation state [148]. Therefore, the toxicity of NPs should be considered and analyzed before use.…”

Section: Prospect and Challengesmentioning

confidence: 99%

Effect of Micro-/Nanoparticle Hybrid Hydrogel Platform on the Treatment of Articular Cartilage-Related Diseases

Shan

et al. 2021

Gels

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Joint diseases that mainly lead to articular cartilage injury with prolonged severe pain as well as dysfunction have remained unexplained for many years. One of the main reasons is that damaged articular cartilage is unable to repair and regenerate by itself. Furthermore, current therapy, including drug therapy and operative treatment, cannot solve the problem. Fortunately, the micro-/nanoparticle hybrid hydrogel platform provides a new strategy for the treatment of articular cartilage-related diseases, owing to its outstanding biocompatibility, high loading capability, and controlled release effect. The hybrid platform is effective for controlling symptoms of pain, inflammation and dysfunction, and cartilage repair and regeneration. In this review, we attempt to summarize recent studies on the latest development of micro-/nanoparticle hybrid hydrogel for the treatment of articular cartilage-related diseases. Furthermore, some prospects are proposed, aiming to improve the properties of the micro-/nanoparticle hybrid hydrogel platform so as to offer useful new ideas for the effective and accurate treatment of articular cartilage-related diseases.

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Safe Nanoparticles: Are We There Yet?

Cited by 322 publications

References 179 publications

A Novel Approach against Salmonella: A Review of Polymeric Nanoparticle Vaccines for Broilers and Layers

A Novel Approach against Salmonella: A Review of Polymeric Nanoparticle Vaccines for Broilers and Layers

Impact of Microplastics and Nanoplastics on Human Health

Effect of Micro-/Nanoparticle Hybrid Hydrogel Platform on the Treatment of Articular Cartilage-Related Diseases

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