Safety and antiulcer efficacy studies of Achillea millefolium L. after chronic treatment in Wistar rats

Cavalcanti, Ana Maria Salustiano; Baggio, Cristiane Hatsuko; Freitas, Cristina Setim; Rieck, Lia; Sousa, Renato Silva de; Silva-Santos, José Eduardo da; Mesía-Vela, Sonia; Marques, Maria Consuelo Andrade

doi:10.1016/j.jep.2006.03.011

Cited by 105 publications

(74 citation statements)

References 23 publications

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“…It is widely used in folk medicine (Wichtl, 1997). In Europe, it has been used as a remedy to treat digestive problems, diabetes, hepatobiliary diseases, amenorrhea, and also consumed for its antitumor and anti-inflammatory properties (Baretta et al, 2012;Cavalcanti et al, 2006;Jonsdottir, Omarsdottird, Vikingssona, Hardardottirc, Freysdottir, 2011). In addition, antimicrobial and antioxidant properties of yarrow have also been reported (Candan et al, 2003;Potrich et al, 2010;Trumbeckaite et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

Encapsulation of yarrow essential oil in hydroxypropyl-beta-cyclodextrin: physiochemical characterization and evaluation of bio-efficacies

Rakmai

Cheirsilp

Agrasar

et al. 2017

CyTA - Journal of Food

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Essential oil from yarrow (Achillea millefolium L. s. l.) has a broad spectrum of pharmacological activities. However, active chemical components of yarrow oil are sensitive to environmental factors such as, light, oxygen and temperature. Encapsulation of essential oil offers solutions for the limitation. Yarrow oil was encapsulated in hydroxypropyl-β-cyclodextrin (HPβCD) through freezedrying technique with encapsulation efficiency of 45%. Inclusion complex formation was examined by scanning electron microscope, Fourier transformed infrared spectroscopy and UV-vis analysis and phase solubility study. Yarrow oil gave strong antioxidant activity of 72% DPPH scavenging at 50 μg/mL. HPβCD could protect active compounds of essential oil and retained antioxidant activity after sunlight exposure. Yarrow oil also exhibited antibacterial activity against Staphylococcus aureus and Escherichia coli with the minimum inhibitory concentration (MIC) values of 250 μg/mL and 500 μg/mL, respectively. The antibacterial efficacy was much improved after encapsulation against both S. aureus and E. coli with the MIC value of 62.5 μg/mL.Encapsulación de aceite esencial de milenrama en hidroxipropil-beta-ciclodextrina. Caracterización fisicoquímica y evaluación de bioeficiencia. RESUMENEl aceite esencial de la milenrama (Achillea millefolium L. s. l.) presenta un amplio espectro de actividades farmacológicas. Sin embargo, los componentes químicos activos del aceite son sensibles a factores ambientales tales como, luz, oxígeno y temperatura. La encapsulación del aceite esencial ofrece soluciones para esta limitación. El aceite se encapsuló en hidroxipropil-β-ciclodextrina (HPβCD) mediante la técnica de liofilización con un rendimiento del 45%. La formación del complejo de inclusión se analizó mediante técnicas de SEM, FT-IR y UV-vis y se realizó un estudio de solubilidad. El aceite presentó una fuerte actividad antioxidante de 72% de DPPH. HPβCD protege los compuestos activos de aceite esencial y retoene la actividad antioxidante después de la exposición a luz solar. El aceite también exhibió actividad antibacteriana contra Staphylococcus aureus y Escherichia coli con valores mínimos de concentración inhibitoria (MIC) de 250 μg/mL y 500 μg/mL, respectivamente. La eficacia antibacteriana mejoró mucho después de la encapsulación contra S. aureus y E. coli con un valor de CIM de 62,5 μg /ml. ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

Encapsulation of yarrow essential oil in hydroxypropyl-beta-cyclodextrin: physiochemical characterization and evaluation of bio-efficacies

Rakmai

Cheirsilp

Agrasar

et al. 2017

CyTA - Journal of Food

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“…It is one of the most frequently used plant drug in Serbia (Tucakov, 1984). Upper parts of the plant collected during the blooming are recognized as an anti-inflammatory, antinociceptive, spasmolytic, antimicrobial and holagog drug (Nadim et al, 2011;Cavalcanti et al, 2006;Benedek et al, 2008;Ali et al, 2017). Yarrow preparations in the form of infusions, decoctions or fresh juices have been applied against various indications such as anorexia, stomach cramps, flatulence, gastritis, enteritis, internal and external bleeding (Willuhn, 2002;Wichtl, 2004).…”

Section: Introductionmentioning

confidence: 99%

Screening of yarrow (Achillea millefolium Agg.) populations in Serbia for yield components and essential oil composition

2017

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“…Acute treatment of rats with A. millefolium aqueous extract up to 10 g/kg orally and up to 3 g/kg intraperitoneally caused no death [13]. In addition, long-term studies demonstrated little side effects or toxicities in animals treated with A. millefolium extract [13]. In a study on the pregnant female rats, animals treated with the ethanol extracts of A. millefolium at a dose of 2.8 g/kg/day for one week, no signs of maternal toxicity were reported [14].…”

Section: Data Are Expressed As Mean ± Sem; T2 Results Were Obtained 2mentioning

confidence: 91%

Section: Data Are Expressed As Mean ± Sem; T2 Results Were Obtained 2mentioning

confidence: 99%

Achillea millefolium Aqueous Extract does not Impair Recognition Memory in Mice

Ayoobi¹,

Roohbakhsh²,

Allahtavakoli³

et al. 2013

Trop. J. Pharm Res

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Safety and antiulcer efficacy studies of Achillea millefolium L. after chronic treatment in Wistar rats

Cited by 105 publications

References 23 publications

Encapsulation of yarrow essential oil in hydroxypropyl-beta-cyclodextrin: physiochemical characterization and evaluation of bio-efficacies

Encapsulation of yarrow essential oil in hydroxypropyl-beta-cyclodextrin: physiochemical characterization and evaluation of bio-efficacies

Screening of yarrow (Achillea millefolium Agg.) populations in Serbia for yield components and essential oil composition

Achillea millefolium Aqueous Extract does not Impair Recognition Memory in Mice

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