Safety and cost effectiveness of pediatric percutaneous renal biopsy

Chesney, David S.; Brouhard, Ben H.; Cunningham, Robert J.

doi:10.1007/s004670050146

Cited by 36 publications

(48 citation statements)

References 4 publications

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“…The complication rates in different series may be as low as 2.6% or as high as 43% (9)(10)(11)(12)(13)(14)(15). In our biopsy series, the success and complication rates did not differ from most of the studies on children.…”

Section: Discussionmentioning

confidence: 49%

Assessment of Ten-Year-Long Results of Kidney Biopsies Performed on Children in the Thrace Region of Turkey

Özkayın¹,

Çıplak²,

Usta³

et al. 2016

Balkan Med J

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School of Medicine were assessed retrospectively. Results: A total of 100 patients were examined. Their mean age was 9.62±4.26 years (range: 1-17 years); 54% of the patients were girls and 46% were boys. The most frequent indication for kidney biopsy was nephrotic syndrome (33%). The most common kidney disease was primary glomerulonephritis, which was observed in 65% of cases. IgA nephropathy (24%) was the most frequently observed subtype in primary glomerulonephritis groups. Secondary glomerulonephritis was diagnosed in 35% of cases. Systemic lupus erythematosus (51%) was the most frequently observed subtype in the secondary glomerulonephritis groups. Conclusion: IgA nephropathy and systemic lupus erythematosus were the most frequent primary and secondary glomerulonephritis in our region among children, respectively.

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Section: Discussionmentioning

confidence: 49%

Assessment of Ten-Year-Long Results of Kidney Biopsies Performed on Children in the Thrace Region of Turkey

Özkayın¹,

Çıplak²,

Usta³

et al. 2016

Balkan Med J

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“…The number of complications reported in children following renal biopsy varied between 0-30% for major complications [13][14][15]. In some studies, macroscopic hematuria (4.5%) was the most frequent complication for native and transplant kidney.…”

Section: Discussionmentioning

confidence: 99%

Results of native and transplant kidney biopsies of children in a single center over a 15 years period

et al. 2017

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Renal biopsy is an important diagnostic procedure in pediatric nephrology. This study retrospectively investigates the indications, results and complications in a single tertiary children's hospital in Turkey. We evaluated the native and transplant kidney biopsies in Gazi University Pediatric Nephrology Department between 2001 and 2015. A total of 196 biopsies (144 natives and 52 transplants) were included into the study. The mean age of the patients was respectively 10.8 ± 3.5, 13.9 ± 1.5 years. The main indication for a biopsy was non-nephrotic proteinuria with or without hematuria (n¼ 35), followed by steroid-resistance nephrotic syndrome (SRNS) (n ¼ 34) and Henoch-Sch€ onlein purpura (HSP)-related proteinuria (n ¼ 20) for native kidneys. We found that focal segmental glomerulosclerosis (FSGS) (11.7%) was the most common histopathologic diagnosis for native kidneys, but acute cellular rejection (7.6%) was the most common histopathologic diagnosis for transplant kidneys. The complication rate in our study was founded 6.6% totally. Different complication rates were found in other studies; however, we think that this difference comes from the inspecting methodology of the complications. Hence, we wanted to share our own experience in the context of other studies in the literature. ARTICLE HISTORY

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“…Payors must develop adequate compensation mechanisms in order to encourage more patient focused ambulatory care. The cost effectiveness of ambulatory care has been documented among other disease models [18][19][20][21]. A randomized study published in 1988 of inpatient versus outpatient continuous infusion chemotherapy for adult patients with locally advanced head and neck cancer demonstrated the cost-effectiveness of outpatient chemotherapy [21].…”

Section: Discussionmentioning

confidence: 99%

Ambulatory high‐dose methotrexate administration among pediatric osteosarcoma patients in an urban, underserved setting is feasible, safe, and cost‐effective

Mahadeo

Santizo

Baker

et al. 2010

Pediatric Blood & Cancer

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Background. We describe the safety, feasibility, and provide a cost-estimate of outpatient high-dose methotrexate administration (HDMTX) among an urban, underserved population. Procedure. A retrospective analysis of ambulatory HDMTX administration among osteosarcoma patients, at Montefiore Medical Center's Children's Hospital (Bronx, NY) was performed. HDMTX (12 g/m 2 ) was given intravenously (IV) over 4 hr after urine alkalinization. Patients were discharged home to continue IV hydration and alkalinization delivered via a home infusion pump. Families were instructed to monitor urine pH overnight and management was adjusted according to our institution's treatment algorithm until MTX level ≤0.1 mol/L. A cost estimate was performed to assess the difference in costs for outpatient versus hypothetical inpatient administrations. Results. Of the 97 ambulatory HDMTX administrations, 99% were successfully completed. One patient failed outpatient administration secondary to home infusion pump malfunction. This patient successfully completed subsequent courses as an outpatient. Most patients (72%) had a MTX level of <10 mol/L at 24 hr post-HDMTX. No patients were found to have a MTX level of >50 mol/L at 24 hr. About 26% of courses were associated with grade III or IV neutropenia, 4% were associated with grade III or IV thrombocytopenia and 1% were associated with grade III/IV leukopenia. Compared to a hypothetical hospital inpatient stay, the hospital costs for ambulatory HDMTX were an average of $1400 less per cycle. Conclusion. Ambulatory HDMTX administration among an underserved, urban population is safe, feasible, and cost-effective. Pediatr Blood Cancer.

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Safety and cost effectiveness of pediatric percutaneous renal biopsy

Cited by 36 publications

References 4 publications

Assessment of Ten-Year-Long Results of Kidney Biopsies Performed on Children in the Thrace Region of Turkey

Assessment of Ten-Year-Long Results of Kidney Biopsies Performed on Children in the Thrace Region of Turkey

Results of native and transplant kidney biopsies of children in a single center over a 15 years period

Ambulatory high‐dose methotrexate administration among pediatric osteosarcoma patients in an urban, underserved setting is feasible, safe, and cost‐effective

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