Safety and Effectiveness of Analgesia with Remifentanil for Percutaneous Transhepatic Biliary Drainage

Park, Nam Sun; Bae, Jae-Ik; Park, Auh Whan; Won, Jong Uk; Lee, Hyun Seok

doi:10.2214/ajr.08.1755

Cited by 11 publications

(5 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nowadays, intravenous anesthesia is commonly used in our hospital, such as remifentanil combined with sedative drugs (5). Remifentanil has a strong analgesic effect, fast onset, and short half-life (26)(27)(28). However, the extensive use of remifentanil in a short time may cause respiratory depression (6)(7)(8) and may cause a post-surgical hyperalgesia (29,30).…”

Section: Discussionmentioning

confidence: 99%

The use of Esketamine in CT-guided percutaneous liver tumor ablation reduces the consumption of remifentanil: a randomized, controlled, double-blind trial

Su¹,

Zhang²,

Wang³

et al. 2022

Ann Transl Med

View full text Add to dashboard Cite

Background: In the anesthesia management of percutaneous liver tumor ablation, the requirement of analgesia is very strict. Currently, intravenous anesthesia is commonly used, such as remifentanil combined with sedative drugs. However, the pain relief is not instantaneous after increasing the dosage of remifentanil.Esketamine, a medium-or long-term analgesic drug, does not inhibit respiration to maintain patient comfort during the ablation and reduces the consumption of remifentanil. Therefore, this experiment was designed to investigate the potential of combinational therapy and the most appropriate dose of esketamine.Methods: A total of 120 patients were randomly divided into three groups by SPSS. The regular anesthesia model included dexmedetomidine 0.5 μg/kg, intravenous glucose tolerance test, remifentanil continuous infusion, flurbiprofen 50 mg, i.v., palonosetron 0.225 mg, i.v., and 1% lidocaine for local anesthesia. Group A was the regular control group, only using the regular model; Group B also received with 0.1 mg/kg esketamine, i.v.; and Group C also received 0.2 mg/kg esketamine, i.v.. The whole experiment was doubleblind.

show abstract

Section: Discussionmentioning

confidence: 99%

The use of Esketamine in CT-guided percutaneous liver tumor ablation reduces the consumption of remifentanil: a randomized, controlled, double-blind trial

Su¹,

Zhang²,

Wang³

et al. 2022

Ann Transl Med

View full text Add to dashboard Cite

show abstract

“…Context-sensitive half-life time is approximately 4 min after the infusion is stopped [6,7]. Remifentanil has been reported to be a suitable option for analgesia during painful interventional radiology procedures, in particular during PTBD [11]. However, despite an increased risk in depressed respiration, longacting opioids are preferable if prolonged pain is expected during postoperative observation.…”

Section: Discussionmentioning

confidence: 99%

“…The ideal drug accomplishes rapid onset, with short-time action, low side effects, and immediate reversibility, because the measures during PTBD may provoke intense pain sensations of very short duration, such as peritoneal transgressions or balloon dilatation procedures. Remifentanil, a potent opioid with rapid onset and short duration of action, has been reported to be safe and effective during PTBD [10,11]. Elimination by nonspecific plasma esterases does not depend on hepatic and renal functions [12].…”

Section: Introductionmentioning

confidence: 99%

Procedural sedation and analgesia for percutaneous trans-hepatic biliary drainage: Randomized clinical trial for comparison of two different concepts

et al. 2020

View full text Add to dashboard Cite

Procedural sedation and analgesia (PSA) is important during painful dilatation and stenting in patients undergoing percutaneous trans-hepatic biliary drainage (PTBD). A prospective, nonblinded randomized clinical trial was performed comparing different analgesic regimens with regard to the patient’s comfort. Patients were randomly assigned to two treatment groups in a parallel study, receiving either remifentanil or combined midazolam, piritramide, and S-ketamine. The primary study endpoint was pain intensity before, during, and after the intervention using the numerical rating scale (0, no pain; 10, maximum pain). The secondary study endpoint was the satisfaction of the interventional radiologist. Fifty patients underwent PTBD of whom 19 (38.0%) underwent additional stenting. During intervention, the two groups did not differ significantly. After the intervention, the need for auxiliary opioids was higher (12.5% vs 7.7%; p = 0.571) and nausea/vomiting was more frequently observed (33.4% vs 3.8%; p = 0.007) in patients with remifentanil than in patients with PSA. Overall, 45 patients (90.0%) needed additional administration of non-opioid analgesics during postinterventional observation. Remifentanil and combined midazolam, piritramide, and S-ketamine obtained adequate analgesic effects during PTBD. After the intervention, medications with antiemetics and long-acting analgesics were more frequently administered in patients treated with remifentanil (EudraCT No. 2006-003285-34; institutional funding).

show abstract

“…7 Park ve ark., ağrılı girişimsel radyolojik uygulamalardan, lokal anestezi altında perkütan transhepatik biliyer drenajda 0,1 µg/kg/dk remifentanil infüzyonu (maximum 0,15 µg/kg/dk) uygulamışlar, hastaların ortalama sedasyon skorlarını 2,39 olarak gözlemlemişlerdir. 17 Bir hastada beş düzeyinde sedasyon oluşur iken; hiçbir hastada altı düzeyinde sedasyon oluşmamıştır. Sonuç olarak, remifentanil infüzyonunun uygun bir seçenek olduğu vurgulanmıştır.…”

Section: Gereç Ve Yöntemlerunclassified

Our Sedation and Anaesthesia Experiences at the Interventional Radiology Unit

Balkan¹,

Tülübaş²,

Balan³

et al. 2018

J Reconstr Urol

View full text Add to dashboard Cite

show abstract

Safety and Effectiveness of Analgesia with Remifentanil for Percutaneous Transhepatic Biliary Drainage

Cited by 11 publications

References 26 publications

The use of Esketamine in CT-guided percutaneous liver tumor ablation reduces the consumption of remifentanil: a randomized, controlled, double-blind trial

The use of Esketamine in CT-guided percutaneous liver tumor ablation reduces the consumption of remifentanil: a randomized, controlled, double-blind trial

Procedural sedation and analgesia for percutaneous trans-hepatic biliary drainage: Randomized clinical trial for comparison of two different concepts

Our Sedation and Anaesthesia Experiences at the Interventional Radiology Unit

Contact Info

Product

Resources

About