2021
DOI: 10.1186/s13643-021-01758-7
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Safety and efficacy of different antibiotic regimens in patients with ocular toxoplasmosis: systematic review and meta-analysis

Abstract: Background Ocular toxoplasmosis (OT) is the most common cause of posterior uveitis, which leads to visual impairment in a large proportion of patients. Antibiotics and corticosteroids lower the risk of permanent visual loss by controlling infection and inflammation. However, there remains disagreement regarding optimal antibiotic therapy for OT. Therefore, this systematic review and meta-analysis were performed to determine the effects and safety of existing antibiotic treatment regimens for OT… Show more

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Cited by 17 publications
(12 citation statements)
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“…A meta-analysis by Zhang et al evaluated the most effective therapy for ocular toxoplasmosis in immunocompetent patients 65 . Another systematic review and meta-analysis by Feliciano-Alfonso et al examined the effects and safety of existing drug regimens in treating ocular toxoplasmosis 77 . However, to date, no systematic reviews or meta-analyses have evaluated the effectiveness of intravitreal drug administration for treating ocular toxoplasmosis.…”
Section: Discussionmentioning
confidence: 99%
“…A meta-analysis by Zhang et al evaluated the most effective therapy for ocular toxoplasmosis in immunocompetent patients 65 . Another systematic review and meta-analysis by Feliciano-Alfonso et al examined the effects and safety of existing drug regimens in treating ocular toxoplasmosis 77 . However, to date, no systematic reviews or meta-analyses have evaluated the effectiveness of intravitreal drug administration for treating ocular toxoplasmosis.…”
Section: Discussionmentioning
confidence: 99%
“…Warum das so ist, lässt sich nur spekulieren. Sicherlich spielen aber nach wie vor der fehlende Nachweis der Antibiotikawirkung auf die funktionellen Endergebnisse und die Kenntnis der Verträglichkeit und der Nebenwirkungen eine entscheidende Rolle [5,7]. Andererseits sehen wir einen klaren Trend in Richtung einer zunehmenden Akzeptanz von TMP/SMZ.…”
Section: » Seit 2007 Hat Eine Deutlicheunclassified
“…Es wird immer wieder berichtet, dass einzelne Patienten auf die primär verord- nete Therapie nicht adäquat ansprechen [3,5,7] Nur in Ausnahmefällen wird die intravitreale Injektion als therapeutische Option erwogen [16]. Dies ist in Anbetracht der Pathophysiologie der Erkrankung sinnvoll und steht in Einklang mit vergleichbaren Erhebungen, die dies als selektives Verfahren ansehen [3,21].…”
Section: » Seit 2007 Hat Eine Deutlicheunclassified
“…Ocular toxoplasmosis represents the leading cause of posterior uveitis worldwide, 1 with the highest incidence reported in Brazil was 20%. 2 In immunocompetent individuals, ocular toxoplasmosis is responsible for 30–50% of all cases of posterior uveitis.…”
Section: Introductionmentioning
confidence: 99%