Safety and efficacy of larval therapy on treating leg ulcers: a protocol for systematic review and meta-analysis

Abstract

IntroductionLeg ulcers (LUs) not only seriously affect life and work of patients, but also bring huge economic burden to the society. As a potential underused biological debridement, larval therapy provides help for the treatment of LUs. The purpose of our research is to assess whether patients with LUs can benefit from larval therapy.Methods and analysisThe following electronic databases will be searched: PubMed, EMBASE, Web of Science, the Cochrane Library, China National Knowledge Infrastructure Database, Wanfang Database and Chinese Biological Medicine. Randomised controlled trials are eligible for inclusion. There will be no restrictions with respect to language and search date is up to June 2020. Primary outcomes investigated are complete healing rate after treatment, time to ulcer healing, reduction of wound surface area and adverse events. Risk ratios will be used for categorical data; weighted mean difference will be used for measurement data. Subgroup analysis and sensitivity analysis will be considered if heterogeneity exists. The results of data synthesis will be performed by narrative summary and quantitative analysis.Ethics and disseminationThis systematic review does not require the approval of the ethics committee because individual data on patients are not collected. The results of the study will be disseminated in peer-reviewed journals.PROSPERO registration numberCRD42020176953.

16. Packaging Technology

“…To that end, researchers planning such studies are encouraged to consider the recommendations on clinical data collection, prepared by the European Wound Management Association's Patient Outcome Group [122], that describe criteria for producing rigorous outcomes in both RCTs and clinical studies, and describe how to ensure studies are consistent and reproducible. Another helpful read is a protocol proposed by Fan and colleagues [123] on how to conduct a systematic review and meta-analysis, which draws attention to particularly topical issues, such as the choice of participants for a given clinical trial (the inclusion of very heterogeneous wounds has been common) and poorly standardised practice in relation to the use of maggot therapy. For example, there may be significant differences in the effect of debridement with variations only in these two parameters.…”

Preclinical study of diabetic foot ulcers: From pathogenesis to vivo/vitro models and clinical therapeutic transformation

“…According to the aetiology, DFU can be broadly classified into three categories: ischemic DFU, infectious DFU and neurological DFU. Currently, DFU treatment includes debridement, anti‐infection, revascularization and hyperbaric oxygen 7,8 . Altho ugh the above treatments can promote angiogenesis, improve neurological function or reduce inflammatory response to promote DFU healing, but can not prevent recurrent DFU, or even lead to amputation.…”

“…Currently, DFU treatment includes debridement, anti-infection, revascularization and hyperbaric oxygen. 7,8 Altho ugh the above treatments can promote angiogenesis, improve neurological function or reduce inflammatory response to promote DFU healing, but can not prevent recurrent DFU, or even lead to amputation. With the rise of new technologies such as metabonomics, proteomics and single cell sequencing, the new regimen of DFU therapy is gradually being recognized.…”

Venous Leg Ulcers: Advanced Therapies and New Technologies

“…Debridement as the elimination of necrotic tissue from the area of a wound can reduce the healing time period. There are diverse methods of debridement, such as mechanical or enzymatic removal [ 15 , 17 ]. After debridement, other therapeutic methods can be applied, including skin transplants, in order to achieve wound closure [ 18 ].…”