Safety and efficacy of microorganism DSM 11798 as a technological additive for all avian species

Abstract

Biomin® BBSH 797 is the trade name for a feed additive containing viable cells of an unnamed bacterium (DSM 11798). The EFSA Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) produced an opinion on the safety and efficacy of this additive when used with pigs concluding that the additive itself did not raise any safety concern. It was confirmed that the additive could reduce the trichothecene, deoxynivalenol (DON), producing the less toxic de-epoxy metabolite. The applicant is now seeking authorisation for the use of the additive in feed for all avian species and, since the current authorisation only covers DON, the amending of this authorisation to include all trichothecene mycotoxins. Chickens and turkeys for fattening and laying hens showed no adverse effects when the additive was added to diets at 1000 times the recommended dose. Consequently, the additive is considered safe for these species/categories when used at the recommended dose of 1.7 9 10 8 colony-forming units (CFU)/kg complete feed. This conclusion is extended to all avian species. The use of the additive in feed for all avian species is not expected to introduce concerns for consumers, users or the environment not previously considered. In vitro and in vivo studies showed that the inclusion of the additive at the recommended dose of 1.7 9 10 8 CFU/kg was effective in reducing contaminating DON in feed when given to avian species with a concomitant production of the less toxic de-epoxy metabolite. The additive was shown to reduce the 12,13-epoxide group of representative trichothecenes. It would be reasonable to assume a similar reaction with other mycotoxins of the same structural type independent of the animal species or category receiving contaminated feed. The additive is compatible with the coccidiostats monensin sodium, salinomycin sodium, narasin, narasin/nicarbazin, nicarbazin, robenidine hydrochloride and diclazuril.

Possibilities for the Biological Control of Mycotoxins in Food and Feed

“…It was the first microorganism applied as a mycotoxin deactivating additive in feed. Regarding the microorganism DSM 11798 Genus nov. species nov. (BBSH 797) product, EFSA (European Food Safety Authority) delivered a positive opinion on its safety for the target animals (pigs and avian species), consumer, user and the environment, when used under the proposed conditions [ 47 , 48 ]. The appropriate implementing regulations were established in 2016 and 2017 [ 49 , 50 ].…”

Deoxynivalenol: Masked forms, fate during food processing, and potential biological remedies

“…Commercial products, such as Biomin ® BBSH 797 containing biotransform agents, have also been developed and patented as feed additives (EFSA, 2005). Biomin ® BBSH 797 is the first microorganism authorized by the European Food Safety Authority that converts trichothecenes into less toxic metabolites for poultry and swine diets (Rychen et al., 2017). This microorganism can convert DON into DOM‐1.…”

Isolation of a potential probiotic strain Bacillus amyloliquefaciensLPB‐18 and identification of antimicrobial compounds responsible for inhibition of food‐borne pathogens

“…Farzaneh et al obtained a promising A. flavus R5 antagonist strain B. subtilis UTBSP1, which can reduce the growth of A. flavus R5 and aflatoxins accumulation(Farzaneh et al, 2016).Additives et al displayed the strain Eubacterium BBSH 797, isolated from bovine rumen fluid, can transform the deoxynivalenol (DON) to nontoxic metabolite trichothecenes due to its epoxidase(Additives et al, 2017). Li et al found that B. velezensis from the surface of a healthy race significantly controls A. flavus contamination(Li et al 2022).…”