Safety and efficacy of policosanol in patients with high on‐treatment platelet reactivity after drug‐eluting stent implantation: two‐year follow‐up results

Xu, Kai; Liu, Xinming; Li, Yang; Wang, Yunuo; Zang, Hongyun; Guo, Liang; Wang, Yuan; Zhao, Wei; Wang, Xiaozeng; Han, Yaling

doi:10.1111/1755-5922.12204

Cited by 12 publications

(10 citation statements)

References 39 publications

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“…Native reconstituted HDL also displayed insulin secretion activity along with a wound-healing effect. Many studies on patients have reported that policosanol has efficacy in the treatment of hyperlipidemia, diabetes, and hypertension [ 34 , 35 ], although the detailed molecular mechanism has not been elucidated. As there has been almost no study on the effects of policosanol on healthy subjects with hyperlipidemia and hypertension, this study investigated the efficacy of policosanol in ordinary and healthy subjects with prehypertension.…”

Section: Discussionmentioning

confidence: 99%

Consumption of Cuban Policosanol Improves Blood Pressure and Lipid Profile via Enhancement of HDL Functionality in Healthy Women Subjects: Randomized, Double‐Blinded, and Placebo‐Controlled Study

Cho

Kim

Yadav

et al. 2018

Oxidative Medicine and Cellular Longevity

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Policosanol has been reported to improve blood pressure, lipid profile, and HDL functionality via inhibition of cholesteryl ester transfer protein (CETP) both in vitro and in vivo in zebrafish and human models. However, there are limited reports and randomized, double-blinded trials on policosanol that could advocate the blood pressure-lowering effect in prehypertensive participants. Therefore, we performed in vitro, in vivo, and ex vivo experiments to provide more substantial and concrete data on the blood pressure-lowering effect of policosanol. Consumption of policosanol for 8 weeks enhanced plasma antioxidant activity. In the policosanol group, plasma total cholesterol (TC) and triglyceride (TG) levels were reduced up to 20% and 14%, respectively, and HDL-C level was elevated up to 1.3-fold compared to that at week 0. TG/HDL-C and cholesteryl ester transfer protein (CETP) activities were reduced up to 36% and 20%, respectively. Uptake of oxidized LDL in macrophages was reduced as oxidized species levels were reduced, and HDL2-associated paraoxonase activities were enhanced by 60% compared to those at week 0. Encapsulation of policosanol into reconstituted HDL (PCO-rHDL) enhanced cholesterol efflux activity and insulin secretion capacity. In conclusion, consumption of policosanol for 8 weeks in healthy female subjects resulted in lowered blood pressure and CETP activity via elevation of HDL/apoA-I contents and enhancement of HDL functionalities, including cholesterol efflux and insulin secretion. These functional enhancements of HDL can contribute to the prevention of aging-related diseases, hypertension, and stroke.

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Section: Discussionmentioning

confidence: 99%

Consumption of Cuban Policosanol Improves Blood Pressure and Lipid Profile via Enhancement of HDL Functionality in Healthy Women Subjects: Randomized, Double‐Blinded, and Placebo‐Controlled Study

Cho

Kim

Yadav

et al. 2018

Oxidative Medicine and Cellular Longevity

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“…Another study that assessed the safety and effects of adding polycosanol for patients receiving antiplatelets after drug eluting stent insertions found that adding polycosanol did not significantly elevate cardiovascular events, deaths, or bleeding tendencies (LOE of 1–) [155]. However, findings on the association of polycosanol and improvements in dyslipidemia are inconsistent [156], and there have been no clinical trials on the long-term clinical outcomes or secondary prevention outcomes related to polycosanol intake in patients with CAD.…”

Section: Exercise Therapy For Cardiac Rehabilitationmentioning

confidence: 99%

Clinical Practice Guideline for Cardiac Rehabilitation in Korea

et al. 2019

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Objective Though clinical practice guidelines (CPGs) for cardiac rehabilitation (CR) are an effective and widely used treatment method worldwide, they are as yet not widely accepted in Korea. Given that cardiovascular disease is the second leading cause of death in Korea, it is urgent that CR programs be developed. In 2008, the Government of Korea implemented CR programs at 11 university hospitals as part of its Regional Cardio-Cerebrovascular Center Project, and three additional medical facilities will be added in 2019. In addition, owing to the promotion of CR nationwide and the introduction of CR insurance benefits, 40 medical institutions nationwide have begun CR programs even as a growing number of medical institutions are preparing to offer CR. The purpose of this research was to develop evidence-based CPGs to support CR implementation in Korea. Methods This study is based on an analysis of CPGs elsewhere in the world, an extensive literature search, a systematic analysis of multiple randomized control trials, and a CPG management, development, and assessment committee comprised of 33 authors—primarily rehabilitation specialists, cardiologists, and thoracic surgeons in 21 university hospitals and two general hospitals. Twelve consultants, primarily rehabilitation, sports medicine, and preventive medicine specialists, CPG experts, nurses, physical therapists, clinical nutritionists, and library and information experts participated in the research and development of these CPGs. After the draft guidelines were developed, three rounds of public hearings were held with staff members from relevant academic societies and stakeholders, after which the guidelines were further reviewed and modified. Principal Conclusions CR involves a more cost-effective use of healthcare resources relative to that of general treatments, and the exercise component of CR lowers cardiovascular mortality and readmission rates, regardless of the type of coronary heart disease and type and setting of CR. Individualized CR programs should be considered together with various factors, including differences in heart function and lifestyle, and doing so will boost participation and adherence with the CR program, ultimately meeting the final goals of the program, namely reducing the recurrence of myocardial infarction and mortality rates.

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“…Numerous clinical trials found that DAPT could reduce the higher risk of major adverse cardiovascular events in CAD patients. However, there are still some CAD patients suffering from thrombotic events, which might be related to HPR …”

Section: Introductionmentioning

confidence: 99%

“…Besides of that, about 40% of clopidogrel‐treated patients displayed a high on‐treatment platelet reactivity (HPR) . Platelet activation and aggregation were the pathophysiological basis of various atherosclerotic thrombosis and coronary stent thrombosis, which might induce the recurrence of ischemic cardiovascular adverse events. Numerous clinical trials found that DAPT could reduce the higher risk of major adverse cardiovascular events in CAD patients.…”

Section: Introductionmentioning

confidence: 99%

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CYP2C19 and ABCB1 genetic polymorphisms correlate with the recurrence of ischemic cardiovascular adverse events after clopidogrel treatment

Hou

Han

Gan

et al. 2018

Clinical Laboratory Analysis

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Safety and efficacy of policosanol in patients with high on‐treatment platelet reactivity after drug‐eluting stent implantation: two‐year follow‐up results

Abstract: Policosanol reduced platelet reactivity to a similar extent as high maintenance dose of clopidogrel without increasing bleeding rate.

Cited by 12 publications

References 39 publications

Consumption of Cuban Policosanol Improves Blood Pressure and Lipid Profile via Enhancement of HDL Functionality in Healthy Women Subjects: Randomized, Double‐Blinded, and Placebo‐Controlled Study

Consumption of Cuban Policosanol Improves Blood Pressure and Lipid Profile via Enhancement of HDL Functionality in Healthy Women Subjects: Randomized, Double‐Blinded, and Placebo‐Controlled Study

Clinical Practice Guideline for Cardiac Rehabilitation in Korea

CYP2C19 and ABCB1 genetic polymorphisms correlate with the recurrence of ischemic cardiovascular adverse events after clopidogrel treatment

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