Safety and Efficacy of Rifaximin in Prophylaxis of Spontaneous Bacterial Peritonitis: A Systematic Review and Meta-analysis

Menshawy, Amr; Mattar, Omar Mohamed; Barssoum, Kirolos; AboEl-Naga, Ammar M; Salim, Haitham Mohamed; Mohamed, Ahmed; Elgebaly, Ahmed

doi:10.2174/1389450119666180924145156

Cited by 17 publications

(15 citation statements)

References 15 publications

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“…As for ascetic fluid-total protein levels, this is consistent with Nabiel et al, [8] and Paul et al [10] who have reported that ascitic fluid opsonic activity closely correlates with fluid protein concentration; fluids < 1.0 g/dl of protein have reported decreasing opsonic activity and thus highly susceptible to protein concentrations With respect to the amount of ascetic fluid albumin in SBP patients, this was agreed with Paul et al [10], which may be explained by the decreased functional activity of hepatocytes and innate immune system fatigue creating what was referred to as immune dysfunction related cirrhosis [11].…”

Section: Discussionsupporting

confidence: 81%

Study of Ascitic Fluid Micro RNA-155 in Patients with Spontaneous Bacterial Peritonitis

Alsalam

El-Toukhy

Mohamed

et al. 2021

Benha Journal of Applied Sciences

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Background: In patients with cirrhosis, spontaneous bacterial peritonitis is the most common bacterial infection. This research aims at studying the ascititc fluid Micro RNA-155 as a possible biomarker in spontaneous peritonitis. Method: 187 liver cirrhosis and ascites were chosen, 97 SBP patients and 90 SBP patients, all patients had historical history, thorough and local examination, comprehensive investigations, abdominal ultrasonography, diagnostic abdominal paracentesis and Micro RNA-155 evaluation. Results: in SBP, the average value of TLC, Polymorphene, and RNA-155 was considerably greater than non SBP, but in the SBP group the average value of ascetic albumin, glucose, and protein was considerably lower than in the non-SBP group. For MiR-155, the optimal balance of sensitivity and specificity was 0.022 for ROC as a marker with sensitivity 60 percent and specificity 62.0 percent and surface area under curve 0.639. No statistically significant link exists among SBP patients among Micro RNA-155 with TLC, polymorphs, MELD score and Child Pugh score values. Conclusion; Although MiR-155 was increased in the ascetic fluid of SBP patients, and is a predictor for SBP development, it cannot be employed as diagnostic marker in the SBP, according to this research.

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Section: Discussionsupporting

confidence: 81%

Study of Ascitic Fluid Micro RNA-155 in Patients with Spontaneous Bacterial Peritonitis

Alsalam

El-Toukhy

Mohamed

et al. 2021

Benha Journal of Applied Sciences

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“…The procalcitonin level was significantly correlated with the (ascitic fluid) white blood cell count (rs=0.404, P<0.01) [20,37]. Cekin et al, reported higher procalcitonin serum levels in patients with positive bacterial culture in ascitic fluid compared to patients without culture positivity [21,38]. Finally, Abdel-Razik et al, demonstrated that at a cutoff value of 0.94 ng/mL, serum procalcitonin had 94.3% sensitivity and 91.8% specificity for detecting spontaneous bacterial peritonitis [39].…”

Section: Discussionmentioning

confidence: 99%

The Role of MicroRNAs (miRNA 155, miRNA-146b) and Procalcitonin as Novel Markers for the Diagnosis of Spontaneous Bacterial Peritonitis

El-Hassib¹,

Abo-Elmatty²,

Mesbah³

et al. 2021

TOBIOMJ

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Background: MircoRNAs are endogenous, small non-coding RNA molecules that have been recognized as important modulators of gene expression. MicroRNA is considered one of the potential biomarkers of infection and inflammation. Our study aims to identify the potential role of miRNA-155, miRNA-146b, and Procalcitonin (PCT) in the early detection of spontaneous bacterial peritonitis in cirrhotic liver patients. miRNA-155 and 146b are molecular biomarkers , while procalcitonin is a serum marker in ascites patients complicated with Spontaneous Bacterial Peritonitis (SBP) . Methods: This study was conducted on 199 patients, 101 of them have ascites complicated with spontaneous bacterial peritonitis, and 98 patients without spontaneous bacterial peritonitis (control group). Ascitic fluid samples were collected from patients with SBP undergoing paracentesis at National Hepatology Institute in Egypt. MicroRNAs were determined in the serum using qPCR (quantitative polymerase chain reaction), while procalcitonin has been assessed in serum samples using ELISA (Enzyme-linked immune assay) technique. Results: Serum levels of miRNA-146b & miRNA-155 were significantly higher (p<0.001) in spontaneous bacterial peritonitis patients (79.2% and 97.0% respectively) than ascites patients (17.3% and 7.1%, respectively). Furthermore, the serum level of procalcitonin was significantly higher (p<0.001) in spontaneous bacterial peritonitis patients than that in ascites patients (68.3% and 27.6%, respectively). Conclusion: miRNA-155, miRNA-146b and procalcitonin can be used as early markers for the detection of SBP in hepatic patients with ascites.

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“…In the inflammatory process, the synthesis of SAA is expected. Certainly, activated monocytes express and release SAA [ 30 , 31 ]. In spite of local SAA release, there is a serum contribution of SAA in the effusion due to a positive strong correlation between them [ 30 - 32 ].…”

Section: Discussionmentioning

confidence: 99%

Amyloid A in Serum and Ascitic Fluid as a Novel Diagnostic Marker of Spontaneous Bacterial Peritonitis

Badawi

Asghar

Elshweikh

et al. 2020

AIAAMC

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Background: Diagnosis of Spontaneous Bacterial Peritonitis (SBP) depends mainly on ascetic fluid culture which may be negative in spite of the clinical suggestion of SBP and high ascetic fluid neutrophilic count. Aim: This study aimed to evaluate the biological importance of amyloid A biomarker in both serum and ascetic fluid to diagnose SBP as early as possible and to compare it to other markers (C-reactive protein (CRP), and the neutrophil-to-lymphocyte ratio (NLR)). Methods: This study included 37 patients with hepatic ascites; twenty-two of them had SBP, and 15 patients did not have SBP. Serum and ascetic fluid amyloid A, ascetic fluid neutrophil, C-reactive protein, and neutrophil-to-lymphocyte ratio were measured in all subjects before the start of antimicrobial chemotherapy to the infected ones. Results: Both the serum and ascetic fluid amyloid and also, CRP were significantly higher in patients infected with ascetic fluid than others. The cut-off point of serum amyloid A for early detection of SBP was 9.25ug/ml with the high sensitivity and specificity. For ascetic amyloid A, the sensitivity and specificity were 90.09% and 60% at cut-off point 2.85ug/ml, Conclusion: Amyloid A in serum and ascitic fluid can be considered as a good biomarker for early diagnosis of SBP.

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Safety and Efficacy of Rifaximin in Prophylaxis of Spontaneous Bacterial Peritonitis: A Systematic Review and Meta-analysis

Cited by 17 publications

References 15 publications

Study of Ascitic Fluid Micro RNA-155 in Patients with Spontaneous Bacterial Peritonitis

Study of Ascitic Fluid Micro RNA-155 in Patients with Spontaneous Bacterial Peritonitis

The Role of MicroRNAs (miRNA 155, miRNA-146b) and Procalcitonin as Novel Markers for the Diagnosis of Spontaneous Bacterial Peritonitis

Amyloid A in Serum and Ascitic Fluid as a Novel Diagnostic Marker of Spontaneous Bacterial Peritonitis

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