Safety and efficacy of spinosad chewable tablets for treatment of flea infestations of cats

Paarlberg, Tandy; Wiseman, Scott; Trout, Candace M.; Kee, Elizabeth A.; Snyder, Daniel E.

doi:10.2460/javma.242.8.1092

Cited by 18 publications

(13 citation statements)

References 6 publications

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“…This clinical situation confirms the excellent efficacy and tolerance and the good palatability of spinosad tablets in cats [13, 14]. In the present study, no adverse event was observed, particularly no vomiting or diarrhea.…”

Section: Discussionsupporting

confidence: 88%

“…In the present study, no adverse event was observed, particularly no vomiting or diarrhea. Vomiting had been reported in 14% of the cats recruited in a large field trial [13]. Systemic treatment is well adapted to control fleas in animals with skin lesions.…”

Section: Discussionmentioning

confidence: 99%

“…Subsequently, it was approved for cats in USA, Canada, and Japan in 2012 and in the European Union in 2013. Its excellent efficacy against fleas and its rapid killing effect that are observed in dogs [9–12] are also reported in cats [13, 14]. …”

Section: Introductionmentioning

confidence: 99%

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Efficacy of Spinosad Tablets Administered to a Colony of 15 Indoor Cats Naturally Infested with Fleas

Cadiergues

Pressanti

2014

ISRN Veterinary Science

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The aims of the study were (i) to describe adult fleas distribution in a strictly indoor cat colony composed of cats with flea allergy dermatitis (FAD) and non-FAD cats and (ii) to evaluate the efficacy of spinosad used alone. Skin lesions were scored according to the SCORing Feline Allergic Dermatitis lesion severity scale (SCORFAD) on days 0, 15, 30, 45, 60, and 90. Cats were combed prior to the treatment (days 0, 30, and 60) and on days 15, 45, and 90; collected fleas were replaced on the animals. All cats received flavored spinosad tablets (Comfortis) at a dosage of 50–75 mg/kg on days 0, 30, and 60. Cats were fed immediately afterwards. On day 0, a total of 60 fleas were collected (mean: 4 ± 4). Cats with FAD had a SCORFAD of 6, 8, 12, and 13 and harbored 0, 2, 1, and 0 fleas, respectively. Tablets were taken voluntarily by 8, 11, and 12 cats on days 0, 30, and 60, respectively. No adverse event was recorded. From day 15 to day 90, no fleas could be collected. SCORFAD was reduced by 40%, 71%, 80%, 89%, and 98% on days 15, 30, 45, 60, and 90, respectively.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

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Efficacy of Spinosad Tablets Administered to a Colony of 15 Indoor Cats Naturally Infested with Fleas

Cadiergues

Pressanti

2014

ISRN Veterinary Science

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“…The efficacy of selamectin at the same time points was more variable: 88.8 and 97.7 per cent, with 29.4 and 64.7 per cent of cats flea free at the same time points, respectively. This variation may be due to geographical differences in flea strains and their susceptibility to selamectin or to the differences in flea burdens (Paarlberg and others 2013). …”

Section: Discussionmentioning

confidence: 99%

“…This paper summarises data gathered during the studies conducted to evaluate the use of oral spinosad (Comfortis chewable tablets for dogs and cats, Elanco Animal Health) for flea control in cats in Europe and supplements data from a US field study where efficacy and tolerance of spinosad in cats in the dose range 50–100 mg/kg were investigated (Paarlberg and others 2013). …”

Section: Introductionmentioning

confidence: 99%

Evaluation of spinosad for the oral treatment and control of flea infestations on cats in Europe

Franc

Bouhsira

Böhm

et al. 2013

Veterinary Record Open

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MethodsAn ectoparasiticide containing spinosad was evaluated as an oral formulation for cats. Two European laboratory studies and a European multicentre field efficacy and safety study assessed the use of a chewable tablet formulation of spinosad at a dose range of 50–75 mg/kg for treatment and control of flea infestations on cats.ResultsThe studies with experimentally infested cats consistently demonstrated persistent activity against Ctenocephalides felis with >98 per cent efficacy at four weeks post-treatment. In the field study with naturally infested client-owned cats from 18 clinics across Germany and Italy, two monthly doses of spinosad were administered; selamectin was the comparator product. Safety was evaluated in 226 cats, each receiving at least one dose of spinosad or selamectin; both products were well tolerated. 113 spinosad-treated cats and 71 selamectin-treated cats showed >97 per cent reductions in geometric mean flea counts within 14 days post-treatment and at 60 days post-treatment efficacy was >98 per cent in both groups. Analysis of success rates showed 96 per cent in spinosad-treated cats compared with 90.9 per cent in selamectin-treated cats at day 60. The spinosad tablets were successfully administered to over 98 percent of cats. These studies indicate that this formulation of spinosad is safe and efficacious for treatment and prevention of flea infestations in cats.

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Flea Biology, Allergy and Control

Noli¹

2020

Feline Dermatology

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Safety and efficacy of spinosad chewable tablets for treatment of flea infestations of cats

Abstract: Results of this study indicated spinosad and selamectin both reduced flea counts and FAD scores for cats, although spinosad was more effective. Monthly oral administration of spinosad may be practical for treatment of flea infestations and FAD in cats.

Cited by 18 publications

References 6 publications

Efficacy of Spinosad Tablets Administered to a Colony of 15 Indoor Cats Naturally Infested with Fleas

Efficacy of Spinosad Tablets Administered to a Colony of 15 Indoor Cats Naturally Infested with Fleas

Evaluation of spinosad for the oral treatment and control of flea infestations on cats in Europe

Flea Biology, Allergy and Control

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