Safety and Efficacy of Xenon in Routine Use as an Inhalational Anaesthetic

Le xénon ne réduit pas les besoins d’opioïdes en chirurgie orthopédique

“…20 D Di is sc cu us ss si io on n In a previous study xenon, compared to N 2 O, was associated with a reduction of fentanyl requirement by far exceeding the difference in MAC of the two gases. 1 In contrast, our data do not show a relevant reduction of alfentanil requirements to suppress hemodynamic, autonomic or motor responses to Cp 50 in xenon patients compared to those receiving a MAC-equivalent combination of N 2 O and desflurane. There was no difference in the alfentanil infusion rate and the mean measured alfentanil concentration during surgery even though the BIS level was lower in the xenon patients.…”

“…ORE than ten years ago Lachmann and co-workers detected a fivefold reduction of the fentanyl requirement for general surgery in patients anesthetized with 70% xenon compared to those anesthetized with 70% nitrous oxide (N 2 O) in oxygen. 1 These results triggered a number of subsequent studies documenting the fast induction and emergence kinetics 2 and the cardiovascular stability of xenon. 3,4 Xenon was also suggested as a potential alternative to N 2 O because it is not teratogenic.…”

Les anesthésiques volatiles et l’atteinte hépatique: une mise à jour clinique ou ce que tout anesthésiologiste devrait savoir

“…[13][14][15] Si des appareils d'anesthésie permettant de recycler les gaz sont mis au point, l'anesthésie au xénon pourrait être plus économique et, donc, choisie plus volontiers pour des patients sélectionnés qui pourraient bénéficier de l'absence de ses effets systémiques indésirables.…”

“…[13][14][15] If anesthetic delivery systems become available which allow for recycling of anesthetic gases, xenon anesthesia may become more economical and thus more readily available in selected patients who might benefit from its lack of adverse systemic effects.…”

Various Types of Anaesthesia With Xenon in Children

“…However such anesthesia has not received rapid development due to complexity, high cost of obtaining gas and its large consumption during anesthesia. In the late 80s -early 90s in connection with the improvement of anesthesia and respiratory devices, the advent of high-quality gas analyzers and a wave of renewed interest in low flowed anesthesia has resumed interest in xenon [1,2]. Being tolerant NMDA-receptor antagonist, it also has an impact on the GABA-receptors or not NMDA-glutamate ergo receptors, and kaynat receptors [3].…”