Safety and Feasibility of Cervical and Thoracic Transcutaneous Spinal Cord Stimulation to Improve Hand Motor Function in Children With Chronic Spinal Cord Injury

Singh, Goutam; Keller, Anastasia; Lucas, Kathryn; Borders, Catherine; Stout, Danielle; King, Molly; Parikh, Parth; Stepp, Nicole; Ugiliweneza, Beatrice; D’Amico, Jessica M.; Gerasimenko, Yury; Behrman, Andrea L.

doi:10.1016/j.neurom.2023.04.475

Neuromodulation: Technology at the Neural Interface

2024

DOI: 10.1016/j.neurom.2023.04.475

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Safety and Feasibility of Cervical and Thoracic Transcutaneous Spinal Cord Stimulation to Improve Hand Motor Function in Children With Chronic Spinal Cord Injury

Goutam Singh,

Anastasia Keller,

Kathryn Lucas

et al.

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2024

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Cited by 4 publications

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Cardiovascular Effects of Spinal Cord Stimulation: The Highs, the Lows, and the Don’t Knows

Law,

Sachdeva,

Darrow

et al. 2024

Neuromodulation: Technology at the Neural Interface

View full text Add to dashboard Cite

Cardiovascular Effects of Spinal Cord Stimulation: The Highs, the Lows, and the Don’t Knows

Law,

Sachdeva,

Darrow

et al. 2024

Neuromodulation: Technology at the Neural Interface

View full text Add to dashboard Cite

Spinal Cord Transcutaneous Stimulation in Cervical Spinal Cord Injury: A Review Examining Upper Extremity Neuromotor Control, Recovery Mechanisms, and Future Directions

Singh,

Sharma,

Forrest

et al. 2024

Journal of Neurotrauma

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Restorative Treatments for Cervical Spinal Cord Injury, a Narrative Review

Kaleem,

Javeed,

Plog

et al. 2024

Clinical Spine Surgery

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Study Design: A narrative review. Objective: To summarize relevant data from representative studies investigating upper limb restorative therapies for cervical spinal cord injury. Summary of Background Data: Cervical spinal cord injury (SCI) is a debilitating condition resulting in tetraplegia, lifelong disability, and reduced quality of life. Given the dependence of all activities on hand function, patients with tetraplegia rank regaining hand function as one of their highest priorities. Recovery from cervical SCI is heterogeneous and often incomplete; currently, various novel therapies are under investigation to improve neurological function and eventually better quality of life in patients with tetraplegia. Methods: In this article, a narrative literature review was performed to identify treatment options targeting the restoration of function in patients with cervical SCI. Studies were included from available literature based on the availability of clinical data and whether they are applicable to restoration of arm and hand function in patients with cervical SCI. Results: We describe relevant studies including indications and outcomes with a focus on arm and hand function. Different treatment modalities described include nerve transfers, tendon transfers, spinal cord stimulation, functional electrical stimulation, non-invasive brain stimulation, brain-machine interfaces and neuroprosthetics, stem cell therapy, and immunotherapy. As the authors’ institution leads one of the largest clinical trials on nerve transfers for cervical SCI, we also describe how patients undergoing nerve transfers are managed and followed at our center. Conclusions: While complete recovery from cervical spinal cord injury may not be possible, novel therapies aimed at the restoration of upper limb motor function have made significant progress toward the realization of complete recovery.

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Safety and Feasibility of Cervical and Thoracic Transcutaneous Spinal Cord Stimulation to Improve Hand Motor Function in Children With Chronic Spinal Cord Injury

Cited by 4 publications

References 52 publications

Cardiovascular Effects of Spinal Cord Stimulation: The Highs, the Lows, and the Don’t Knows

Cardiovascular Effects of Spinal Cord Stimulation: The Highs, the Lows, and the Don’t Knows

Spinal Cord Transcutaneous Stimulation in Cervical Spinal Cord Injury: A Review Examining Upper Extremity Neuromotor Control, Recovery Mechanisms, and Future Directions

Restorative Treatments for Cervical Spinal Cord Injury, a Narrative Review

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