Safety and immunogenicity of a skin- and neuro-attenuated live vaccine for varicella: a randomized, double-blind, controlled, dose-escalation and age de-escalation phase 1 clinical trial

Mo, Zhaojun; Huang, Shou-Jie; Qiu, Lingxian; Li, Changgui; Yu, Xiao‐Juan; Li, Mingqiang; Chen, Zhe; Zhong, Guohua; Pan, Di; Huang, Lirong; Lv, Bang-Jun; Cui, Xuelian; Song, Qiao-Qiao; Jia, Jizong; Han, Jian; Wang, Wei; Zhu, Hua; Cheng, Tong; Su, Yingying; Li, Yimin; Ye, Xiangzhong; Wu, Ting; Zhang, Jun; Xia, Ningshao

doi:10.1016/j.lanwpc.2023.100707

Cited by 2 publications

(1 citation statement)

References 40 publications

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“…ORF7 knockout reduced the risk of skin and nervous system complications associated with the vOka vaccine while maintaining immunogenicity [ 103 , 106 , 107 ]. v7D has become a promising and safer candidate for the live-attenuated varicella vaccine [ 108 ]. With increased safety, v7D could also be a promising delivery vector for gene therapy.…”

Section: Application Of Bac-based Gene Editing In Herpesvirus Researchmentioning

confidence: 99%

Bacterial-Artificial-Chromosome-Based Genome Editing Methods and the Applications in Herpesvirus Research

Hao

Tang

et al. 2023

Microorganisms

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Herpesviruses are major pathogens that infect humans and animals. Manipulating the large genome is critical for exploring the function of specific genes and studying the pathogenesis of herpesviruses and developing novel anti-viral vaccines and therapeutics. Bacterial artificial chromosome (BAC) technology significantly advanced the capacity of herpesviruses researchers to manipulate the virus genomes. In the past years, advancements in BAC-based genome manipulating and screening strategies of recombinant BACs have been achieved, which has promoted the study of the herpes virus. This review summarizes the advances in BAC-based gene editing technology and selection strategies. The merits and drawbacks of BAC-based herpesvirus genome editing methods and the application of BAC-based genome manipulation in viral research are also discussed. This review provides references relevant for researchers in selecting gene editing methods in herpes virus research. Despite the achievements in the genome manipulation of the herpes viruses, the efficiency of BAC-based genome manipulation is still not satisfactory. This review also highlights the need for developing more efficient genome-manipulating methods for herpes viruses.

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Section: Application Of Bac-based Gene Editing In Herpesvirus Researchmentioning

confidence: 99%

Bacterial-Artificial-Chromosome-Based Genome Editing Methods and the Applications in Herpesvirus Research

Hao

Tang

et al. 2023

Microorganisms

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show abstract

Molecular engineering tools for the development of vaccines against infectious diseases: current status and future directions

Xue

et al. 2023

Expert Review of Vaccines

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Safety and immunogenicity of a skin- and neuro-attenuated live vaccine for varicella: a randomized, double-blind, controlled, dose-escalation and age de-escalation phase 1 clinical trial

Cited by 2 publications

References 40 publications

Bacterial-Artificial-Chromosome-Based Genome Editing Methods and the Applications in Herpesvirus Research

Bacterial-Artificial-Chromosome-Based Genome Editing Methods and the Applications in Herpesvirus Research

Molecular engineering tools for the development of vaccines against infectious diseases: current status and future directions

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