Safety and technique of ferumoxytol administration for MRI

Vasanawala, Shreyas S.; Nguyen, Kim‐Lien; Hope, Michael D.; Bridges, Mellena D.; Hope, Thomas A.; Reeder, Scott B.; Bashir, Mustafa R.

doi:10.1002/mrm.26151

Cited by 183 publications

(166 citation statements)

References 51 publications

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“…In practice, it was challenging to run both approaches in the same patients because that would require two separate imaging sessions. Guidelines for Ferumoxytol administration at our institution require that the USPIO contrast should be slowly infused in the nursing station under close monitoring [16]. However, the two groups studied were roughly equal in size, age, and indication for imaging (mainly aortic valve replacement and aortic dilation).…”

Section: Discussionmentioning

confidence: 99%

“…In a previous publication, we found USPIO MRA had comparable measurement of aortic annulus area with trans-esophageal echocardiography (TEE) as the gold standard using a similar 3D MRA protocol [8]. The blood pool contrast agent used (ferumoxtyol) has a higher reported incidence of anaphylaxis than gadolinium (1:10,000) [16]. We followed the recommended safety precautions to minimize the risk of allergic reaction, including the slow infusion of contrast in the nursing holding area with continuous monitoring before the MRI, and also obtained consent prior to contrast administration [16].…”

Section: Discussionmentioning

confidence: 99%

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Gated thoracic magnetic resonance angiography at 3T: noncontrast versus blood pool contrast

Zhu

Haraldsson

Kallianos

et al. 2017

Int J Cardiovasc Imaging

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Both noncontrast and contrast-enhanced approaches to gated thoracic magnetic resonance angiography (MRA) for aortic root evaluation have been reported at 3T. We compare qualitative and quantitative image quality measures for the two approaches, and assess the reproducibility of standard aortic measurements. Respiratory and cardiac gated MRA of the chest was performed at 3T in 45 patients: 23 after administration of iron-based blood pool contrast, and 22 without contrast. Image quality was assessed with a 5-point Likert scale, vessel lumen-to-muscle contrast ratios, and vessel wall sharpness. Two reviewers measured the ascending aorta diameter and valve annulus area. Interrater agreement was assessed using Bland–Altman plots and coefficient of variation (CV). Qualitative image quality was better with blood pool contrast in all principal vessels of the chest (mean Likert of 4.20 ± 0.79 vs. 2.60 ± 0.77, p < 0.001). Quantitative assessment was also improved with higher contrast ratios in all vessels (5.26 ± 3.3 vs. 1.90 ± 0.53, p < 0.001), and greater sharpness of the aortic annulus and ascending aorta (0.70 ± 0.16 vs. 0.56 ± 0.14 mm−1, p < 0.001, and 0.87 ± 0.16 vs. 0.62 ± 0.16 mm−1, p = 0.008, respectively). Reproducibility of measurement was marginally better for the ascending aorta diameter (CV of 2.80 vs. 3.23%), but substantially increased for the aortic valve annulus area with blood pool contrast (CV of 4.93 vs. 7.32%). The use of a blood pool contrast agent for gated thoracic MRA improves image quality compared to a noncontrast technique, and provides more reproducible measurements of the aortic valve annulus area.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Gated thoracic magnetic resonance angiography at 3T: noncontrast versus blood pool contrast

Zhu

Haraldsson

Kallianos

et al. 2017

Int J Cardiovasc Imaging

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“…For a translational approach, toxicity assessments should be performed on case by case basis. A number of clinical safety issues of clinical approved SPIO have been described, thought the incidence is overall uncommon (14)(15)(16)(17)(18)(19). Importantly, SPIO is not indicated in pregnant women.…”

Section: A B C D E C B Amentioning

confidence: 99%

A comprehensive literatures update of clinical researches of superparamagnetic resonance iron oxide nanoparticles for magnetic resonance imaging

Wáng

Idée

2017

Quant. Imaging Med. Surg.

199

116

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“…There has been great interest in using USPIO contrast agents due to lack of renal excretion and absence of NSF risk; however, initial postmarket studies in adults have reported a risk of cardiac adverse events and anaphylaxis that is higher than with GBCA (26). In addition, these agents are taken up by the reticuloendothelial system and are retained for weeks to several months and may lead to an additional risk of iron overload with repeat doses.…”

Section: Mri Risksmentioning

confidence: 99%

Pediatric Cancer Predisposition Imaging: Focus on Whole-Body MRI

Greer

Voss

States

2017

Clinical Cancer Research

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The American Association for Cancer Research convened a meeting of international pediatric oncologists, geneticists, genetic counselors, and radiologists expert in childhood cancer predisposition syndromes (CPS) in October 2016 to propose consensus surveillance guidelines. Imaging plays a central role in surveillance for most, though not all, syndromes discussed. While encompassing the full gamut of modalities, there is increasing emphasis on use of nonionizing radiation imaging options such as magnetic resonance imaging (MRI) in children and adolescents, especially in the pediatric CPS population. In view of rapid evolution and widespread adoption of whole-body MRI (WBMRI), the purpose of our review is to address WBMRI in detail. We discuss its place in the surveillance of a range of pediatric CPS, the technical and logistical aspects of acquiring and interpreting these studies, and the inherent limitations of WBMRI. We also address issues associated with sedation and use of gadolinium-based contrast agents in MRI in children.

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Safety and technique of ferumoxytol administration for MRI

Cited by 183 publications

References 51 publications

Gated thoracic magnetic resonance angiography at 3T: noncontrast versus blood pool contrast

Gated thoracic magnetic resonance angiography at 3T: noncontrast versus blood pool contrast

A comprehensive literatures update of clinical researches of superparamagnetic resonance iron oxide nanoparticles for magnetic resonance imaging

Pediatric Cancer Predisposition Imaging: Focus on Whole-Body MRI

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