Safety Assessment of<i>Panax</i>spp Root-Derived Ingredients as Used in Cosmetics

Becker, Lillian C.; Bergfeld, Wilma F.; Belsito, D.; Hill, Ronald A.; Klaassen, Curtis D.; Liebler, Daniel C.; Marks, James G.; Shank, Ronald C.; Slaga, Thomas J.; Snyder, Paul W.; Andersen, F. Alan

doi:10.1177/1091581815610508

Cited by 5 publications

(6 citation statements)

References 135 publications

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“…It also inhibits osteoclastogenesis and prevents bone loss (Goto et al, 2015). Caffeic acid is one of the natural compounds of CX (Li et al, 2012), and it is a component of CXCTS, JWPWS, RS (Becker et al, 2015), LHT, DG (Li et al, 2009), DGLHuiW, and GC (Conidi et al, 2019). Caffeic acid shows suppresses bone destruction (Tang et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Chinese Herbal Medicine Usage Reduces Overall Mortality in HIV-Infected Patients With Osteoporosis or Fractures

et al. 2021

Front. Pharmacol.

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The survival of patients with HIV has greatly improved, due to Anti-Retroviral Therapy (ART). However, long-term HIV survivors often develop serious bone abnormalities, possibly due to the interplay of osteoblasts, osteoclasts, HIV ad ART. We evaluated in a nation-wide study in Taiwan the effect of Chinese herbal medicine (CHM) on overall mortality in HIV patients with osteoporosis or fractures. Enrollment period was between 1998 and 2011. Patients with osteoporosis or fractures before the HIV infection, and those with less than 14 days CHM use, were excluded. This left 498 patients, 160 CHM users, 338 without CHM. Univariate Kaplan-Meier and multivariate Cox regression analysis were used to compare the overall mortality in these 2 groups. Due to the nature of Chinese medicine, CHMs inevitably varied. We therefore also used rule mining and network analysis to determine which major CHM clusters were prescribed to the patients. CHM users had a much Lower mortality (hazard ratio (HR) = 0.43, 95% confidence interval (CI): 0.24–0.77, p < 0.005) and higher survival (p = 0.004, log-rank test). Although the CHMs greatly varied, network analysis identified one main cluster of strongly related CHM combinations (Chuan-Xiong-Cha-Tiao-San (CXCTS), Gan-Cao (GC; Glycyrrhiza uralensis Fisch.), Liu-He-Tang (LHT), Huang-Qin-Tang (HQT), Jia-Wei-Ping-Wei-San (JWPWS), and Dang-Gui-Long-Hui-Wan (DGLHuiW)). CHM as an additional treatment strongly improves overall survival in HIV-infected patients with osteoporosis and fractures.

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Section: Discussionmentioning

confidence: 99%

Chinese Herbal Medicine Usage Reduces Overall Mortality in HIV-Infected Patients With Osteoporosis or Fractures

et al. 2021

Front. Pharmacol.

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“…With increasing interest targeted on the use of natural products to treat diseases, PNS have been identified as a safe and effective candidate and recent studies have achieved promising results. PNS had an anti-hyperglycemic, anti-obesity and anti-inflammatory effect and prevented kidney pathological changes in a diabetic mouse model and cell line [10,[19][20][21]. In this study, we used the C2C12 cell line and KKAy mice as a model.…”

Section: Discussionmentioning

confidence: 99%

Panax notoginseng saponins alleviate skeletal muscle insulin resistance by regulating the IRS1–PI3K–AKT signaling pathway and GLUT4 expression

et al. 2019

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Panax notoginseng saponins ( PNS ) are a commonly used traditional medicine to treat diabetes in China. Recent studies have confirmed their anti‐diabetic effects, but the underlying mechanisms have remained unclear. The present study was designed to explore whether PNS decrease hyperglycemia by improving insulin sensitivity in skeletal muscle and to elucidate the molecular mechanisms. The anti‐diabetic effects of PNS were analyzed in a skeletal myoblast cell line, C2C12, and in high fat diet‐induced diabetic KKA y mice. C2C12 cells were treated with PNS (50, 100, and 200 μg·L −1 ) and examined for glucose uptake, cell viability and expression of components of the phosphoinositide 3‐kinase ( PI 3K)–protein kinase B ( AKT ) signaling pathway. KKA y mice were intraperitoneally injected with PNS (200 mg·kg −1 ) for 6 weeks. Body weight, blood glucose, serum insulin, serum lipid, glucose and insulin tolerance were measured to evaluate the anti‐diabetic effects of PNS . Pathological changes, apoptosis and the PI 3K– AKT signaling pathway were analyzed in KKA y skeletal muscle. PNS significantly increased insulin‐induced glucose uptake, but did not affect the cell viability of C2C12 cells. In addition, PNS reduced blood glucose and serum insulin levels and improved glucose tolerance and insulin tolerance of KKA y mice. Pathological changes and apoptosis of skeletal muscle were relieved by PNS treatment. Moreover, PNS treatment enhanced expression of mRNA encoding IRS 1 and GLUT 4, as well as the protein expression of phosphorylated (p) ‐insulin receptor substrate 1 ( IRS 1), p‐ PI 3K, p‐ AKT and glucose transporter type 4 ( GLUT 4) in C2C12 and KKA y mouse muscle. Collectively, these data indicate that PNS reduces hyperglycemia and insulin resistance through up‐regulating GLUT 4 expression and the IRS 1– PI 3K– AKT signaling pathway. Furthermore, PNS alleviated diabetes skeletal muscle pathological damage. Thus, our data suggest that PNS may be promising anti‐diabetic compounds.

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“…This is the reason this plant is referred to in China as "sān-qī," meaning "the three-seven herb." P. notoginseng is either cultivated or gathered from the wild, and the interest in this plant is particularly for its root and rhizome which are used to prepare foods, health products, beauty products, dietary supplements, and medicines [182].…”

Section: Clusiaceae: Garcinia Mangostana Lmentioning

confidence: 99%

“…P. notoginseng root and rhizome extracts as well as purified notoginsenosides or notoginsenoside-containing formulations have also been used for thousands of years in traditional Chinese medicine for treating the symptoms of diabetes [182]. The results from many pharmacological studies-both in vivo and in vitro-have supported this use [189,190].…”

Section: Plants With Hypoglycemic Properties Associated Withmentioning

confidence: 99%

Hypoglycemic Activity of Plant-Derived Traditional Preparations Associated with Surinamese from African, Hindustani, Javanese, and Chinese Origin: Potential Efficacy in the Management of Diabetes Mellitus

Mans¹

2022

Basics of Hypoglycemia

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Diabetes represents one of the most frequent causes of morbidity and mortality in the world. Despite the availability of a wide range of efficacious forms of treatment, many patients use traditional (plant-derived) preparations for treating their disease. The Republic of Suriname (South America) has a relatively high prevalence of diabetes. Due to its colonial history, the Surinamese population comprises descendants of all continents, the largest groups being those from enslaved Africans and from indentured laborers from India (called Hindustanis), Indonesia (called Javanese), as well as China. All these groups have preserved their cultural customs including their ethnopharmacological traditions, and are inclined to treat their diseases with plant-based preparations, either alone or together with allopathic medications. This chapter opens with some generalities about diabetes; subsequently provides some information about the history, worldwide epidemiology, diagnosis, types, and treatment of this disorder; then focuses on Suriname, giving some information about its geography, demographics, and economy, as well as the epidemiology of diabetes in the country; then extensively evaluates eight blood-glucose-lowering plants that are mainly associated with the four largest ethnic groups in Suriname by reviewing phytochemical, mechanistic, preclinical, and clinical literature data; and concludes with a consideration of the potential clinical usefulness of the plants against diabetes.

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Safety Assessment ofPanaxspp Root-Derived Ingredients as Used in Cosmetics

Cited by 5 publications

References 135 publications

Chinese Herbal Medicine Usage Reduces Overall Mortality in HIV-Infected Patients With Osteoporosis or Fractures

Chinese Herbal Medicine Usage Reduces Overall Mortality in HIV-Infected Patients With Osteoporosis or Fractures

Panax notoginseng saponins alleviate skeletal muscle insulin resistance by regulating the IRS1–PI3K–AKT signaling pathway and GLUT4 expression

Hypoglycemic Activity of Plant-Derived Traditional Preparations Associated with Surinamese from African, Hindustani, Javanese, and Chinese Origin: Potential Efficacy in the Management of Diabetes Mellitus

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