Safety assessment of potential probiotic lactic acid bacterial strains Lactobacillus rhamnosus HN001, Lb. acidophilus HN017, and Bifidobacterium lactis HN019 in BALB/c mice

Zhou, Joseph S.; Qin, Shu; Rutherfurd, Kay J.; Prasad, Jaya; Birtles, M. J.; Gopal, Pramod K.; Gill, H. S.

doi:10.1016/s0168-1605(00)00219-1

Cited by 119 publications

(92 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Concerning the haematology, no significant differences were observed after L. fermentum AD1 application. These results agree with the findings of Zhou et al (2000), who tested potential probiotic lactic acid bacterial strains L. rhamnosus, L. acidophilus and Bifidobacterium lactis in mice. The enzyme glutathione peroxidase, a component of the antioxidative defence system, was not affected.…”

Section: Discussionsupporting

confidence: 92%

New probiotic strain Lactobacillus fermentum AD1 and its effect in Japanese quail

Strompfová¹,

Marciňáková²,

Gancarčíková³

et al. 2005

Vet. Med. - Czech

View full text Add to dashboard Cite

ABSTRACT:Probiotics have been used with increasing frequency in nutrition and for prophylactic purposes during the last years. In the present study we investigated the effect of Lactobacillus fermentum AD1 -canine isolate on selected intestinal microbial groups, weight gain, organic acids, haematology, glutathione peroxidase and phagocytosis of leucocytes in 2-days-old Japanese quail (Coturnix coturnix japonica). The results demonstrated that the 4-day application of this strain significantly increased the population of lactic acid bacteria -lactobacilli and enterococci in faeces (P < 0.01 and/or P < 0.001) and caecum of quail (P < 0.001) and significantly decreased the counts of E. coli in faeces (P < 0.05). The daily weight gain was increased by 14%. Although intestinal pH of both groups of birds was similar, the concentration of lactic acid was significantly increased in the experimental group (P < 0.05). The concentration of other organic acids (acetic, acetoacetic, formic, succinic, valeric, propionic, butyric) as well as blood glutathione peroxidase was not influenced. The index of phagocytic activity of leucocytes was significantly improved (P < 0.01).

show abstract

Section: Discussionsupporting

confidence: 92%

New probiotic strain Lactobacillus fermentum AD1 and its effect in Japanese quail

Strompfová¹,

Marciňáková²,

Gancarčíková³

et al. 2005

Vet. Med. - Czech

View full text Add to dashboard Cite

show abstract

“…No noticeable activity or behavioral changes were observed in mice during the experimental protocol, and no illness or death occurred. Oral administration of different doses of L. salivarius REN caused no significant difference in BW, food intake, and tissue weight among the groups throughout the experiment (Table 1), which are similar with previous reports (Zhou et al, 2000;Lara-Villoslada et al, 2007a). These results demonstrate that L. salivarius REN does not exhibit gross nutrient metabolism (Swendseid, 1987), which usually apparent before any clinical symptoms (Zhou et al, 2000).…”

Section: Methodssupporting

confidence: 91%

“…Oral administration of different doses of L. salivarius REN caused no significant difference in BW, food intake, and tissue weight among the groups throughout the experiment (Table 1), which are similar with previous reports (Zhou et al, 2000;Lara-Villoslada et al, 2007a). These results demonstrate that L. salivarius REN does not exhibit gross nutrient metabolism (Swendseid, 1987), which usually apparent before any clinical symptoms (Zhou et al, 2000). The changes of serum biochemical parameters might indicate responsive organs were affected or even damaged (Swendseid, 1987).The current study showed that oral administration of L. salivarius REN for 28 days had no adverse effects on the hematology and blood biochemistry (Table 2).…”

Section: Methodssupporting

confidence: 91%

“…Blood samples were collected into EDTA-containing tubes by cardiac puncture in sterile conditions, and serum oral toxicity on the animals' health status, growth and development, even in high dose groups. In order to evaluate the adverse sub-clinical effects of L. salivarius REN, hematological and general blood biochemical parameters were monitored (Zhou et al, 2000). Hematological parameters are usually used to represent the deleterious effects of test substance on the blood (Lee et al, 2010), when the composition of blood cells change, it might indicate the pathological changes in bone marrow or the reaction of immune cells (Yakubu et al, 2007).…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Safety Assessment of Lactobacillus salivarius REN, a Probiotic Strain Isolated from Centenarian Feces

Zhang¹,

Sun²,

Wang³

et al. 2013

FSTR

View full text Add to dashboard Cite

The aim of this study was to evaluate the oral safety of Lactobacillus salivarius REN, a probiotic isolated from the fecal samples of a healthy centenarian. BALB/c mice were respectively orally administered with 0, 3 × 10 8 , 5 × 10 9 , or 2 × 10 10 CFU/mouse daily for 28 days, or injected intraperitoneally with 5 × 10 9 CFU/mouse in a single dose, then killed at day 2 and day 5 after injection, respectively. The results indicated that oral administration of Lactobacillus salivarius REN had no adverse effects on body weight, food intake, hematological and serum biochemical parameters, and there was no treatment-associated bacterial translocation to the blood, liver, spleen, or kidney. Intraperitoneal injection caused bacterial translocation to the liver, spleen, and kidney, except blood, the translocation did not trigger illness or death. This study suggests Lactobacillus salivarius REN is likely to be safe for human consumption.

show abstract

“…All these observations give information on the safety of viable administration of the test strain Enterococcus faecium MBTU-P1F1 as a probiotic. Assessment of pathogenicity is one of the important components of probiotic safety studies, the indicators for which include splenomegaly and hepatomegaly (Zhou et al, 2000). Figure 6a, 6b, 6c and 6d represent the photomicrographs of the intestinal sections of the test group mice and the control group mice.…”

Section: Safety Of Viable Oral Administration Of Enterococcus Faeciummentioning

confidence: 99%

Phenotypic Safety Assessment and Molecular Characterization of Enterococcus feacium MBTU-P1F1 (KF745071) from Infant feces

Jacob¹,

Keerthi²,

Resmi³

2017

Int.J.Curr.Microbiol.App.Sci

View full text Add to dashboard Cite

Safety assessment of potential probiotic lactic acid bacterial strains Lactobacillus rhamnosus HN001, Lb. acidophilus HN017, and Bifidobacterium lactis HN019 in BALB/c mice

Cited by 119 publications

References 29 publications

New probiotic strain Lactobacillus fermentum AD1 and its effect in Japanese quail

New probiotic strain Lactobacillus fermentum AD1 and its effect in Japanese quail

Safety Assessment of Lactobacillus salivarius REN, a Probiotic Strain Isolated from Centenarian Feces

Phenotypic Safety Assessment and Molecular Characterization of Enterococcus feacium MBTU-P1F1 (KF745071) from Infant feces

Contact Info

Product

Resources

About