Safety Assessment of Transgenic Potatoes with Soybean Glycinin by Feeding Studies in Rats

Hashimoto, Wataru; Momma, Keiko; Yoon, Hye‐Jin; Ozawa, Shinji; Ohkawa, Yasunobu; Ishige, Teruo; Kito, Makoto; Utsumi, Shigeru; Murata, Kousaku

doi:10.1271/bbb.63.1942

Cited by 41 publications

(28 citation statements)

References 8 publications

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“…Much of this research has been done with rats (Hasimoto et al 1999;Sidhu et al 2000) or pigs (Böhme and Aulrich 1999; Spencer et al 2000;Weber et al 2000;Cromwell et al 2002) and may not be applicable to ruminants. Additionally, the ruminant feeding studies that have been done have usually involved the Bacillus thuringiensis (Bt) gene in corn that confers insect tolerance (Faust 2000;Hendrix et al 2000;Flachowsky and Aulrich 2001).…”

Section: Growth Performancementioning

confidence: 99%

Effects of feeding transgenic canola on apparent digestibility, growth performance and carcass characteristics of lambs

Stanford¹,

Aalhus²,

Dugan³

et al. 2003

Can. J. Anim. Sci.

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. 2003. Effects of feeding transgenic canola on apparent digestibility, growth performance and carcass characteristics of lambs. Can. J. Anim. Sci. 83: 299-305. This study evaluated the effects of including meal from glyphosate-tolerant (Roundup-Ready ® ) canola (RRC) in barley-based diets for lambs on apparent digestibility of the diets, growth performance of the lambs, and carcass quality and composition. Four isonitrogenous diets were prepared that included canola meal [6.5%, dry matter (DM) basis] from four different sources (two commercially available canola blends, COM1 and COM2; a transgenic line, RRC and the parental non-transgenic line from which RRC was derived, PAR). Apparent digestibilities of the four diets were determined using eight mature wethers (67.8 ± 2.3 kg) in a replicated Latin square with four 21-d periods. No aspect of digestibility (DM, fibre, or nitrogen balance) was influenced by canola source. The growth trial involved 60 earlyweaned Arcott lambs (30 ewes; 30 wethers; initial age approximately 2 mo; initial weight 21.5 ± 1.0 kg). The lambs were blocked by weight and gender for assignment to treatments, and fed the diets until reaching or exceeding 45 kg body weight. Intake of DM was similar among lambs fed COM1, COM2 and PAR diets, and between PAR and RRC (COM1, COM2 > RRC, P < 0.05). Diet did not affect (P > 0.05) average daily gain or feed efficiency. Carcass yield grade was higher (P < 0.05) for COM1 and COM2 diets than for PAR or RRC, although carcass composition did not differ (P > 0.05) between PAR and RRC. Canola source did not affect (P > 0.05) meat tenderness, as determined by shear force, drip loss or intramuscular fat content. Meat colour of RRC-fed lambs did not differ from that of all other treatment groups. In this study, including canola meal prepared from glyphosate-tolerant canola did not alter diet digestibility, feed efficiency, growth performance, carcass characteristics or meat quality of lambs.Key words: Growth, lambs, meat quality, ruminant, transgenic canola Stanford, K., Aalhus, J. L., Dugan, M. E. R., Wallins, G. L., Sharma, R. et McAllister, T. A. 2003. Digestibilité apparente des aliments, performance de la croissance et paramètres de la carcasse chez les agneaux nourris de canola transgénique. Can. J. Anim. Sci. 83: 299-305. Les auteurs ont évalué l'incidence du tourteau de canola tolérant le glyphosate (Roundup-Ready ® ) (CTG) ajouté à la ration à base d'orge des agneaux sur la digestibilité apparente des aliments, la croissance des animaux ainsi que la qualité et la composition de la carcasse. Pour cela, ils ont préparé quatre rations isoazotées avec du tourteau de canola (6,5 % de la matière sèche (MS)) de quatre sources (deux mélanges de canola vendus dans le commerce, COM1 et COM2; une lignée transgénique, CTG; la lignée parentale non transgénique d'où était issue la précédente, PAR). Les auteurs ont établi la digestibilité apparente des quatre aliments avec huit moutons (67,8 ± 2,3 kg) dans le cadre d'une double expérience en carré latin menée pendan...

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Section: Growth Performancementioning

confidence: 99%

Effects of feeding transgenic canola on apparent digestibility, growth performance and carcass characteristics of lambs

Stanford¹,

Aalhus²,

Dugan³

et al. 2003

Can. J. Anim. Sci.

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“…Hopefully, no food or feed additive is so toxic as to give adverse effects with the small dose used by Hashimoto et al (1999).…”

Section: Commentsmentioning

confidence: 99%

“…The work in five studies (Noteborn et al, 1995;Hammond et al, 1996, Brake andVlachos, 1998;Hashimoto et al, 1999, Teshima et al, 2000 was regarded as having been performed more or less in collaboration with private companies. In none of these studies were effects related to GM-materials reported.…”

Section: Commentsmentioning

confidence: 99%

“…A drawback in this study is that no histological examinations are reported. Hashimoto et al (1999) utilised two GM-potatoes developed at a Japanese research institute, both expressing a glycinin, one a native glycinin, the other a designed glycinin with four methionyl residues in the molecule. A commercial diet (no composition given) was fed to four groups of male rats four weeks of age for 28 days.…”

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confidence: 99%

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In Vivo Studies on Possible Health Consequences of Genetically Modified Food and Feed—with Particular Regard to Ingredients Consisting of Genetically Modified Plant Materials

Pryme

Lembcke²

2003

Nutr Health

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This synopsis reviews published in vivo studies on possible health consequences of genetically modified food and feed where the ingredients in question have consisted of genetically modified plant materials. The following, however, have not been taken into consideration:-ingredients consisting of genetically modified microorganisms or parts of animals/fish -ingredients produced by/from genetically modified organisms but without any DNA present -studies on consequences for the environment or biodiversity -in vitro studies or computer simulations According to a Norwegian report "Gen-mat" (NOU 2000:29), and a more recent search in Medline and Citations Index, to our knowledge a total of ten studies have been published on the health effects of GM-foods and feeds. In this minireview the data made available in these published studies is discussed.In their study Noteborn et al (1995) used a GM-tomato developed at a Dutch research institute, with a gene expressing the Bt Cry1A(b) toxin. The toxin was expressed at as little as 7,5 ng/mg protein in the fresh GM-tomato. A commercial semi-synthetic animal feed (no composition given), and the same feed mixed with 10% of lyophilised tomatoes (the GM-tomato or the unmodified parent) were fed to young male and female rats (weanlings) for 91 days. Rats given tomato-diets ate on average what corresponds to 20 g of fresh tomatoes a day. Percent survivals, terminal body weights and organ weights

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“…The results of a few in vivo experiments of other authors (Hashimoto et al, 1999;Rogan et al, 2000;Zduńczyk et al, 2004a,b) indicate that tubers of potato with genetically improved virus-or insect-resistance were nutritional equivalents of their conventional counterparts. In the presented study tubers of the conventional cultivar Irga and transgenic clones RIF, R2P and NTR1.16 exerted a similar influence on the fermentation processes in the caecum of rats.…”

Section: Discussionmentioning

confidence: 97%

Caecal fermentation in rats fed diets containing transgenic potato tubers

Juśkiewicz¹,

Zduńczyk²,

Frejnagel³

et al. 2004

J. Anim. Feed Sci.

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Safety Assessment of Transgenic Potatoes with Soybean Glycinin by Feeding Studies in Rats

Cited by 41 publications

References 8 publications

Effects of feeding transgenic canola on apparent digestibility, growth performance and carcass characteristics of lambs

Effects of feeding transgenic canola on apparent digestibility, growth performance and carcass characteristics of lambs

In Vivo Studies on Possible Health Consequences of Genetically Modified Food and Feed—with Particular Regard to Ingredients Consisting of Genetically Modified Plant Materials

Caecal fermentation in rats fed diets containing transgenic potato tubers

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