With the COVID-19 pandemic, supply chains are today confronted with more uncertainties than ever before. In the face of unanticipated disruptions, being resilient and sustainable has been rewarding for supply chains in terms of competitive advantage. However, literature is still far from possessing an encompassing sustainable supply chain framework (SSCF). As a contribution to the extant literature, the present study expounds a prominent concept termed negative entropy and explores its role in the SSCF. To accomplish this goal, the effect of negative entropy on supply chain sustainability is tested. Following the open systems theory and drawing from the collaboration and information management aspects of the negative entropy, co-creation, open innovation and network governance concepts which are considered to be relevant in this context are selected to be the antecedents of negative entropy. The empirical research is conducted on prominent logistics service providers and firms from various sectors with approved research and development departments in Turkey. The obtained data were subjected to covariance-based structural equation modeling analysis via Lisrel program. According to results, negative entropy is found to be a robust element in explaining supply chain sustainability. Furthermore, whereas co-creation and network governance reflected significant effects on negative entropy, surprisingly, open innovation demonstrated no substantial impact. This paper opens up a new front in sustainable supply chain management studies with a notable empirical study introducing negative entropy in the context of open systems theory.