Safety, efficacy, and immunogenicity of a modified-live equine influenza virus vaccine in ponies after induction of exercise-induced immunosuppression

Abstract

Results suggested that administration of this MLV vaccine to ponies with exercise-induced immunosuppression was safe and that administration of a single dose to ponies provided clinical protection 3 months later.

Attenuation of Equine Influenza Viruses through Truncations of the NS1 Protein

“…; Heska Corp.) has shown more promising results. Efficacy trials of this vaccine showed animals were clinically protected 3 months after vaccination (14) and had reduced severity of disease with significant clinical protection 6 months after vaccination (35).…”

Modifications in the Polymerase Genes of a Swine-Like Triple-Reassortant Influenza Virus To Generate Live Attenuated Vaccines against 2009 Pandemic H1N1 Viruses

“…vaccine; Intervet) has been developed for horses and is available commercially in North America (53). Field experience with both the human and the equine live influenza vaccines have demonstrated the safety, effectiveness, and genetic and phenotypic stability of these vaccine platforms (7,8,11,14,41,53,56,65,67).…”

Resposta hematológica de cavalos de enduro, que correram diferentes distâncias, no período pós-prova

“…Robson et al (2003) encontraram neutrofilia e linfopenia evidentes uma hora e um dia após enduro de 80km, retornando à normalidade somente três dias após, como ocorreu no presente estudo. Alguns autores (Kurcz et al, 1998;Lunn et al, 2001), que trabalharam com cavalos em esteira rolante de alta velocidade, encontraram supressão da resposta proliferativa de linfócitos, porém Cywińska et al (2012) encontraram diminuição dessa resposta somente em cavalos de longa distância (160km) e não nos cavalos de regularidade.…”