Safety evaluation of a newly-developed dietary fiber: resistant glucan mixture

Abstract

Resistant glucan mixture (RGM), a water-soluble dietary fiber produced by the random polymerization of glucose with activated carbon as a catalyst at a high temperature, has been recently developed by our group. There has been little physiological and safety research into RGM and therefore we now present our research into its safety. A reverse mutation assay indicated that RGM is not mutagenic either with or without metabolic activation. We conducted a 90-day subchronic oral toxicity study in rats. Male and female rats fed either a 3% or 5% w/w RGM diet had no muddy or watery stools, and there was no RGM-related death in any group. Although some parameters in the 3% and 5% w/w groups were significantly different from those in the control group, these changes were not due to any toxicity from RGM. The results indicated that the No Observed Adverse Effect Level (NOAEL) of RGM was 3.3 and 3.9 g/kg body weight (BW) per day in male and female rats, respectively. We then studied the gastrointestinal effects of RGM in healthy adult humans. Gastrointestinal symptoms, such as gurgling sounds, flatus and tenesmus, were mild and transient. In men and women, the maximum no-effect dose for diarrhea was more than 0.9 g RGM /kg BW. The results of our current safety assessment studies suggest that RGM is safe for human consumption.

Ultrasonic Method to Synthesize Glucan-g-poly(acrylic acid)/Sodium Lignosulfonate Hydrogels and Studies of Their Adsorption of Cu2+ from Aqueous Solution

“…Therefore, a value-added utilization method of sodium lignosulfonate can be beneficial to not only the biorefinery process, but also to the pulping industry. , Glucan, a group of polysaccharides, is present in the cell walls and well-tolerated by humans and animals . It has the effect of scavenging free-radicals, antiradiation, dissolving cholesterol and preventing hyperlipidemia and is widely used in medicine, food, cosmetics and other industries …”

“…26 It has the effect of scavenging free-radicals, antiradiation, dissolving cholesterol and preventing hyperlipidemia and is widely used in medicine, food, cosmetics and other industries. 27 The study is aimed to synthesize GL-g-PAA, SLS-g-PAA, and GL-g-PAA/SLS hydrogels via ultrasonic solution polymerization and use them as adsorbents to remove the Cu 2+ ion from aqueous solutions. The parameters that influence the adsorption capacity of the hydrogels were studied such as pH, temperature, adsorbent dosage, and contact time as well as initial concentration.…”

Therapeutic effects of soluble dietary fiber consumption on type 2 diabetes mellitus

“…The present study aimed to investigate the effects of DF on glycemic control and plasma lipid concentrations in patients with DM2. Patients were administered DF at doses greater than the ADA-recommended level of 25-35 g in order to elucidate how a high-fiber diet may affect plasma cholesterol levels, intestinal cholesterol absorption and fecal sterol excretion (11).…”