Safety evaluation of auraptene in rats in acute and subacute toxicity studies

Vakili, Tooraj; Iranshahi, Mehrdad; Arab, Hossein-Ali; Riahi, Bamdad; Roshan, Nama Mohammadian; Karimi, Gholamreza

doi:10.1016/j.yrtph.2017.10.025

Cited by 28 publications

(21 citation statements)

References 24 publications

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“…For a antiviral drug candidate, safety is the top concern. Acute and subacute toxicity are the two important index for drug safety evaluation ( Vakili et al, 2017 ), which can help to determine the scope and the time of the drug use, reduce side effects. In this study, we fed Ae to mice and determined a safe dose of 100 mg/kg of bw by recording the deaths, weight changes and blood cell counts of Ae-treatmented mice.…”

Section: Discussionmentioning

confidence: 99%

Aloe extract inhibits porcine epidemic diarrhea virus in vitro and in vivo

Liu

Peng

et al. 2020

Veterinary Microbiology

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Highlights Aloe extract inhibits PEDV replication in Vero and IPEC-J2 cells in vitro. Aloe extract can inactivate PEDV virions directly. Oral administration of Aloe extract can protect newborn piglets against PEDV infection in vivo .

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Section: Discussionmentioning

confidence: 99%

Aloe extract inhibits porcine epidemic diarrhea virus in vitro and in vivo

Liu

Peng

et al. 2020

Veterinary Microbiology

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“…Auraptene (AUR), a coumarin‐related compound, is isolated from citrus fruit. [ 139 ] AUR treatment significantly induced Nrf2 expression in rotenone‐treated cells. Nrf2 is a cellular sensor of rotenone‐induced oxidative stress.…”

Section: Protective Effects Of Natural Compounds Against Rotenone‐indmentioning

confidence: 99%

The protective effect of natural compounds against rotenone‐induced neurotoxicity

Yarmohammadi

Hayes

Najafi

et al. 2020

J Biochem & Molecular Tox

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Rotenone is a widely used organic pesticide; its serious side effect for off-target species is neurotoxicity. The primary mechanism of rotenone toxicity is inhibition of the mitochondrial complex I. Oxidative stress, apoptosis, and reduction of autophagy are key outcomes of the inhibition of complex I. Numerous in vitro and in vivo studies have shown antioxidant, anti-apoptotic, and autophagy enhancement of a variety of natural compounds (NCs). In this manuscript, we reviewed several NCs, which have protective effects against rotenone-induced neurotoxicity.

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“…However, administration of auraptene for 28 days showed some differences in the hematological and biochemical parameters of the treated and untreated groups, but all differences were within normal reference ranges. Histopathological investigation showed no toxic effects suggesting that suggested that auraptene is safe …”

Section: Introductionmentioning

confidence: 89%

“…Histopathological investigation showed no toxic effects suggesting that suggested that auraptene is safe. 22…”

Section: Structural Description Bioavailability and Safety Of Aurmentioning

confidence: 99%

A review of the pharmacological and therapeutic effects of auraptene

et al. 2019

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There is a growing awareness in herbal medications as they are usually safe and devoid of significant adverse effects. Auraptene is a natural bioactive monoterpene coumarin ether and is consumed all over the world. There is growing evidence of the therapeutic benefits of auraptene. Auraptene, also known as auraptene and 7‐geranyloxycoumarin, is a bioactive monoterpene coumarin from Rutaceae family, which is isolated from Citrus aurantium (Seville orange) and Aegle marmelos (bael fruit). Auraptene is a highly pleiotropic molecule, which can modulate intracellular signaling pathways that control inflammation, cell growth, and apoptosis. It has a potential therapeutic role in the prevention and treatment of various diseases due to its anti‐inflammatory and antioxidant activities as well as its excellent safety profile. In the present article, various pharmacological and therapeutic effects of auraptene were reviewed. Different online databases using keywords such as auraptene, therapeutic effects and pharmacological effects were searched until the end of September 2018, for this purpose. Auraptene has been suggested to be effective in the treatment of a broad range of disorders including inflammatory disorders, dysentery, wounds, scars, keloids, and pain. In addition, different studies have demonstrated that auraptene possesses numerous pharmacological properties including anti‐inflammatory, anti‐oxidative, anti‐diabetic, anti‐hypertensive and anti‐cancer as well as neuroprotective effects. The present review provides a detailed survey of scientific researches regarding pharmacological properties and therapeutic effects of auraptene.

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Safety evaluation of auraptene in rats in acute and subacute toxicity studies

Cited by 28 publications

References 24 publications

Aloe extract inhibits porcine epidemic diarrhea virus in vitro and in vivo

Aloe extract inhibits porcine epidemic diarrhea virus in vitro and in vivo

The protective effect of natural compounds against rotenone‐induced neurotoxicity

A review of the pharmacological and therapeutic effects of auraptene

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