Safety Evaluation of Dietary Aluminum

Soni, Madhusudan G.; White, Susan; Flamm, W.G.; Burdock, George A.

doi:10.1006/rtph.2000.1441

Cited by 220 publications

(140 citation statements)

References 66 publications

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“…The risk estimates showed that there were no significant risks involved in black tea intake as the maximum HQ value was less than one-tenth of the demarcation value. Researchers have concluded that neither dietary intake [34] nor intake from alum treated drinking water [35] is likely to contribute to Alzheimer's disease in contrast to the link found in an epidemiological study [8]. In this study, average, standard deviation, and maximum individual daily intake values were calculated as 1.4, 1.1, and 5.1 mg/day, respectively.…”

Section: Trace Metalsmentioning

confidence: 72%

“…In this study, average, standard deviation, and maximum individual daily intake values were calculated as 1.4, 1.1, and 5.1 mg/day, respectively. Taking 25 mg/day [34] as daily adult intake of Al from diet, tea would correspond to 6 and 20% at the mean and maximum levels, respectively. Stauber et al [35] estimated that contribution of tea to the total Al intake was 53% which was comparable to 41% for food in a total dietary intake of 3.2 mg/day.…”

Section: Trace Metalsmentioning

confidence: 99%

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An exposure and risk assessment for fluoride and trace metals in black tea

Sofuoğlu

Kavcar

2008

Journal of Hazardous Materials

102

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Exposure and associated health risks for fluoride and trace metals in black tea were estimated. Fifty participants were randomly recruited to supply samples from the tea that they drink, and self-administer a questionnaire that inquired about personal characteristics and daily tea intake. Analyzed trace metals included aluminum, arsenic, barium, cadmium, cobalt, chromium, copper, manganese, nickel, strontium, and zinc. Fluoride and four metals (Al, Cr, Mn, Ni) were detected in all samples while barium was detected only in one sample. The remaining metals were detected in >60% of the samples. Fluoride and aluminum levels in instant tea bag samples were greater than in loose tea samples (p < 0.05) while the differences in elemental concentrations of loose and pot bag tea samples were not significant. Median and 90th percentile daily tea intake rates were estimated as 0.35 and 1.1 l/day, respectively. Neither fluoride nor aluminum levels in black tea were found to associate with considerable risks of fluorosis and Alzheimer's disease, respectively. However, carcinogenic risk levels for arsenic were high; R > 1.0 × 10 −6 even at the median level. According to sensitivity analysis, daily tea intake was the most influencing variable to the risk except for arsenic for which the concentration distribution was of more importance.

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Section: Trace Metalsmentioning

confidence: 72%

Section: Trace Metalsmentioning

confidence: 99%

An exposure and risk assessment for fluoride and trace metals in black tea

Sofuoğlu

Kavcar

2008

Journal of Hazardous Materials

102

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“…24 Diyaliz ensefalopatisi ilk olarak 1972 yılında Alfrey ve ark.nın yetişkin-lerde tanımladığı ve uzun süreli hemodiyalizin oluşturduğu subakut, ilerleyici ve ölümcül bir komplikasyondur. 2,11,23,25 Böbrekler vücuda alınan Al itrahında en önemli organlardır ve absorbe edilen Al böbreklerden hızla elimine edilir. Böbrek hastalarında Al idrarla atılamaz ve beyin dâhil birçok dokuda birikir.…”

Section: Di̇yali̇z Ensefalopati̇si̇/demansiunclassified

Aluminum Toxicity and its Role in Neurodegenerative Diseases: Review

Sipahi¹,

Palabıyık²,

Balci³

et al. 2015

Turkiye Klinikleri J Neur

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6Alüminyum Toksisitesi ve Nörodejeneratif Hastalıklardaki Rolü Ö ÖZ ZE ET T Günlük yaşamımızda çok yaygın kullanılan alüminyum (Al), oksijen ve silikondan sonra yeryüzünde en fazla bulunan üçüncü elementtir. Endüstride paketleme, inşaat, elektrik aletleri ve içecek kutuları gibi birçok farklı ürünün yapımında kullanılan Al bileşikleri gıda katkı maddesi olarak da kullanılmaktadır. Türkiye'de de Gıda, Tarım ve Hayvancılık Bakanlığı tarafından "Türk Gıda Kodeksi Gıda Katkı Maddeleri Yönetmeliği" ekinde gıda katkı maddesi olarak kullanımına izin verilen miktarlar belirtilmiştir. Al gıdalara özellikle ilave edildiği durumlar dışında, kontaminasyon olarak da bulunmaktadır. Ayrıca gıdaların paketlenmesinde Al folyo kullanılması, gıdaların yüksek ısıda Al folyoda pişirilmesi de gıdaların Al içeriğini arttırmaktadır. Ancak gıda zincirindeki Al miktarı, antiasitler ve analjezikler gibi ilaçlarda kullanılan miktarıyla kıyaslandığında oldukça azdır. Al toksisitesi çoğunlukla kronik renal hasarı olan hastalarda veya iş yerinde Al'a maruz kalanlarda gö-rülmektedir. Akciğer, kemik ve santral sinir sistemi ana hedef organlardır. Alzheimer hastalığı, Parkinson hastalığı, Huntington hastalığı, Amyotrofik lateral skleroz, spinal muskuler atrofi gibi dünyada milyonlarca insanı etkileyen ve henüz kesin bir çözüm bulunamayan nörodejeneratif hastalıklarda beyin nöronlarının oksidatif strese oldukça duyarlı olduğu ve bunun Al toksisitesiyle indüklenebi-leceği düşünülmektedir. Deney hayvanlarında yapılan çalışmalar Al'un nörotoksik olduğunu, kanbeyin bariyerinin geçirgenliğini arttırdığını ve beyinde pek çok önemli enzimi inhibe ettiğini göstermiştir. Demansın belirgin olarak gözlenmediği diyaliz hastalarında da kan Al konsantrasyonları oldukça yüksek bulunmuştur. Ayrıca Al başta olmak üzere bazı toksik metaller düzeylerinde otistik çocuklarda sağlıklı çocuklara göre artış gözlenmiştir. Bu derlemenin amacı, yaygın kullanım alanına sahip Al'un nörodejeneratif hastalıklardaki rolünü değerlendirmektir.

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“…Patients for Alzheimer's disease, Parkinson disease and dialysis encephalopathy have high Aluminum concentrations in their brain tissues ( Soni et al, 2001;Tabrizi, 2007). Aluminum crosses the blood brain barrier (BBB) and accumulates in brain.…”

Section: Introductionmentioning

confidence: 99%

“…Aluminum crosses the blood brain barrier (BBB) and accumulates in brain. It is also accumulating in bones and liver, therefore, it's significantly damaging to patients with bone disease or renal dialysis, especially toxic to the elderly peoples and patients of kidney failure (Ranau et al, 2001;Soni et al, 2001). According to the neurological, mental disorders, development and substance (NMDS) there is a rise in neurological and mental disorders in the world and this rise is mainly due to the increase in the number of individuals reaching the age that is most susceptible to many of above mentioned disorders i.e old age (Murray et al, 2013;Spencer, 2013).…”

Section: Introductionmentioning

confidence: 99%

Aluminum Intoxication through Leaching in Food Preparation

Jabeen

Ali

Khan

et al. 2016

Alexandria Science Exchange Journal: An International Quarterly

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This study has been conducted to identify the correlation between food and aluminum intoxication through leaching. The ingestion is the main route of Aluminum exposure to the human body. Hence it is necessary to identify the aluminum levels in human body leached out from aluminum wares and aluminum foil. Pieces of chicken and red meat were baked with different types of solutions containing tomato juice, fresh yoghurt, salt and vinegar in different combinations, they were wrapped in aluminum foil in different combinations, marinated in aluminum pan and were tested for the pH and weight of pieces and foil. The result showed that citric acid with combination of lactic acid becomes the source for elevated level of aluminum in food items especially in raw beef. Citric acid with combination of tomato juice had highest accumulation rate than other solutions i.e 292.25mg/Kg in beef, while chicken leaching rate was 209.52mg/kg by the combination of yogurt and lemon juice. The fact still remains that once aluminum exceeds the acceptable limit from daily ingestion of food cooked in these pots, coupled with other sources from the environment. This environmental factor may contribute in increase of neurodegenerative diseases. The aim of this research study is to detect leaching out of aluminum levels from aluminum foil in different food solutions as it is becoming a common practice.

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Safety Evaluation of Dietary Aluminum

Cited by 220 publications

References 66 publications

An exposure and risk assessment for fluoride and trace metals in black tea

An exposure and risk assessment for fluoride and trace metals in black tea

Aluminum Toxicity and its Role in Neurodegenerative Diseases: Review

Aluminum Intoxication through Leaching in Food Preparation

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