Safety evaluation of kaempferol glycosides-rich standardized roasted goji berry leaf extract

Lee, Hyun Jeong; Lee, Somin; Ryu, Hyeon Yeol; Shim, Soon‐Mi

doi:10.1016/j.yrtph.2023.105382

Cited by 3 publications

(1 citation statement)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Kaempferol was bio-transformed by Phase I enzyme into quercetin [ 48 ], providing insight into the reason why kaempferol requires the S9 extract to act as a mutagen. Intriguingly, kaempferol or quercetin-rich nutraceuticals such as kaempferol glycoside-rich roasted goji berry leaf extract, kaempferol aglycone-rich horseradish leaf extract, and dihydroquercetin-rich extract were not found to be mutagenic when investigated in animal models (in vivo) [ 49 , 50 , 51 ]. This result was confirmed by data from Takanashi et al who showed that administration of kaempferol or quercetin in rats for 540 days did not significantly induce tumors compared with the control [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

Enhancing Therapeutic Efficacy of Donepezil, an Alzheimer’s Disease Drug, by Diplazium esculentum (Retz.) Sw. and Its Phytochemicals

Inthachat,

Chantong,

Pitchakarn

et al. 2024

Pharmaceuticals

View full text Add to dashboard Cite

Alzheimer’s disease (AD) is the most common type of dementia and a significant concern to global public health due to the prevalence of aging populations. Donepezil is one of only a few medications approved for use as an anti-AD agent but all have adverse side effects. Reducing the dosage of AD drugs with plant extracts (phytotherapy) while maintaining efficacy is one strategy to minimize adverse side effects. We previously reported the anti-AD properties of an edible fern, Diplazium esculentum (Retz.) Sw. (DE), which inhibited key enzymes involved in AD pathogenesis including acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and β-secretase 1 (BACE-1). This study aimed to determine whether DE exhibited a synergistic effect with donepezil. The enzyme inhibitory assay showed that DE extract and its bioactive compounds, kaempferol, and quercetin, slightly impeded AChE inhibition with donepezil, while DE extract and quercetin showed synergistic or additive effects with donepezil against BChE and BACE-1, respectively. DE extract combined with donepezil also improved eye phenotypes in a Drosophila model of AD by preventing ommatidia atrophia and bristle breakages. Furthermore, the DE extract exhibited no genotoxic activities, as determined by the Ames test. Our data revealed that DE extract showed promise when combined with donepezil during AD treatment by targeting BChE and BACE-1.

show abstract