Safety of EEG–fMRI recordings in newborn infants at 3T: A study using a baby-size phantom

Vanhatalo, Sampsa; Al-Najjar, Aiman; Nguyen, Vinh T.; Colditz, Paul B.; Fransson, Peter

doi:10.1016/j.clinph.2013.09.041

Cited by 12 publications

(8 citation statements)

References 13 publications

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“…However, this requires simultaneous EEG data collection during scanning. While the technology and procedures for collecting these data are available, combined fMRI-EEG acquisitions have only recently begun in infants (Arichi et al, 2017;Vanhatalo, Alnajjar, Nguyen, Colditz, & Fransson, 2014).…”

Section: Subject Statementioning

confidence: 99%

Neonatal brain injury and aberrant connectivity

et al. 2019

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Brain injury sustained during the neonatal period may disrupt development of critical structural and functional connectivity networks leading to subsequent neurodevelopmental impairment in affected children. These networks can be characterized using structural (via diffusion MRI) and functional (via resting state-functional MRI) neuroimaging techniques. Advances in neuroimaging have led to expanded application of these approaches to study term- and prematurely-born infants, providing improved understanding of cerebral development and the deleterious effects of early brain injury. Across both modalities, neuroimaging data are conducive to analyses ranging from characterization of individual white matter tracts and/or resting state networks through advanced 'connectome-style' approaches capable of identifying highly connected network hubs and investigating metrics of network topology such as modularity and small-worldness. We begin this review by summarizing the literature detailing structural and functional connectivity findings in healthy term and preterm infants without brain injury during the postnatal period, including discussion of early connectome development. We then detail common forms of brain injury in term- and prematurely-born infants. In this context, we next review the emerging body of literature detailing studies employing diffusion MRI, resting state-functional MRI and other complementary neuroimaging modalities to characterize structural and functional connectivity development in infants with brain injury. We conclude by reviewing technical challenges associated with neonatal neuroimaging, highlighting those most relevant to studying infants with brain injury and emphasizing the need for further targeted study in this high-risk population.

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Section: Subject Statementioning

confidence: 99%

Neonatal brain injury and aberrant connectivity

et al. 2019

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“…79,113 Finally, methodological advances increasingly employed in adults, such as use of electroencephalography (EEG) to define subject state during acquisition, are not typically performed in this age group. As these approaches are extrapolated to neonatal populations, 114 they may provide critical information regarding key variables such as the effects of state change on rs-fMRI results. 115 The potential for artifactual discrepancies introduced into measured results by these differences in standard procedures must be considered when comparing and interpreting rs-fMRI results across investigations.…”

Section: Future Directionsmentioning

confidence: 99%

Use of resting-state functional MRI to study brain development and injury in neonates

Smyser

Neil

2015

Seminars in Perinatology

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Advances in methodology have led to expanded application of resting state functional MRI (rs-fMRI) to the study of term and prematurely-born infants during the first years of life, providing fresh insight into the earliest forms of functional cerebral development. In this review, we detail our evolving understanding of the use of rs-fMRI for studying neonates. We initially focus on the biological processes of cortical development related to resting state network development. We then review technical issues principally affecting neonatal investigations, including the effects of subject motion during acquisition and image distortions related to magnetic susceptibility effects. We next summarize the literature in which rs-fMRI is used to study normal brain development during the early postnatal period, the effects of prematurity and the effects of cerebral injury. Finally, we review potential future directions for the field, such as the use of complementary imaging modalities and advanced analysis techniques.

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“…Precise studies on neurovascular coupling are based on concomitant measurements of brain hemodynamics and brain function (electrical activity of the brain). This can be done by combining EEG measurements with fMRI measurements (Mullinger and Bowtell, 2011), with fNIRS measurements (Shin et al, 2018) or with positron emission tomography measurements (Juhász et al, 2000), although such studies are challenging from a technical point of view due to for example electrode heating (Vanhatalo et al, 2014) and the presence of numerous artifacts (Galderisi et al, 2016; Abrue et al, 2018). Therefore, such studies are very scarce, especially in (preterm) neonates.…”

Section: Spatiotemporal Studiesmentioning

confidence: 99%

Measurement of Neurovascular Coupling in Neonates

et al. 2019

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Neurovascular coupling refers to the mechanism that links the transient neural activity to the subsequent change in cerebral blood flow, which is regulated by both chemical signals and mechanical effects. Recent studies suggest that neurovascular coupling in neonates and preterm born infants is different compared to adults. The hemodynamic response after a stimulus is later and less pronounced and the stimulus might even result in a negative (hypoxic) signal. In addition, studies both in animals and neonates confirm the presence of a short hypoxic period after a stimulus in preterm infants. In clinical practice, different methodologies exist to study neurovascular coupling. The combination of functional magnetic resonance imaging or functional near-infrared spectroscopy (brain hemodynamics) with EEG (brain function) is most commonly used in neonates. Especially near-infrared spectroscopy is of interest, since it is a non-invasive method that can be integrated easily in clinical care and is able to provide results concerning longer periods of time. Therefore, near-infrared spectroscopy can be used to develop a continuous non-invasive measurement system, that could be used to study neonates in different clinical settings, or neonates with different pathologies. The main challenge for the development of a continuous marker for neurovascular coupling is how the coupling between the signals can be described. In practice, a wide range of signal interaction measures exist. Moreover, biomedical signals often operate on different time scales. In a more general setting, other variables also have to be taken into account, such as oxygen saturation, carbon dioxide and blood pressure in order to describe neurovascular coupling in a concise manner. Recently, new mathematical techniques were developed to give an answer to these questions. This review discusses these recent developments.

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Safety of EEG–fMRI recordings in newborn infants at 3T: A study using a baby-size phantom

Cited by 12 publications

References 13 publications

Neonatal brain injury and aberrant connectivity

Neonatal brain injury and aberrant connectivity

Use of resting-state functional MRI to study brain development and injury in neonates

Measurement of Neurovascular Coupling in Neonates

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