Safety of Lactobacillus Reuteri DSM 17938 in Healthy Children 2–5 Years of Age

Kosek, Margaret; Peñataro-Yori, Pablo; Olórtegui, Maribel Paredes; Lefante, John J.; Ramal-Asayag, Cesar; Zamora-Babilonia, Marcelo; Sánchez, Graciela Meza; Oberhelman, Richard A.

doi:10.1097/inf.0000000000002267

Cited by 4 publications

(2 citation statements)

References 9 publications

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“…L. reuteri DSM 17938 isolated from human breast milk has been characterised and administered to infants with positive outcomes reported. Kosek et al reported no safety concerns when administered to two to five year old infants [275]. Studies have concluded it is effective and have recommended its use for infants with colic [276,277].…”

Section: Probiotic Bacteria In Breast Milkmentioning

confidence: 99%

Breast Milk, a Source of Beneficial Microbes and Associated Benefits for Infant Health

et al. 2020

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Human breast milk is considered the optimum feeding regime for newborn infants due to its ability to provide complete nutrition and many bioactive health factors. Breast feeding is associated with improved infant health and immune development, less incidences of gastrointestinal disease and lower mortality rates than formula fed infants. As well as providing fundamental nutrients to the growing infant, breast milk is a source of commensal bacteria which further enhance infant health by preventing pathogen adhesion and promoting gut colonisation of beneficial microbes. While breast milk was initially considered a sterile fluid and microbes isolated were considered contaminants, it is now widely accepted that breast milk is home to its own unique microbiome. The origins of bacteria in breast milk have been subject to much debate, however, the possibility of an entero-mammary pathway allowing for transfer of microbes from maternal gut to the mammary gland is one potential pathway. Human milk derived strains can be regarded as potential probiotics; therefore, many studies have focused on isolating strains from milk for subsequent use in infant health and nutrition markets. This review aims to discuss mammary gland development in preparation for lactation as well as explore the microbial composition and origins of the human milk microbiota with a focus on probiotic development.

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Section: Probiotic Bacteria In Breast Milkmentioning

confidence: 99%

Breast Milk, a Source of Beneficial Microbes and Associated Benefits for Infant Health

et al. 2020

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“…They include the induction of bacterial translocation, bacteremia, sepsis, bacterial dysbiosis and the conferral of bacterial resistance genes, further complicated by the development of systemic health problems induced by these conditions (30). Cumulative evidence from the literature nevertheless, proves an overall excellent safety record for the long-term consumption of probiotics by healthy adults and children (31)(32)(33). There are however various case reports of bacteremia, fungemia or bacterial dysbiosis or other adverse events.…”

Section: Safety Aspects Of Probiotics Consumptionmentioning

confidence: 99%

Probiotics in the Management of Gingivitis and Periodontitis. A Review

Schlagenhauf

Jockel‐Schneider

2021

Front. Dent. Med

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In the management of intestinal health problems, the targeted use of probiotic microorganisms is a common therapeutic measure with a long-standing tradition. In clinical dentistry however, probiotics-based therapy is still a rather new and developing field, whose usefulness for the control of gingivitis and periodontitis has been questioned by recent meta-analyses and systematic reviews. The purpose of the subsequent descriptive review is to provide an introduction to the concept of probiotic microorganisms and their multifaceted health-promoting interactions with the human host and microbial competitors, followed by a detailed comparison of the results of available controlled clinical trials assessing the use of probiotics in the control of gingival and periodontal inflammations. It aims at contributing to a deeper understanding of the unique capabilities of probiotics to resolve chronic plaque-induced inflammation even in the absence of mechanical plaque control and will discuss how possible misconceptions about the rationale for using probiotics may have led to the present controversies about their usefulness as a therapeutic option.

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