Safety of large-volume leukapheresis for collection of peripheral blood progenitor cells

Reik, Rita A.; Noto, Thomas A.; Fernandez, Hugo F.

doi:10.1002/(sici)1098-1101(1997)12:1<10::aid-jca3>3.0.co;2-d

Cited by 42 publications

(38 citation statements)

References 13 publications

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“…In addition to more optimal timing using our predictive model, other means to reduce leukapheresis sessions and improve leukapheresis yield that can be explored include large volume leukapheresis, which has been shown to reduce leukapheresis sessions to one or two, with processing of more than 15 L of blood [18,19]. The phenomenon of recruitment of progenitor cells might come into play during the more prolonged large volume leukapheresis [20].…”

Section: Discussionsupporting

confidence: 84%

Peripheral blood progenitor cell mobilization in three groups of subjects: A comparison of leukapheresis yield and timing

et al. 2000

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Section: Discussionsupporting

confidence: 84%

Peripheral blood progenitor cell mobilization in three groups of subjects: A comparison of leukapheresis yield and timing

et al. 2000

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“…Despite the large catheter size, these results are similar to published reports in hematopoietic stem cell transplant patients with central venous catheters used for pheresis, transplant, or both (Table 4). [38][39][40]42,[43][44][45][46][47][48][49][50][51][52][53][54][55][56] For patients treated using conventional chemotherapy regimens in which catheter duration extended from 1 to 1715 days, bacteremias ranged from 5 to 22%. [43][44][45][46][47][48] For six series disseminated infection experiences during pheresis (with or without hematopoietic stem cell transplantation) ranged from 2 to 9%.…”

Section: Dicussionmentioning

confidence: 99%

“…[43][44][45][46][47][48] For six series disseminated infection experiences during pheresis (with or without hematopoietic stem cell transplantation) ranged from 2 to 9%. [38][39][40][49][50][51] Many of the reports for the above two situations, however, failed to provide essential details such as in situ duration of catheters and number of local and blood-borne infections. Finally, for six large reports in which central venous catheters were used for 1-533 days during transplantation, bloodstream infections ranged from 4 to 39%.…”

Section: Dicussionmentioning

confidence: 99%

Multi-purpose silastic dual-lumen central venous catheters for both collection and transplantation of hematopoietic progenitor cells

Lazarus

Trehan

Miller

et al. 2000

Bone Marrow Transplant

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Summary:Autologous peripheral blood progenitor cell (PBPC) transplantation frequently requires sequential placement and use of two separate central venous catheters: (1) a short-term, large-bore, stiff device inserted for leukapheresis, and after removal of that device, (2) a longterm, multi-lumen, flexible, Silastic catheter for administration of high-dose chemotherapy, re-infusion of hematopoietic cells, and intensive supportive care. We reviewed our recent experience with two dual-lumen, large-bore, Silastic multi-purpose ('hybrid') catheters, each of which can be used as a single device for both leukapheresis and long-term supportive care throughout the transplant process. Quinton-Raaf PermCath and Bard-Hickman hemodialysis/apheresis dual-lumen catheters were used as the sole venous access device in 112 consecutive patients who underwent autologous PBPC collection and transplantation. The catheter exit site was monitored three times a week, and lumen patency was assessed using clinical and radiologic techniques. Catheters were removed prematurely for persistent thrombus, positive blood cultures despite appropriate antibiotics, or mechanical dysfunction. There were no intra-operative or immediate post-operative complications relating to insertion. Thirty-two patients experienced catheter occlusion necessitating urokinase instillation. Persistent occlusive problems were noted in 16 patients, and in 10 patients the catheter had to be removed. Two exit site infections and 17 bacteremias occurred. Catheters had to be removed for persistent infection in two subjects and for mechanical problems in five others. Cost analysis comparing the hybrid catheters alone vs conventional devices revealed a charge of $4230 in patients with hybrid catheters vs $7530 in those requiring a temporary non-Silastic dialysis catheter in addition to a flexible, long-term Silastic catheter. Hybrid, Silastic, dual-lumen, large-bore central venous catheters are safe, cost-effective and convenient multi-purpose venous access devices that may be used in the setting of autologous PBPC collection and transplantation.

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“…This could not completely be circumvented by individually tuned separation techniques and software improvements [9][10][11]. Adverse effects during the apheresis procedure are frequently observed and are caused by a electrolyte shifting, in particular hypocalcaemia due to the use of citrate for anticoagulation of whole blood [12,13].…”

Section: Introductionmentioning

confidence: 99%

Clinically relevant hypokalaemia, hypocalcaemia, and loss of hemoglobin and platelets during stem cell apheresis

Schlenke¹,

Frohn²,

Steinhardt³

et al. 2000

J. Clin. Apheresis

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Safety of large-volume leukapheresis for collection of peripheral blood progenitor cells

Cited by 42 publications

References 13 publications

Peripheral blood progenitor cell mobilization in three groups of subjects: A comparison of leukapheresis yield and timing

Peripheral blood progenitor cell mobilization in three groups of subjects: A comparison of leukapheresis yield and timing

Multi-purpose silastic dual-lumen central venous catheters for both collection and transplantation of hematopoietic progenitor cells

Clinically relevant hypokalaemia, hypocalcaemia, and loss of hemoglobin and platelets during stem cell apheresis

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