Safety of liposomal cytarabine CNS prophylaxis in children, adolescent and young adult hematopoietic stem cell transplant recipients with acute leukemia and non-Hodgkin lymphoma

Hochberg, Jessica; Harrison, Lauren; Morris, Erin; Militano, Olga; Brand, Phyllis; Fabricatore, Sandra; Wolownik, K.; Cairo, Mitchell S.

doi:10.1038/bmt.2016.100

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Cited by 4 publications

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“…Several large, multicenter studies have evaluated this approach and have shown a significant decrease in CNS disease. 46,47 However, the optimal dose, infusion rate, number of cycles required, and need for concomitant IT MTX are unknown. In addition, high-dose MTX requires inpatient administration, clinical expertise, and rapid access to serum blood levels (to check MTX levels) to prevent toxicity.…”

Section: Preventionmentioning

confidence: 99%

Diagnosis and Management of Leukemic and Lymphomatous Meningitis

2017

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Appropriate selection of patients at high risk for leukemic and lymphomatous meningitis is important so that preventive strategies can decrease the incidence of this complication of leukemia and lymphoma. Use of chemotherapy agents that cross the blood-brain barrier and the adoption of high-dose chemotherapy with autologous hematopoietic stem cell transplantation have increased the proportion of patients whose primary disease is cured.

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Section: Preventionmentioning

confidence: 99%