Safety of measles, mumps, and rubella vaccine in adolescents and adults in the vaccine safety Datalink

Hanson, Kayla E.; Marin, Mona; Daley, Matthew F.; Groom, Holly; Jackson, Lisa A.; Sy, Lina S; Klein, Nicola P.; DeSilva, Malini B.; Panagiotakopoulos, Lakshmi; Weintraub, Eric; Belongia, Edward A; McLean, Huong Q.

doi:10.1016/j.jvacx.2023.100268

Cited by 4 publications

(2 citation statements)

References 26 publications

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“…Additionally, in safety trials of MMR vaccine in humans, rare serious outcomes have been observed in adults [62]. Regarding the safety of the MMR vaccine used in our study, European Medicine Agency has conducted various safety trials of this vaccine in adults and children no younger than 9 months and found no toxicity [63].…”

Section: Discussionmentioning

confidence: 99%

Anticancer Activity of Measles–Mumps–Rubella MMR Vaccine Viruses against Glioblastoma

Khalid,

Coco,

Ullah

et al. 2023

Cancers

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Background: Oncolytic viruses (OVs) have been utilized since 1990s for targeted cancer treatment. Our study examined the Measles–Mumps–Rubella (MMR) vaccine’s cancer-killing potency against Glioblastoma (GBM), a therapy-resistant, aggressive cancer type. Methodology: We used GBM cell lines, primary GBM cells, and normal mice microglial cells, to assess the MMR vaccine’s efficacy through cell viability, cell cycle analysis, intracellular viral load via RT-PCR, and Transmission Electron Microscopy (TEM). Results: After 72 h of MMR treatment, GBM cell lines and primary GBM cells exhibited significant viability reduction compared to untreated cells. Conversely, normal microglial cells showed only minor changes in viability and morphology. Intracellular viral load tests indicated GBM cells’ increased sensitivity to MMR viruses compared to normal cells. The cell cycle study also revealed measles and mumps viruses’ crucial role in cytopathic effects, with the rubella virus causing cell cycle arrest. Conclusion: Herein the reported results demonstrate the anti-cancer activity of the MMR vaccine against GBM cells. Accordingly, the MMR vaccine warrants further study as a potential new tool for GBM therapy and relapse prevention. Therapeutic potential of the MMR vaccine has been found to be promising in earlier studies as well.

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Section: Discussionmentioning

confidence: 99%

Anticancer Activity of Measles–Mumps–Rubella MMR Vaccine Viruses against Glioblastoma

Khalid,

Coco,

Ullah

et al. 2023

Cancers

View full text Add to dashboard Cite

show abstract

“…However, adolescents that are also included in the VH group need attention.. Because adolescents are more likely than adults to acquire information and adjust their vaccination behavior, early intervention measures for VH, such as in the case of the COVID-19 vaccine, are expected to be more effective [7] . Since World Health Organization (WHO) and many research gives some consideration to vaccinating adolescents [12] , [13] , [14] , [15] , [16] , this literature review aims to provide an overview of the situation of VH in adolescents towards COVID-19 vaccination. Furthermore, it is expected to answer pertinent questions concerning adolescent perspectives on the COVID-19 vaccination and the factors that influence them.…”

Section: Introductionmentioning

confidence: 99%

Vaccine hesitancy in adolescents regarding COVID-19 vaccination: A literature review

Dhamayanti,

Andriyani,

Moenardi

et al. 2024

Vaccine: X

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Relationship between vaccine hesitancy and vaccination behaviors: Systematic review and meta-analysis of observational studies

Yang,

Shi,

Liu

et al. 2024

Vaccine

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Safety of measles, mumps, and rubella vaccine in adolescents and adults in the vaccine safety Datalink

Cited by 4 publications

References 26 publications

Anticancer Activity of Measles–Mumps–Rubella MMR Vaccine Viruses against Glioblastoma

Anticancer Activity of Measles–Mumps–Rubella MMR Vaccine Viruses against Glioblastoma

Vaccine hesitancy in adolescents regarding COVID-19 vaccination: A literature review

Relationship between vaccine hesitancy and vaccination behaviors: Systematic review and meta-analysis of observational studies

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