Safety of the proposed extension of use of acesulfame K (E 950) in foods for special medical purposes in young children

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doi:10.2903/j.efsa.2016.4437

Cited by 3 publications

(3 citation statements)

References 2 publications

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“…A further seven studies were identified from authoritative sources [70,71,72,73,74,75,76]. These data examined exposure by various EU population groups to all seven sweeteners of interest.…”

Section: Methodology and Trends In Intakementioning

confidence: 99%

“…These data examined exposure by various EU population groups to all seven sweeteners of interest. Most of the scientific opinions published by the EFSA examined intake in response to requests for extension of use for specific sweeteners considering the total diet [73,74] or in foods for special medical purposes (FSMPs) [75,76]. Acesulfame-K and aspartame have been the most frequently evaluated sweeteners in Europe, with intakes estimated for both sweeteners in 16 different peer-reviewed publications and in one EFSA scientific opinion.…”

Section: Methodology and Trends In Intakementioning

confidence: 99%

“…There were some exceptions to this approach, such as the inclusion of summary statistics derived from the EFSA Comprehensive dataset or the FAIM tool [62,68,70,73,74,78] and annual estimated per capita beverage consumption data [54,55,59]. Two assessments by the EFSA considered specific consumption scenarios based on the proposed use of sucralose and acesulfame-K in FSMPs by young children [75,76]. …”

Section: Methodology and Trends In Intakementioning

confidence: 99%

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Low-/No-Calorie Sweeteners: A Review of Global Intakes

et al. 2018

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The current review examined published data on the intake of all major low-/no-calorie sweeteners—aspartame, acesulfame-K, saccharin, sucralose, cyclamate, thaumatin and steviol glycosides—globally over the last decade. The most detailed and complex exposure assessments were conducted in Europe, following a standardized approach. Japan and Korea similarly had up-to-date and regular intake data available. The data for other Asian countries, Latin America, Australia/New Zealand and global estimates, evaluated by the Joint FAO/WHO Expert Committee on Food Additives (JECFA), while available, were shown to be more limited in terms of design. Overall, the studies conducted since 2008 raised no concerns with respect to exceedance of individual sweetener acceptable daily intake (ADIs) among the general population globally. The data identified do not suggest a shift in exposure over time, with several studies indicating a reduction in intake. However, some data suggest there may have been an increase in the numbers of consumers of low-/no-calorie-sweetened products. Future research should consider a more standardized approach to allow the monitoring of potential changes in exposure based upon events such as sugar reduction recommendations, to ensure there is no shift in intake, particularly for high-risk individuals, including diabetics and children with specific dietary requirements, and to ensure risk management decisions are based on quality intake analyses.

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Section: Methodology and Trends In Intakementioning

confidence: 99%

Section: Methodology and Trends In Intakementioning

confidence: 99%

Section: Methodology and Trends In Intakementioning

confidence: 99%

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Low-/No-Calorie Sweeteners: A Review of Global Intakes

et al. 2018

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A Review of the Environmental Fate and Effects of Acesulfame‐Potassium

Belton¹,

Schaefer

Guiney³

2020

Integr Envir Assess & Manag

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The use of low and no calorie sweeteners (LNCSs) has increased substantially the past several decades. Their high solubility in water, low absorption to soils, and reliable analytical methods facilitate their detection in wastewater and surface waters. Low and no calorie sweeteners are widely used in food and beverage products around the world, have been approved as food additives, and are considered safe for human consumption by the United States Food and Drug Administration (USFDA) and other regulatory authorities. Concerns have been raised, however, regarding their growing presence and potential aquatic toxicity. Recent studies have provided new empirical environmental monitoring, environmental fate, and ecotoxicity on acesulfame potassium (ACE‐K). Acesulfame potassium is an important high‐production LNCS, widely detected in the environment and generally reported to be environmentally persistent. Acesulfame‐potassium was selected for this environmental fate and effects review to determine its comparative risk to aquatic organisms. The biodegradation of ACE‐K is predicted to be low, based on available quantitative structure–activity relationship (QSAR) models, and this has been confirmed by several investigations, mostly published prior to 2014. More recently, there appears to be an interesting paradigm shift with several reports of the enhanced ability of wastewater treatment plants to biodegrade ACE‐K. Some studies report that ACE‐K can be photodegraded into potentially toxic breakdown products, whereas other data indicate that this may not be the case. A robust set of acute and chronic ecotoxicity studies in fish, invertebrates, and freshwater plants provided critical data on ACE‐K's aquatic toxicity. Acesulfame‐potassium concentrations in wastewater and surface water are generally in the lower parts per billion (ppb) range, whereas concentrations in sludge and groundwater are much lower (parts per trillion [ppt]). This preliminary environmental risk assessment establishes that ACE‐K has high margins of safety (MOSs) and presents a negligible risk to the aquatic environment based on a collation of extensive ACE‐K environmental monitoring, conservative predicted environmental concentration (PEC) and predicted no‐effect concentration (PNEC) estimates, and prudent probabilistic exposure modeling. Integr Environ Assess Manag 2020;16:421–437. © 2020 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals, Inc. on behalf of Society of Environmental Toxicology & Chemistry (SETAC)

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Food Additives Associated with Gut Microbiota Alterations in Inflammatory Bowel Disease: Friends or Enemies?

et al. 2022

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During the 21st century, the incidence and prevalence of inflammatory bowel disease (IBD) is rising globally. Despite the pathogenesis of IBD remaining largely unclear, the interactions between environmental exposure, host genetics and immune response contribute to the occurrence and development of this disease. Growing evidence implicates that food additives might be closely related to IBD, but the involved molecular mechanisms are still poorly understood. Food additives may be categorized as distinct types in accordance with their function and property, including artificial sweeteners, preservatives, food colorant, emulsifiers, stabilizers, thickeners and so on. Various kinds of food additives play a role in modifying the interaction between gut microbiota and intestinal inflammation. Therefore, this review comprehensively synthesizes the current evidence on the interplay between different food additives and gut microbiome alterations, and further elucidates the potential mechanisms of food additives–associated microbiota changes involved in IBD.

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Safety of the proposed extension of use of acesulfame K (E 950) in foods for special medical purposes in young children

Cited by 3 publications

References 2 publications

Low-/No-Calorie Sweeteners: A Review of Global Intakes

Low-/No-Calorie Sweeteners: A Review of Global Intakes

A Review of the Environmental Fate and Effects of Acesulfame‐Potassium

Food Additives Associated with Gut Microbiota Alterations in Inflammatory Bowel Disease: Friends or Enemies?

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