Safety of Tranexamic Acid in Pediatric Cardiac Surgery: A Nationwide Database Study

Maeda, Takuma; Sasabuchi, Yusuke; Matsui, Hiroki; Ohnishi, Yoshihiko; Miyata, Shigeki; Yasunaga, Hideo

doi:10.1053/j.jvca.2016.10.001

Cited by 37 publications

(36 citation statements)

References 26 publications

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“…55 Another study that used propensity matching to compare trauma patients who did and did not receive TXA found that the TXA group had a higher rate of seizures, but the two groups had equivalent rates of thromboembolic complications and mortality. 56 Clinical trials are currently being developed to study the impact of TXA on pediatric TIC. Disorders of fibrinolysis exist on a spectrum, with a majority of trauma patients arriving to the hospital in a state of abnormal fibrinolysis.…”

Section: Tranexamic Acidmentioning

confidence: 99%

Trauma-Induced Coagulopathy in Children

Lucisano

Leeper

Gaines

2020

Semin Thromb Hemost

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Trauma-induced coagulopathy (TIC) is well documented in injured children. However, many important features of pediatric hemostasis are still in development in early childhood and may impact TIC. Certain pediatric subgroups are at a higher risk. Traumatic brain injury, which occurs with a higher rate in children, and physical child abuse are known risk factors for TIC that deserve special consideration. Resuscitation of a pediatric trauma patient follows many of the same goals as in the injured adult trauma, although some key aspects of pediatric resuscitation require ongoing investigation. Venous thromboembolism occurs with higher rates in certain high-risk groups of pediatric trauma patients, although overall it is considerably less frequent in children as compared with adults.

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Section: Tranexamic Acidmentioning

confidence: 99%

Trauma-Induced Coagulopathy in Children

Lucisano

Leeper

Gaines

2020

Semin Thromb Hemost

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“…25 In a recent military retrospective cohort study, Johnston and colleagues 26 reported that TXA was an independent risk factor for venous thromboembolism (odds ratio, 2.58; 95% CI, 1.20-5.56; p = 0.02), suggesting a reappraisal of its clinical use in combat casualties. These potential adverse effects also need to be considered for the prophylactic TXA use in pediatric 27 and adult 25 elective and emergency surgeries.…”

Section: It Is Only the Beginning: A Case For The Development Of New mentioning

confidence: 99%

Clinical relevance of a p value: Does tranexamic acid save lives after trauma or postpartum hemorrhage?

Dobson

Doma

Letson

2018

J Trauma Acute Care Surg

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“…A nationwide data base study in japan 2016, Maeda et al retrospective cohort study showed a significant increase in seizures risk with use of TA in pediatric patients who underwent cardiac surgery [99]. The use of high-dose TA in older patients in conjunction with cardiopulmonary bypass and open-chamber cardiac surgery [100][101][102][103] was associated with clinical seizures, which could be due to ischemic brain injury [104]. These seizures are more pronounced in those with perioperative renal disease [105].…”

Section: Seizures and Renal Complicationsmentioning

confidence: 99%

Tranexamic Acid and Major Spine Surgery: Trends and Controversies

Pisklakov¹,

Ibrahim²,

Huang³

2017

J Surg Anesth

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The beneficial role and efficacy of Tranexamic Acid in reducing perioperative blood loss and blood transfusion requirements in spine surgery is being established. Tranexamic Acid is an antifibrinolytic agent traditionally used to lessen perioperative blood loss. Tranexamic Acid can be administered orally, intramuscularly, intravenously or topically. Tranexamic Acid studies in spine surgery have limited patient enrolment. Most of the reported studies have mixed results and difficult to interpret. The efficacy of antifibrinolytic agents is evident in a wide variety of surgical procedures: liver transplantation, obstetrics and gynaecology, trauma and orthopaedic surgical procedures. The effect of Tranexamic Acid on the occurrence of thromboembolic events, strokes, myocardial ischemia, seizures and mortality has not been adequately assessed and remains uncertain. A number of possible complications reported. In this review, we analyze the efficacy and safety profile of perioperative Tranexamic Acid with the exclusion of cardiac surgery and a focus on major spinal surgery.

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Safety of Tranexamic Acid in Pediatric Cardiac Surgery: A Nationwide Database Study

Cited by 37 publications

References 26 publications

Trauma-Induced Coagulopathy in Children

Trauma-Induced Coagulopathy in Children

Clinical relevance of a p value: Does tranexamic acid save lives after trauma or postpartum hemorrhage?

Tranexamic Acid and Major Spine Surgery: Trends and Controversies

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