Safety of transtympanic application of probiotics in a chinchilla animal model

Nhan, Carol; Bezdjian, Aren; Saha, Shyamali; Prakash, Satya; Nguyen, Lily H. P.; Daniel, Sam J.

doi:10.1186/s40463-017-0242-y

Cited by 9 publications

(3 citation statements)

References 28 publications

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“…In this regard, in a study on patients with second and 3rd-degree burn wounds, Peral et al (2019) showed that dermal treatment with L. plantarum may reduce the bacterial count in the wounds [31] . Also, Carol Nhan et al (2017) indicated that L. plantarum could reduce the S. aureus and P. aeruginosa growth in the wounds [32] . Moreover, the use of lactic acid bacteria as probiotic may accelerate wound healing process and reduce infection by different mechanisms [29] .…”

Section: Discussionmentioning

confidence: 99%

Macroscopic and Microscopic Survey of the Comparative Effects of Lactobacillus plantarum 299v, Its Supernatant, and Imipenem on Infectious Burn Wound Healing in Rats

moghaddam

Shabestari

Heidari

et al. 2020

IEM

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Burn infections are one of the most common causes of mortality in the world. On the other hand, microbial resistance to antibiotics has caused concern in the medical community. Therefore, controlling burn infections is very important, and using alternative therapies instead of antibiotics could be a good solution to this problem. Materials & Methods: Lactobacillus plantarum 299v strains were used in the experiments. Fifty male Wistar rats were prepared, and burn was induced in animals. The burn wounds were inoculated with clinical strains of MDR Pseudomonas aeruginosa in all animals and then treated daily with an eucerin ointment containing different compositions, including NaCl, imipenem, probiotic cell pellet, probiotic supernatant, and probiotic cell pellet + probiotic supernatant. The wound healing process was evaluated in animals after 7 days of treatment. Comparisons between different groups were performed using One-way ANOVA and Turkey's post hoc tests. Findings: After 7 days of treatment, the mean wound size in the probiotic cell pellet group was significantly lower than in the control and imipenem groups. Also, the mean wound size in the probiotic supernatant group was significantly lower than in the imipenem group. Histological parameters related to skin repair in the probiotic cell pellet group was better than in the control and antibiotic groups. Also, inflammation in the probiotic cell pellet group was less than in the control and imipenem groups. Conclusion:The macroscopic results of this study supported the microscopic results and showed that the mean size of the burn wounds in the probiotic cell pellet group was less than in the control and imipenem groups after 7 days of treatment.

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Section: Discussionmentioning

confidence: 99%

Macroscopic and Microscopic Survey of the Comparative Effects of Lactobacillus plantarum 299v, Its Supernatant, and Imipenem on Infectious Burn Wound Healing in Rats

moghaddam

Shabestari

Heidari

et al. 2020

IEM

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“…As an alternative to antibiotics, research is being carried out on the possibility of using pharmaceutical preparations based on silver such as Silver Chloride Gel [2] and Argentum Quartz (R) [3], probiotics such as Lactobacillus plantarum [4], Curcumin oile [5] and new types of bandages, for example the Lawsonia Inermisgelatin-starch nano-fibrous bandage [6]. However, these methods are only for topical use and do not have a systemic effect, so they does not act upon the site of chronic infection (which often forms after the biofilm formation), and also does not affect the immune system.…”

Section: Introductionmentioning

confidence: 99%

Bovhyaluronidaze azoximer as an antimicrobial alternative in companion animals

Nazarova¹,

Semenov²,

Kozitcyna³

et al. 2021

BIO Web Conf.

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Antimicrobial resistance formation in various bacteria is a serious biosafety threat. In this regard, the important issue in medical and veterinary fields is not only the rational use of antibacterial drugs, but also the search for ways to significantly reduce the need for antibiotics. Three studies designed to research into these challenges are described. The results indicated that (1) the bacteriuria presences in 62.4 +/-4.1% of urine samples obtained from companion animals (the microflora count in urine samples is estimated from ’++’ to ’Entire Field-of-View’); (2) 16.3 +/-4.0% of samples from companion animals showed bacteria with low antibiotics sensitivity, and 8.1 +/-3.0% of samples contained bacteria resistant to 30 antibiotics included in the susceptibility test; (3) the Bovhyaluronidaze azoximer reduce antimicrobial therapy duration statistically significant (p=0.0089). The studies were conducted at the facilities of St. Petersburg State University of Veterinary Medicine and Bars veterinary clinic chain in St. Petersburg, Russia. A randomized clinical trial of Bovhyaluronidaze azoximer effect on course of disease and treatment duration of acute and chronic prostatitis and urocystitis, including complicated by urolithiasis, was conducted in 54 dogs. Animals were randomly assigned to intervention (n=34) and control (n=20) groups. Animals of both groups received the antimicrobial therapy. Interventional group patients additionally received Bovhyaluronidaze azoximer in the form of rectal suppositories. The antimicrobial therapy mean duration in intervention group animals took 14.88 +/-4.98 days, in control group animals — 18.65 +/-5.40 days. The study findings imply that bacteriuria is widely prevalent in companion animals and antimicrobial resistance is increasing issue in veterinary medicine. Bovhyaluronidaze azoximer contributes to microcirculation restore and increases the bioavailability of antibacterial drugs at the site of infection. This makes its relevant for use in the complex treatment for septic and inflammatory processes. This allows to reduce the antimicrobial course duration (and completely decline antibiotic therapy in some cases) and prevent the formation of chronic inflammation and infection sites.

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“…There is recent research in advanced treatment methods of inflammatory and purulent processes. The use of silver [2,3], probiotics [4], curcumin oil [5] preparations and new wound dressing [6] in the treatment of suppurative wounds is being investigated. However, this is a topical wound therapy.…”

Section: Introductionmentioning

confidence: 99%

The use of Bovhyaluronidaze azoximer preparation in the treatment of suppurative wounds in companion animals

et al. 2020

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Increasing the number of dogs and cats kept in urban households makes relevant research of new effective methods of treatment of companion animals. We conducted studies of the effect of Bovhyaluronidaze azoximer on the treatment duration of suppurative wounds. The study was carried out on 42 animals (24 cats and 18 dogs) with septic processes in two groups. The animals of the both groups were given conventional therapy; in animals of the experimental group the Bovhyaluronidaze azoximer preparation was additionally included as a part of a complex therapy. The effect of the use Bovhyaluronidaze azoximer preparation was evaluated by three indicators: the wound cleansing from purulonecrotic masses duration, the duration of existence of edema, the number of managements of wound. The median wound cleansing time in the experimental group improve on 2.29 days. The median duration of existence of edema in the experimental group was in less time on 1.57 days in comparison with the control group. The median number of required managements of wound is reduced by 5.00 manipulations in the experimental group in comparison with the control group. The results of our study show that Bovhyaluronidaze azoximer can be recommended for use in the therapy of suppurative wounds.

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Safety of transtympanic application of probiotics in a chinchilla animal model

Cited by 9 publications

References 28 publications

Macroscopic and Microscopic Survey of the Comparative Effects of Lactobacillus plantarum 299v, Its Supernatant, and Imipenem on Infectious Burn Wound Healing in Rats

Macroscopic and Microscopic Survey of the Comparative Effects of Lactobacillus plantarum 299v, Its Supernatant, and Imipenem on Infectious Burn Wound Healing in Rats

Bovhyaluronidaze azoximer as an antimicrobial alternative in companion animals

The use of Bovhyaluronidaze azoximer preparation in the treatment of suppurative wounds in companion animals

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